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Buy Hydrocodone online is acts on the central nervous system (CNS) in our brain. Take this medication on a regular schedule as directed by your doctor, not as needed for sudden pain. Take this medication by mouth as directed by your doctor, usually every 12 hours. You may take this drug with or without food. If you have nausea, it may help to take this drug with food. Ask your doctor or pharmacist about other ways to decrease nausea.