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Case report
peer-reviewed

Combination Therapy for Multidrug-Resistant Klebsiella Pneumoniae Urinary Tract Infection



Abstract

Hospital-acquired multidrug-resistant (MDR) Klebsiella infection is posing a significant challenge to physicians all around the world. The spread of multiple antibiotic resistance among various members of bacteria continues to be a significant clinical threat. Antibiotic susceptibility testing is the initial step in optimizing the appropriate antibiotic therapy for infections with MDR Klebsiella. We report a case of MDR Klebsiella urinary tract infection (UTI) in a patient following a trimalleolar fracture, which was appropriately treated with a combination of amikacin and meropenem.



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Case report
peer-reviewed

Combination Therapy for Multidrug-Resistant Klebsiella Pneumoniae Urinary Tract Infection


Author Information

Faizan Yasin Corresponding Author

Neurology, State University of New York at Buffalo

Salman Assad

Department of Medicine, Shifa International Hospital, Islamabad, Pakistan

Abdul Subhan Talpur

Medicine, Liaquat University of Medical and Health Sciences

Mehr Zahid

Internal Medicine, University of Lahore, Lahore, Pakistan

Shuja A. Malik

Internal Medicine, Nawaz Sharif Medical College, University of Gujrat


Ethics Statement and Conflict of Interest Disclosures

Human subjects: Consent was obtained by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.


Case report
peer-reviewed

Combination Therapy for Multidrug-Resistant Klebsiella Pneumoniae Urinary Tract Infection


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Case report
peer-reviewed

Combination Therapy for Multidrug-Resistant Klebsiella Pneumoniae Urinary Tract Infection

Faizan Yasin">Faizan Yasin , Salman Assad">Salman Assad, Abdul Subhan Talpur">Abdul Subhan Talpur, Mehr Zahid">Mehr Zahid, Shuja A. Malik">Shuja A. Malik

  • Author Information
    Faizan Yasin Corresponding Author

    Neurology, State University of New York at Buffalo

    Salman Assad

    Department of Medicine, Shifa International Hospital, Islamabad, Pakistan

    Abdul Subhan Talpur

    Medicine, Liaquat University of Medical and Health Sciences

    Mehr Zahid

    Internal Medicine, University of Lahore, Lahore, Pakistan

    Shuja A. Malik

    Internal Medicine, Nawaz Sharif Medical College, University of Gujrat


    Ethics Statement and Conflict of Interest Disclosures

    Human subjects: Consent was obtained by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

    Acknowledgements


    Article Information

    Published: July 22, 2017

    DOI

    10.7759/cureus.1503

    Cite this article as:

    Yasin F, Assad S, Talpur A, et al. (July 22, 2017) Combination Therapy for Multidrug-Resistant Klebsiella Pneumoniae Urinary Tract Infection. Cureus 9(7): e1503. doi:10.7759/cureus.1503

    Publication history

    Received by Cureus: June 22, 2017
    Peer review began: July 12, 2017
    Peer review concluded: July 12, 2017
    Published: July 22, 2017

    Copyright

    © Copyright 2017
    Yasin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 3.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

    License

    This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Hospital-acquired multidrug-resistant (MDR) Klebsiella infection is posing a significant challenge to physicians all around the world. The spread of multiple antibiotic resistance among various members of bacteria continues to be a significant clinical threat. Antibiotic susceptibility testing is the initial step in optimizing the appropriate antibiotic therapy for infections with MDR Klebsiella. We report a case of MDR Klebsiella urinary tract infection (UTI) in a patient following a trimalleolar fracture, which was appropriately treated with a combination of amikacin and meropenem.



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Create a free account to continue reading this article.

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Faizan Yasin, M.D.

Neurology, State University of New York at Buffalo

For correspondence:
faizanyasin62@gmail.com

Salman Assad, M.D.

Department of Medicine, Shifa International Hospital, Islamabad, Pakistan

Abdul Subhan Talpur

Medicine, Liaquat University of Medical and Health Sciences

Mehr Zahid

Internal Medicine, University of Lahore, Lahore, Pakistan

Shuja A. Malik, Medical Student

Internal Medicine, Nawaz Sharif Medical College, University of Gujrat

Faizan Yasin, M.D.

Neurology, State University of New York at Buffalo

For correspondence:
faizanyasin62@gmail.com

Salman Assad, M.D.

Department of Medicine, Shifa International Hospital, Islamabad, Pakistan

Abdul Subhan Talpur

Medicine, Liaquat University of Medical and Health Sciences

Mehr Zahid

Internal Medicine, University of Lahore, Lahore, Pakistan

Shuja A. Malik, Medical Student

Internal Medicine, Nawaz Sharif Medical College, University of Gujrat