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Peptide Therapy

There are many potential benefits of peptide therapy in different medical fields. This Cureus article explores the expression of antimicrobial peptides and cytokines in the human omentum following abdominal surgery, with the aim of understanding how these peptides can aid in the prevention of postoperative infections. The article below focuses on the effects of Mechano-Growth Factor (MGF) peptide, which has been shown to have favorable impacts on muscle growth, wound healing, cartilage repair, and brain development in animal studies. MGF peptide has also been shown to activate muscle stem cells and enhance heart health, among other benefits.  There is a growing interest in peptide therapy as a potential solution to various medical problems, from muscle loss to postoperative infections. Sponsored Content Peptide Research: an Overview Mechano-Growth Factor (MGF) peptide is a splice variant of insulin-like growth factor [i] that has been suggested to have cardiological effects, favorably influencing muscle growth, wound healing, cartilage repair, and brain development in animal studies. MGF C-terminal has been speculated to enhance muscle healing after damage and hasten recovery. Moreover, data is suggesting it may help shield tissues from the mechanical stressors incurred during training and physical activity. Do you have a Ph.D. or MD and need to purchase MGF peptides for your research? You can find high-quality, affordable peptides online. What is the Mechano Growth Factor? In contrast to IGF1, the peptide known as Mechano growth factor (MGF) [ii] has a slightly modified sequence. Research suggests it may significantly impact growth and development. Animal studies purport that MGF peptide may promote tissue repair and development by activating muscle stem cells and increasing protein synthesis for tissue growth. Researchers are now exploring this peptide as a potential adjuvant for disorders that cause muscle loss and wasting in animals. Animal studies support that MGF peptide may promote tissue repair and development by activating muscle stem cells and increasing protein synthesis for tissue growth. Researchers are now exploring this peptide as a potential therapy for disorders that cause muscle loss and wasting in animals. MGF Peptide: Mechanism of Action According to research, IGF and muscle growth factor (MGF) seem to work together to cause hypertrophy and speed up the healing process after muscle injury. Muscle satellite cells, also known as stem cells, are activated with their help, per experimental study results. [v] Investigations purport the IGF-1Eb isoform, as it's more often known, may protect neurons, mitigate the atrophying effects of insulin, and speed up the healing of damaged muscle tissue in animals. Studies in rats have asserted the efficacy of this peptide. After muscular damage, high levels of MGF were found in the rats' muscles, which have been hypothesized to have promoted skeletal muscle cell development. Research on MGF for disorders that cause muscle wasting or tissue damage is limited, but early results are encouraging. MGF Peptide Properties According to the scientific community's findings, MGF peptides have a wide range of applications. In a nutshell, here's what it can do, according to animal studies: Encourage the growth of new muscle by stimulating stem cells Facilitate healing, repair, and cell division Facilitate the reduction of inflammation Maximize workouts Improve mental well-being and growth Enhance heart health Muscle Growth Factor's Effects Recent studies have shown that MGF (Mechanical growth factor) may stimulate satellite cells in the body, leading to increased hypertrophy, larger muscles, and even muscle regeneration. According to animal studies, MGF administered to mice for three weeks resulted in a 25% increase in muscle growth. Researchers think this peptide has the potential to double the health benefits of exercise and cure muscle-wasting disorders. An animal's basal metabolic rate and the pace at which it burns calories at rest benefit from muscle gain. Thus