Cureus | Inhibition of endothelial cell functions and of angiogenesis by the metastasis inhibitor NAMI-A
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Research Article

Inhibition of endothelial cell functions and of angiogenesis by the metastasis inhibitor NAMI-A

A Vacca, M Bruno, A Boccarelli, M Coluccia, D Ribatti, A Bergamo, S Garbisa, L Sartor, G Sava

Published: March 18, 2002

DOI: 10.1038/sj.bjc.6600176

License: Cancer Research UK

Abstract

NAMI-A is a ruthenium-based compound with selective anti-metastasis activity in experimental models of solid tumours. We studied whether this activity was dependent on anti-angiogenic ability of NAMI-A. We thus investigated its in vitro effects on endothelial cell functions necessary for angiogenesis to develop, as well as its in vivo effects in the chick embryo chorioallantoic membrane model. Endothelial cell proliferation, chemotaxis, and secretion of the matrix-degrading enzyme metalloproteinase-2 were inhibited by NAMI-A in a dose-dependent manner, and without morphologic signs of cell apoptosis or necrosis. Lastly, NAMI-A displayed a dose-dependent in vivo anti-angiogenic activity in the chorioallantoic membrane model. These data suggest that the anti-angiogenic activity of NAMI-A can contribute to its anti-metastatic efficacy in mice bearing malignant solid tumours.British Journal of Cancer (2002) 86, 993–998. DOI: 10.1038/sj/bjc/6600176 www.bjcancer.com© 2002 Cancer Research UK


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Scholarly Impact Quotient™ (SIQ™) is our unique post-publication peer review rating process. SIQ™ assesses article importance and quality by embracing the collective intelligence of the Cureus community-at-large. All registered users are invited to contribute to the SIQ™ of any published article. (Authors cannot rate their own articles.)

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