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Acetaminophen and oxycodone is a combination medicine used to relieve moderate to severe pain. Oxycodone acetaminophen 5-325 contains an opioid medicine and may be habit-forming. This medication is a type of analgesic & a type of opiate. It helps to relieve moderate to severe pain. Take this medication with food or without food. If you have nausea, it may help to take this drug with food. It may cause life-threatening breathing problems during the first 24 to 72 hours of your treatment & any time your dose is increased.