Similar to other opioids, tramadol may cause side effects such as sleepiness, nausea, constipation, and dizziness. When taken in large amounts or in combination with other substances that depress the central nervous system, such as alcohol or benzodiazepines, it may also occasionally result in more severe adverse effects, such as respiratory depression. When taking tramadol, patients who have a history of substance misuse, respiratory issues, or specific mental health disorders may be more susceptible to these side effects and should be constantly watched.

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