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Co-occurring Conditions:
Caution is warranted when prescribing tramadol to individuals with a history of substance abuse. They may be at an increased risk of misuse and dependence. Additionally, tramadol should be used cautiously in individuals with respiratory conditions, as it can lead to respiratory depression, particularly at higher doses.

Regulatory Status and Controversies:

Tramadol's regulatory status varies globally. While it is widely available as a prescription medication in many countries, some regions have implemented stricter controls due to concerns about its abuse potential. The drug has been the subject of debates and controversies, with discussions centering around its classification and the need for increased awareness about the risks associated with its use.

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