Chang Xu
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I am a physician scientist, I have done extensive basic biological research in signal transduction pathways and nephrology.
During my PHD study at UConn Medical center from 1997 to 2003, I studied phospholipid signalling using a combination of cell biology, molecular biology, patch clamp and computational modeling methods. My first authored-paper in the Journal of Cell biology detailing the outcome of this study title “Kinetic analysis of receptor-activated phosphoinositide turnover” was considered essential to our understanding of the phospholipid signaling.
From 2003 to 2008, I conducted basic research on pathophysiology of autosomal dominant polycystic kidney disease (ADPKD) through funding obtained from the National Institutes of Health and the PKD Foundation. I published four first-authored papers while working in Harvard medical School. My work made significant contribution to our understanding of polycystin biology and the role of primary cilia in the pathogenesis of ADPKD.
From 2011 to 2013, while I worked as an assistant professor in the Department of Medicine at University of Chicago, I studied the role of kidney glomerular endothelial cells in acute kidney injury. My first-authored paper published in Kidney International “TNF-mediated damage to glomerular endothelium is an important determinant of acute kidney injury in sepsis” received highly favorable comments from the leading scientists in the field.
I plan to continue to make contribution to our understanding of pathogenesis of ADPKD and sepsis-induced Acute kidney injury.

Reviewer Keywords
general nephrology dialysis and transplanation : acute kidney injury autosomal dominant polycystic kidney mineral bone diseases organ failure from sepsis
Publications (1)

Recent article categories: Internal Medicine, Infectious Disease, Nephrology

My Professional Societies

American Society of Nephrology