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Lunesta may interact with other medications, especially other central nervous system depressants, and may have additive effects. It is crucial to inform the healthcare provider about all medications, supplements, and medical conditions. Alcohol should be avoided while taking Lunesta, as it can enhance the sedative effects.

Special Populations: The safety of Lunesta in pregnant or breastfeeding individuals is not well-established, and its use should be discussed with a healthcare provider. The medication may impair cognitive and motor functions, affecting the ability to drive or operate machinery.