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Gabapentin was first approved by the US Food and Drug Administration (FDA) as an anticonvulsant (seizures in some cases) and is now widely used to treat neuropathic pain. The mechanism of action of gabapentin is unclear, but it reduces calcium entry by binding to the α2-δ subunit and blocking voltage-gated calcium channels. Gabapentin modulates nociceptive transmission by reducing glutamate and substance P release from primary nociceptive afferents by blocking calcium entry. Gabapentin is used to treat painful neuropathy caused by painful diabetic neuropathy, postherpetic neuralgia, trigeminal neuralgia, complex regional pain syndrome, human immunodeficiency virus (HIV), cancer, multiple sclerosis, and spinal cord injury. . buy gabapentin online