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Case report
peer-reviewed

Ischemic Stroke Presenting as the First Symptom in a Setting of Paroxysmal Nocturnal Hemoglobinuria



Abstract

Paroxysmal nocturnal hemoglobinuria is a hematological disorder characterized by hemolytic anemia, cytopenia, and thrombotic events. Venous thrombotic events are more commonly reported. An arterial thrombosis is a rare event in paroxysmal nocturnal hemoglobinuria. We present a case of a 32-year-old female who had symptoms of stroke and on workup, she was diagnosed as a case of paroxysmal nocturnal hemoglobinuria. 



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Case report
peer-reviewed

Ischemic Stroke Presenting as the First Symptom in a Setting of Paroxysmal Nocturnal Hemoglobinuria


Author Information

Muhammad Junaid Ahsan Corresponding Author

Medicine, Interfaith Medical Centre

Rizwan Ishtiaq

Gastroenterology, Beth Israel Deaconess Medical Center, Boston

Daniyal Ishtiaq

General Medicine, Rawalpindi Medical College, Rawalpindi, Pakistan


Ethics Statement and Conflict of Interest Disclosures

Human subjects: Consent was obtained by all participants in this study. Services Institute of Medical Sciences issued approval 112. Conflicts of interest: The authors have declared that no conflicts of interest exist.


Case report
peer-reviewed

Ischemic Stroke Presenting as the First Symptom in a Setting of Paroxysmal Nocturnal Hemoglobinuria


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Case report
peer-reviewed

Ischemic Stroke Presenting as the First Symptom in a Setting of Paroxysmal Nocturnal Hemoglobinuria

  • Author Information
    Muhammad Junaid Ahsan Corresponding Author

    Medicine, Interfaith Medical Centre

    Rizwan Ishtiaq

    Gastroenterology, Beth Israel Deaconess Medical Center, Boston

    Daniyal Ishtiaq

    General Medicine, Rawalpindi Medical College, Rawalpindi, Pakistan


    Ethics Statement and Conflict of Interest Disclosures

    Human subjects: Consent was obtained by all participants in this study. Services Institute of Medical Sciences issued approval 112. Conflicts of interest: The authors have declared that no conflicts of interest exist.

    Acknowledgements


    Article Information

    Published: July 07, 2017

    DOI

    10.7759/cureus.1439

    Cite this article as:

    Ahsan M, Ishtiaq R, Ishtiaq D (July 07, 2017) Ischemic Stroke Presenting as the First Symptom in a Setting of Paroxysmal Nocturnal Hemoglobinuria. Cureus 9(7): e1439. doi:10.7759/cureus.1439

    Publication history

    Received by Cureus: June 04, 2017
    Peer review began: June 29, 2017
    Peer review concluded: June 29, 2017
    Published: July 07, 2017

    Copyright

    © Copyright 2017
    Ahsan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 3.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

    License

    This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Paroxysmal nocturnal hemoglobinuria is a hematological disorder characterized by hemolytic anemia, cytopenia, and thrombotic events. Venous thrombotic events are more commonly reported. An arterial thrombosis is a rare event in paroxysmal nocturnal hemoglobinuria. We present a case of a 32-year-old female who had symptoms of stroke and on workup, she was diagnosed as a case of paroxysmal nocturnal hemoglobinuria. 



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Muhammad Junaid Ahsan

Medicine, Interfaith Medical Centre

For correspondence:
junaidahsan333@gmail.com

Rizwan Ishtiaq, M.D.

Gastroenterology, Beth Israel Deaconess Medical Center, Boston

Daniyal Ishtiaq

General Medicine, Rawalpindi Medical College, Rawalpindi, Pakistan

Muhammad Junaid Ahsan

Medicine, Interfaith Medical Centre

For correspondence:
junaidahsan333@gmail.com

Rizwan Ishtiaq, M.D.

Gastroenterology, Beth Israel Deaconess Medical Center, Boston

Daniyal Ishtiaq

General Medicine, Rawalpindi Medical College, Rawalpindi, Pakistan