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Hydrocodone is a Schedule II semi-synthetic opioid medication approved by the U.S. FDA. It is commonly used for managing severe chronic pain that does not respond well to nonopioid treatments.

It is also used in combination with other medications to treat nonproductive cough in adults, as it has properties that suppress coughing.

It works by enhancing opioid receptors in the body, specifically the mu-opioid receptors, to provide pain relief. As the concentration of the drug in the bloodstream increases, it also activates delta- and kappa-opioid receptors.