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Manuscript Number: ---
Title: Effect of three months honey supplementation on heart rate variability and baroreflex sensitivity in type 2 diabetic neuropathy patients
Review Comments:
• The present study investigates the impact of three months of honey supplementation on cardiovascular autonomic function in patients with type 2 diabetic neuropathy-a patient group at high risk for autonomic imbalance and cardiovascular complications.
• This research offers a unique contribution by assessing non-invasive autonomic function markers such as heart rate variability (HRV), cardiovascular autonomic function tests (CAFT), and baroreflex sensitivity (BRS) in a clinical population, an area that has not been thoroughly explored in human subjects.
• One of the standout features of this study is its novel approach, as it is among the first to evaluate the influence of honey on autonomic cardiovascular control in diabetic neuropathy patients over an extended period.
• The use of well-established and validated physiological measures like HRV and BRS adds credibility to the findings. Furthermore, the study design reflects ethical rigor, with clear inclusion/exclusion criteria, prior registration with the Clinical Trials Registry of India, and oversight by an institutional ethics committee.
• The selection of honey was carefully standardized, ensuring purity and antioxidant potential, which strengthens the internal validity of the intervention. Notably, the significant improvements observed in markers of parasympathetic activity, oxidative stress, lipid profile, and fasting blood glucose collectively indicate a promising cardiometabolic benefit.
