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Opana ER (extended-release) is a brand name for the medication oxymorphone hydrochloride, which is a powerful opioid pain reliever. It is primarily used to manage severe pain that requires around-the-clock treatment and cannot be managed with other medications. Opana ER works by binding to opioid receptors in the brain and spinal cord, altering the perception of pain. However, it also carries a high risk of dependence, addiction, and overdose, especially if used improperly or for an extended period. It's important to use Opana ER exactly as prescribed by a healthcare professional and to be aware of its potential for abuse and addiction.