the animal may see more than simply an aesthetic advantage from exercising. Animal studies have demonstrated that increased lean body mass helps alleviate various diseases and health problems linked to obesity. Transplantation of myogenic precursor cells enhances dystrophin expression, which may explain why MGF therapy is effective in the context of some muscle-wasting illnesses like Duchenne muscular dystrophy (DMD). As a result, the negative consequences of these states are mitigated. Despite the treatment's encouraging name, post-transplant survival statistics are dismal. Animal studies suggest that C-terminal peptide may improve transplant outcomes by increasing the number of myogenic precursor cells that survive the procedure. MGF Peptide and Injuries Injuries, inflammatory diseases like arthritis, and overuse of joints may all lead to cartilage breakdown. Experts agree that poor blood flow and a lack of stem cells prevent cartilage from regenerating properly. Yet, research on MGF peptides in animals suggested that they might assist in overcoming many of the obstacles to cartilage regeneration. Research indicates that C-terminal [iii] MGF might help chondrocytes (cells that promote cartilage health and repair) endure exposure to noxious stimuli, including damage and physical stress. By increasing cell survival, MGF supplementation has been theorized to aid in protecting and repairing cartilage when mechanical stress is applied, as per studies. Rodent studies indicated that MGF peptide might stop disc degeneration by stopping cell apoptosis. [iv]  Cardiological Consequences Data from animal trials of acute myocardial infarction in sheep suggests that MGF peptide may prevent heart muscle damage caused by ischemia. Researchers also speculated that cardiomyocyte damage seemed reduced by 35% when MGF peptide was presented. MGF Peptide and the Brain In 2010, scientists asserted that MGF peptide was present in the brains of rats, suggesting the peptide's possible neuroprotective properties. Research in mice further indicates that MGF protein is expressed in the context of brain hypoxia and that it may protect neurons. Studies purport that MGF peptide may relieve the increasing muscular weakness seen in Lou Gehrig's disease (ALS) and slow down the underlying cause of the illness, the degeneration of motor neurons. Researchers have ascertained that mechano-growth factor peptides may protect neurons from disease progression more effectively than any other isoform. It has also been hypothesized to aid in recovering brain tissue damaged by ischemia. Scientists have high hopes that MGF peptide, with further study, may prove to be adjuvant and may save motor neurons from dying. References [i] Philippou A, Papageorgiou E, Bogdanis G, Halapas A, Sourla A, Maridaki M, Pissimissis N, Koutsilieris M. Expression of IGF-1 isoforms after exercise-induced muscle damage in humans: characterization of the MGF E peptide actions in vitro. In Vivo. 2009 Jul-Aug;23(4):567-75. [ii] Moriggl, R, V Gouilleux-Gruart, R Jähne, S Berchtold, C Gartmicen, X Liu, L Hennighausen, A Sotiropoulos, B Groner, and F Gouilleux. “Deletion of the Carboxyl-Terminal Transactivation Domain of MGF-Stat5 Results in Sustained DNA Binding and a Dominant Negative Phenotype.” Molecular and Cellular Biology 16, no. 10 (October 1996): 5691–5700. doi:10.1128/mcb.16.10.5691. [iii] Esposito, Simone, Koen Deventer, and Peter Van Eenoo. “Characterization and Identification of a C-Terminal Amidated Mechano Growth Factor (MGF) Analogue in Black Market Products.” Rapid Communications in Mass Spectrometry 26, no. 6 (February 10, 2012): 686–692. doi:10.1002/rcm.6144. [iv] Liu X, Zeng Z, Zhao L, Chen P, Xiao W. Impaired Skeletal Muscle Regeneration Induced by Macrophage Depletion Could Be Partly Ameliorated by MGF Injection. Front Physiol. 2019 May 17;10:601. [v] Mills P, Dominique JC, Lafrenière JF, Bouchentouf M, Tremblay JP. A synthetic mechano growth factor E Peptide enhances myogenic precursor cell transplantation success. Am J Transplant. 2007 Oct;7(10):2247-59. Editor's Note: This blog post was sponsored by Core Peptides LLC.

