Lortab is a combination medication that contains acetaminophen and hydrocodone. This medication combination is used to treat pain ranging from moderate to severe. Lortab’s generic name is acetaminophen and hydrocodone and belongs to the drug class narcotic analgesic combination. Acetaminophen is a non-opioid pain reliever and hydrocodone is an opioid pain reliever. In the brain, hydrocodone changes how your body perceives and responds to pain. Acetaminophen can also be used to treat fever. These two ingredients work to relieve the pain the first is hydrocodone is narcotic pain medicine and the second is acetaminophen is a powerful pain reliever that enhances the effect of hydrocodone.