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Review article
peer-reviewed

The Interplay of Genetics and Environmental Factors in the Development of Obesity



Abstract

Obesity is a major health issue in the developed nations, and it has been increasingly clear that both genetics and environment play an important role in determining if an individual will be obese or not. We reviewed the latest researches which were carried out to identify the obesity susceptible genes and to identify the metabolic pathways having a central role in energy balance. Obesity is a heritable disorder, and some of the many obesity susceptible genes are fat mass and obesity (FTO), leptin, and Melanocortin-4 receptor (MC4R). Glucose metabolism is the central pathway for fatty acid synthesis, de novo generating the major substrate acetyl-CoA. Further knowledge of these genes and their complex interaction with the environment will help devise individual, family and community-based preventive lifestyle interventions as well as nutritional and medical therapies.



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Review article
peer-reviewed

The Interplay of Genetics and Environmental Factors in the Development of Obesity


Author Information

Abu Baker Sheikh Corresponding Author

Department of Internal Medicine, Shifa International Hospital

Adeel Nasrullah

Department of Internal Medicine, Shifa International Hospital

Department of Medicine, MH Rawalpindi

Department of Surgery, MH Rawalpindi

Shujaul Haq

Department of Internal Medicine, Shifa International Hospital

Aisha Akhtar

Surgery, Texas Tech Health Sciences Center Lubbock

Haider Ghazanfar

Internal Medicine, Newark Beth Israel Medical Center

Amara Nasir

Shifa College of Medicine, Shifa International Hospital

Rao M. Afzal

Internal Medicine, Shifa College Of Medicine

Marvi M. Bukhari

Internal Medicine, Shifa College Of Medicine

Ahtsham Yousaf Chaudhary

Shifa College Of Medicine

Syed W. Naqvi

Shifa College of Medicine, Shifa International Hospital


Ethics Statement and Conflict of Interest Disclosures

Conflicts of interest: The authors have declared that no conflicts of interest exist.


Review article
peer-reviewed

The Interplay of Genetics and Environmental Factors in the Development of Obesity


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Review article
peer-reviewed

The Interplay of Genetics and Environmental Factors in the Development of Obesity

  • Author Information
    Abu Baker Sheikh Corresponding Author

    Department of Internal Medicine, Shifa International Hospital

    Adeel Nasrullah

    Department of Internal Medicine, Shifa International Hospital

    Department of Medicine, MH Rawalpindi

    Department of Surgery, MH Rawalpindi

    Shujaul Haq

    Department of Internal Medicine, Shifa International Hospital

    Aisha Akhtar

    Surgery, Texas Tech Health Sciences Center Lubbock

    Haider Ghazanfar

    Internal Medicine, Newark Beth Israel Medical Center

    Amara Nasir

    Shifa College of Medicine, Shifa International Hospital

    Rao M. Afzal

    Internal Medicine, Shifa College Of Medicine

    Marvi M. Bukhari

    Internal Medicine, Shifa College Of Medicine

    Ahtsham Yousaf Chaudhary

    Shifa College Of Medicine

    Syed W. Naqvi

    Shifa College of Medicine, Shifa International Hospital


    Ethics Statement and Conflict of Interest Disclosures

    Conflicts of interest: The authors have declared that no conflicts of interest exist.

    Acknowledgements


    Article Information

    Published: July 06, 2017

    DOI

    10.7759/cureus.1435

    Cite this article as:

    Sheikh A, Nasrullah A, Haq S, et al. (July 06, 2017) The Interplay of Genetics and Environmental Factors in the Development of Obesity. Cureus 9(7): e1435. doi:10.7759/cureus.1435

    Publication history

    Received by Cureus: June 10, 2017
    Peer review began: June 24, 2017
    Peer review concluded: June 25, 2017
    Published: July 06, 2017

    Copyright

    © Copyright 2017
    Sheikh et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 3.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

    License

    This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Obesity is a major health issue in the developed nations, and it has been increasingly clear that both genetics and environment play an important role in determining if an individual will be obese or not. We reviewed the latest researches which were carried out to identify the obesity susceptible genes and to identify the metabolic pathways having a central role in energy balance. Obesity is a heritable disorder, and some of the many obesity susceptible genes are fat mass and obesity (FTO), leptin, and Melanocortin-4 receptor (MC4R). Glucose metabolism is the central pathway for fatty acid synthesis, de novo generating the major substrate acetyl-CoA. Further knowledge of these genes and their complex interaction with the environment will help devise individual, family and community-based preventive lifestyle interventions as well as nutritional and medical therapies.



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Create a free account to continue reading this article.

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Abu Baker Sheikh, M.D.

Department of Internal Medicine, Shifa International Hospital

For correspondence:
abubaker.sheikh@gmail.com

Adeel Nasrullah, M.D.

Department of Internal Medicine, Shifa International Hospital

Shujaul Haq

Department of Internal Medicine, Shifa International Hospital

Aisha Akhtar

Surgery, Texas Tech Health Sciences Center Lubbock

Haider Ghazanfar

Internal Medicine, Newark Beth Israel Medical Center

Amara Nasir

Shifa College of Medicine, Shifa International Hospital

Rao M. Afzal

Internal Medicine, Shifa College Of Medicine

Marvi M. Bukhari

Internal Medicine, Shifa College Of Medicine

Ahtsham Yousaf Chaudhary

Shifa College Of Medicine

Syed W. Naqvi

Shifa College of Medicine, Shifa International Hospital

Abu Baker Sheikh, M.D.

Department of Internal Medicine, Shifa International Hospital

For correspondence:
abubaker.sheikh@gmail.com

Adeel Nasrullah, M.D.

Department of Internal Medicine, Shifa International Hospital

Shujaul Haq

Department of Internal Medicine, Shifa International Hospital

Aisha Akhtar

Surgery, Texas Tech Health Sciences Center Lubbock

Haider Ghazanfar

Internal Medicine, Newark Beth Israel Medical Center

Amara Nasir

Shifa College of Medicine, Shifa International Hospital

Rao M. Afzal

Internal Medicine, Shifa College Of Medicine

Marvi M. Bukhari

Internal Medicine, Shifa College Of Medicine

Ahtsham Yousaf Chaudhary

Shifa College Of Medicine

Syed W. Naqvi

Shifa College of Medicine, Shifa International Hospital