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Case report
peer-reviewed

Pure Squamous Cell Carcinoma of the Gallbladder Masquerading as a Hepatic Mass



Abstract

Gallbladder (GB) carcinomas are adenocarcinomas (AC) in the majority of cases. Adenosquamous carcinoma (ASC) and pure squamous cell carcinoma (SCC) of the gallbladder are rarely encountered and comprise 1-3% of gallbladder cancer cases.  Pure squamous cell carcinoma of the gallbladder is rarer with less than 1% of the incidence. Most of the published literature is based on case reports and case series. The survival rates of ASC and SCC of the gallbladder are significantly lower (mean of five months) compared to the AC of the gallbladder (mean survival of 11.4 months). Most of these lesions are advanced at presentation, rendering them unresectable and resulting in a poor prognosis. However, if the lesions are diagnosed at an early stage, they could potentially be resectable. We report one such rare case of pure SCC GB presenting as a hepatic mass. The patient subsequently underwent resection of the gallbladder and liver mass with complete recovery and is currently planned for chemotherapy and radiation treatment.



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Case report
peer-reviewed

Pure Squamous Cell Carcinoma of the Gallbladder Masquerading as a Hepatic Mass


Author Information

Abhilash Perisetti Corresponding Author

Hospital Medicine, Texas Tech Health Sciences Center Lubbock

Saikiran Raghavapuram

Division of Gastroenterology, University of Arkansas for Medical Sciences

Benjamin Tharian

Division of Gastroenterology, University of Arkansas for Medical Sciences

Irfan Warraich

Department of Pathology, Texas Tech University, Lubbock, Texas, Usa, Texas Tech University Health Sciences Center

Fred Hardwicke

Department of Hematology & Oncology Texas Tech University, Lubbock, Texas, Usa, Texas Tech University Health Sciences Center

Rubayat Rahman

Department of Hospital Medicine, University Medical Centre

Edwin Onkendi

Department of Surgery, Texas Tech University, Lubbock, Texas, Usa, Texas Tech University Health Sciences Center


Ethics Statement and Conflict of Interest Disclosures

Human subjects: Consent was obtained by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.


Case report
peer-reviewed

Pure Squamous Cell Carcinoma of the Gallbladder Masquerading as a Hepatic Mass


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Case report
peer-reviewed

Pure Squamous Cell Carcinoma of the Gallbladder Masquerading as a Hepatic Mass

  • Author Information
    Abhilash Perisetti Corresponding Author

    Hospital Medicine, Texas Tech Health Sciences Center Lubbock

    Saikiran Raghavapuram

    Division of Gastroenterology, University of Arkansas for Medical Sciences

    Benjamin Tharian

    Division of Gastroenterology, University of Arkansas for Medical Sciences

    Irfan Warraich

    Department of Pathology, Texas Tech University, Lubbock, Texas, Usa, Texas Tech University Health Sciences Center

    Fred Hardwicke

    Department of Hematology & Oncology Texas Tech University, Lubbock, Texas, Usa, Texas Tech University Health Sciences Center

    Rubayat Rahman

    Department of Hospital Medicine, University Medical Centre

    Edwin Onkendi

    Department of Surgery, Texas Tech University, Lubbock, Texas, Usa, Texas Tech University Health Sciences Center


    Ethics Statement and Conflict of Interest Disclosures

    Human subjects: Consent was obtained by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

    Acknowledgements


    Article Information

    Published: January 01, 2018

    DOI

    10.7759/cureus.2011

    Cite this article as:

    Perisetti A, Raghavapuram S, Tharian B, et al. (January 01, 2018) Pure Squamous Cell Carcinoma of the Gallbladder Masquerading as a Hepatic Mass. Cureus 10(1): e2011. doi:10.7759/cureus.2011

    Publication history

    Received by Cureus: November 06, 2017
    Peer review began: November 10, 2017
    Peer review concluded: December 25, 2017
    Published: January 01, 2018

    Copyright

    © Copyright 2018
    Perisetti et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 3.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

    License

    This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Gallbladder (GB) carcinomas are adenocarcinomas (AC) in the majority of cases. Adenosquamous carcinoma (ASC) and pure squamous cell carcinoma (SCC) of the gallbladder are rarely encountered and comprise 1-3% of gallbladder cancer cases.  Pure squamous cell carcinoma of the gallbladder is rarer with less than 1% of the incidence. Most of the published literature is based on case reports and case series. The survival rates of ASC and SCC of the gallbladder are significantly lower (mean of five months) compared to the AC of the gallbladder (mean survival of 11.4 months). Most of these lesions are advanced at presentation, rendering them unresectable and resulting in a poor prognosis. However, if the lesions are diagnosed at an early stage, they could potentially be resectable. We report one such rare case of pure SCC GB presenting as a hepatic mass. The patient subsequently underwent resection of the gallbladder and liver mass with complete recovery and is currently planned for chemotherapy and radiation treatment.



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Create a free account to continue reading this article.

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Abhilash Perisetti, M.D., Assistant Professor

Hospital Medicine, Texas Tech Health Sciences Center Lubbock

For correspondence:
abhilash.perisetti@gmail.com

Saikiran Raghavapuram

Division of Gastroenterology, University of Arkansas for Medical Sciences

Benjamin Tharian

Division of Gastroenterology, University of Arkansas for Medical Sciences

Irfan Warraich

Department of Pathology, Texas Tech University, Lubbock, Texas, Usa, Texas Tech University Health Sciences Center

Fred Hardwicke

Department of Hematology & Oncology Texas Tech University, Lubbock, Texas, Usa, Texas Tech University Health Sciences Center

Rubayat Rahman, M.D.

Department of Hospital Medicine, University Medical Centre

Edwin Onkendi

Department of Surgery, Texas Tech University, Lubbock, Texas, Usa, Texas Tech University Health Sciences Center

Abhilash Perisetti, M.D., Assistant Professor

Hospital Medicine, Texas Tech Health Sciences Center Lubbock

For correspondence:
abhilash.perisetti@gmail.com

Saikiran Raghavapuram

Division of Gastroenterology, University of Arkansas for Medical Sciences

Benjamin Tharian

Division of Gastroenterology, University of Arkansas for Medical Sciences

Irfan Warraich

Department of Pathology, Texas Tech University, Lubbock, Texas, Usa, Texas Tech University Health Sciences Center

Fred Hardwicke

Department of Hematology & Oncology Texas Tech University, Lubbock, Texas, Usa, Texas Tech University Health Sciences Center

Rubayat Rahman, M.D.

Department of Hospital Medicine, University Medical Centre

Edwin Onkendi

Department of Surgery, Texas Tech University, Lubbock, Texas, Usa, Texas Tech University Health Sciences Center