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Combining acetaminophen with oxycodone is a medication used to treat moderate to severe pain. Oxycodone is an opioid medication that has the potential to become addictive. This drug, which helps to relieve moderate to severe pain, is an opiate and an analgesic. Either consume food or not when taking Oxycodone. Taking this medication with meals may help if you experience nausea. Any time your dose is raised or during the first 24 to 72 hours of your therapy, it may result in potentially fatal respiratory difficulties.

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