Apr 22, 2024

Reflecting on the Success of the Cureus India Medical Science & Publishing Symposium

The Cureus India Medical Science & Publishing Symposium 2024 was held on March 7th, 2024 at the Shangri-La Hotel in New Delhi. This landmark event represented a pivotal moment for Open Access healthcare research publishing. With over 100 healthcare CXOs and professionals from prestigious institutions such as AIIMS New Delhi, Max Healthcare, Medanta, Apollo Hospitals, APAR, Fortis, and Manipal Hospitals in attendance, the symposium was a melting pot of ideas, innovations, and insights aimed at advancing the healthcare ecosystem. The symposium included a keynote speech from Dr. B.N. Gangadhar, Chairman of the National Medical Commission (NMC). His address on the healthcare ecosystem underscored the symposium's central theme: leveraging Open Access to propel healthcare research into new frontiers. The discussions, panel interactions, and Q&A sessions were vibrant and insightful, focusing on the critical role of Open Access in disseminating research more effectively to a wider audience. A key highlight was the announcement of a significant partnership between Cureus and SRM University (Medical College). This collaboration underscores SRM University's commitment to excellence and innovation in medical research. This partnership fortifies the journal's mission to promote accessible and sustainable Open Access publishing. The symposium's success was mirrored in the keen interest shown by various institutes, sparking conversations about potential collaborations with Cureus. The event provided an excellent opportunity for medical researchers and clinicians to network. This enthusiasm shown was a testament to the event's impact, broadening the journal's reach within the healthcare community and opening up new avenues for growth and partnership in India. The event also received significant media coverage, with nearly 50 healthcare media houses highlighting the symposium in both online and offline formats. This exposure plays a crucial role in enhancing Cureus's visibility in the Indian healthcare ecosystem, showcasing the symposium's innovative discussions and the broader implications for healthcare research and publishing. Looking ahead, the insights and collaborations born from this symposium promise to shape the future of healthcare research and publishing. As we navigate the evolving landscape of medical science, events like the Cureus India Symposium play a crucial role in fostering innovation, dialogue, and progress. Cureus remains committed to driving forward the conversation on Open Access and its transformative potential for the global healthcare community.

Mar 14, 2024

Call for Submissions: Nutritional Neurology & Psychiatry - The Gut-Brain Axis

An increasing body of evidence points to a bidirectional interaction between the gut and the brain, mediated by the microbiome, immune system, and other pathways. This gut-brain axis has been implicated in everything from anxiety and depression to Alzheimer's and Parkinson's disease. Cureus requests original research, review articles, technical reports, and case reports elucidating the role of diet, nutrition, probiotics, and the microbiome in neurological and psychiatric conditions. Published articles on this topic will benefit from our unparalleled platforms for dissemination. Our expansive reach across digital channels ensures maximum exposure and impact. To amplify these articles, Cureus will promote them to a wide audience of medical professionals through our social media channels, a dedicated email campaign, and article roundups. Example topics include: Irritable Bowel Syndrome: Treating the Gut and Brain/Mind at the Same Time Gut Biome and Mental Health: Do Probiotics Work? Connecting the Dots: The Interplay Between Stroke and the Gut-Brain Axis Abdominal Migraines: A Rare Adulthood Manifestation of a Typical Childhood Disease Diet Quality and Mental Health Amongst Acute Inpatient Psychiatric Patients Fecal Microbiota Transplantation Role in the Treatment of Alzheimer's Disease: A Systematic Review Please include the keyword "Gut-Brain Axis" in your submission. Submission Deadline: November 17, 2023 We welcome submissions from neurologists, psychiatrists, gastroenterologists, nutritionists, internists and other experts on this fascinating area of research with major clinical implications.

Oct 04, 2023

Call for Submissions Complete: AI and Robotics in Healthcare

We are living through a time of unprecedented innovation and advancement in the realm of artificial intelligence (AI) and robotics. With these advancements, healthcare is undergoing revolutionary changes, bringing about new methodologies, challenges, and opportunities. In light of this evolution, Cureus is calling for submissions of articles focusing on the impact of AI, robotics, or both of these technological advancements in healthcare. How are either or both of these technologies reshaping diagnostics, treatments, patient care, or the medical profession at large? What are the ethical implications, challenges, or limitations faced? How might we anticipate the role of these technologies in future healthcare scenarios? We invite physicians, medical practitioners, researchers, engineers, and others working in this fascinating intersection of technology and health to share their insights, experiences, and findings. We will consider: Original Research Review Articles Technical Reports Case Reports Editorials Example topics could include but are not limited to: The Use of AI in Diagnosing Diseases: Present and Future Robotics in Bariatric Surgery: Benefits, Limitations, and Challenges How AI and Robotics are Improving Patient Care and Experience AI in Medical Imaging: Opportunities and Concerns Ethical Implications of AI and Robotics in Healthcare To be included in this collection, please add the keyword "AI & Robotics in Healthcare" to your submission. All submissions will be featured on our email campaign and newsroom page.  We eagerly anticipate your contributions as we navigate and comprehend the impact of AI and robotics in the ever-evolving landscape of healthcare.

