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Alcohol: Mixing hydrocodone with alcohol can intensify its effects and increase the risk of adverse reactions, including respiratory depression.
Other Central Nervous System Depressants: Combining hydrocodone with other medications that depress the central nervous system, such as benzodiazepines or muscle relaxants, can amplify sedation and respiratory depression.
Monoamine Oxidase Inhibitors (MAOIs): Concurrent use of hydrocodone with MAOIs can lead to serotonin syndrome, a potentially life-threatening condition characterized by agitation, confusion, and rapid heart rate.
