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Norco is a combination of Hydrocodone bitartrate and acetaminophen) is supplied in tablet form for oral administration. This combination medication is used to relieve moderate-to-severe pain. It contains an opioid (narcotic) pain reliever (hydrocodone) and a non-opioid pain reliever (acetaminophen). However, Norco works in the brain to change how your body feels and responds to pain.