Sep 27, 2023

Call for Submissions - Medical Forensics: True Crime Meets Medicine

The application of medical and scientific expertise to analyze crimes and establish facts in legal cases has long fascinated the public. From determining cause of death and time since death to toxicology testing and DNA analysis, medical forensics provides critical evidence in criminal investigations. Cureus requests original research, review articles, and technical and case reports exploring all aspects of forensic medicine and its role in the justice system. Please include the keyword "Forensic Medicine" in submissions. Submission Deadline: November 10, 2023 Example topics include: ABO Blood Grouping and Rhesus Factor Determination From Dental Pulp Tissue: A Forensic Research   Blood-Based Biomarkers in Traumatic Brain Injury: A Narrative Review With Implications for the Legal System   Homicide-Suicide Partners: A Simulation of Injuries   Estimation of Time Since Death From Potassium Levels in Vitreous Humor in Cases of Unnatural Death: A Facility-Based Cross-Sectional Study   The Use of Volatile Substances in Drug-Facilitated Sexual Assault: A Systematic Review This call welcomes articles from forensic pathologists, psychiatrists, odontologists, toxicologists, dentists, DNA analysts, and other experts on the complex intersection of medicine, science, and criminal justice. Published articles will be promoted through our social media channels, a dedicated email campaign, and article roundups, ensuring maximum impact and exposure to a wide audience of medical professionals. Share your work on this ever-intriguing field!

Sep 25, 2023

Call for Submissions - Advances in Rheumatic Disease Treatments

Rheumatic and musculoskeletal diseases such as rheumatoid arthritis, lupus, and osteoarthritis affect millions of patients worldwide. While often chronic and debilitating, recent years have brought exciting advances in pharmacological treatments and non-pharmacological therapies. Cureus requests original research articles, review articles, technical reports, and case reports that explore novel therapeutic approaches and agents for rheumatic disease management. We aim to provide clinicians with cutting-edge insights into optimized care for this complex patient population. Please include the keyword "Rheumatic Diseases" in your submission. Example topics include: Impact of SARS-CoV-2/COVID-19 on Provision of Medical Care to Patients With Systemic Autoimmune Rheumatic Disease and the Practice of Rheumatology   Pathophysiology, Diagnosis, and Management of Takayasu Arteritis: A Review of Current Advances   Oral Microbiome in Pre-Rheumatoid Arthritis: The Role of Aggregatibacter Actinomycetemcomitans in Bacterial Composition   Dairy Consumption: Does It Make an Impact on Self-Reported Disease Activity of Inflammatory Arthritis? Submission Deadline: October 31, 2023 Published articles will be promoted through our social media channels, a dedicated email campaign, and article roundups, ensuring maximum impact and exposure to a wide audience of medical professionals. Don’t miss this opportunity to share your work on the future of rheumatology.

Sep 05, 2023

Cureus Impact Factor Announcement

We're excited to share a significant milestone with you all. The annual release of Clarivate’s Journal Citation Report (JCR) revealed that The Cureus Journal of Medical Science has been awarded its first Impact Factor (IF). This is a noteworthy achievement for our community, and we are proud to share it with you. Both the 2022 two-year IF and five-year IF are 1.2. These Impact Factors place us in the mid-ranking for medicine, a commendable achievement for a journal that prides itself on inclusivity and accessibility.                                        Impact Factors, alongside other metrics such as turnaround time, downloads and social media mentions can help to provide an overall assessment of journal quality and its research output in the community. Cureus metrics: Average Submission to Publication Time: 33 Days Total 2022 Article Views: 40.5 Million Articles Published for Free: 31% While we celebrate this achievement, we wish to restate that Cureus is a DORA signatory and reaffirm our commitment to assessing individual research articles on their own merits, rather than on an aggregate citation count for the journal. This is why we provide article-level metrics on every article page. We understand the importance of Impact Factor to many in the academic community, and as an academic publisher closely attuned to the needs of the research community, we acknowledge its significance. We believe that our inclusion in the Web of Science, and the subsequent Impact Factors, will be beneficial for many academics whose research output is still measured by metrics such as IF. We hope that, alongside this information, our article-level metrics and transparent publishing process will encourage more physicians and medical researchers to submit their work to Cureus, and thus benefit from broad readership and high-quality peer review. Your contributions, whether as authors, reviewers, or readers, have played a crucial role in this accomplishment. We encourage you to continue with us on our journey to democratize medical publishing. - The Cureus Team

Jun 30, 2023