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Case report
peer-reviewed

Consanguinity Associated with Increased Prevalence and Severity of Bipolar Disorder in Pakistan: A Case Report Highlighting the Genetic Link



Abstract

This case report highlights the genetic link associated with bipolar disorder and rising prevalence of such cases in Pakistan due to the lack of knowledge and understanding of the disease. It also shows that a family history of bipolar disorder is associated with more aggressive episodes, early onset, and treatment relapse. Further studies are warranted to fully understand the pathophysiology of genetic linkages causing bipolar disorder so we can understand the natural course of illness and provide effective treatment. We report the case of a 25-year-old girl who presented to the hospital with severe mania and had around 20 episodes of acute mania in the last ten years. Her parents (first cousins) and brother all had a diagnosis of bipolar disorder.



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Case report
peer-reviewed

Consanguinity Associated with Increased Prevalence and Severity of Bipolar Disorder in Pakistan: A Case Report Highlighting the Genetic Link


Author Information

Muhammad Aadil

Department of Medicine, FMH College of Medicine

Aitzaz Munir

Department of Psychiatry, Howard University Hospital

Hasnain Arshad

Department of Internal Medicine, Howard University Hospital

Feham Tariq

Internal Medicine, Services Hospital

Muhammad Jahanzaib Anwar Corresponding Author

Department of Internal Medicine, Rush University Medical Center

Department of Ophthalmology, Bahawal Victoria Hospital, Bahawalpur, Pakistan

Noman Amjad

Psychiatry Department, Nishtar Hospital

Anum Akhlaq

Department of Medicine, FMH College of Medicine and Dentistry


Ethics Statement and Conflict of Interest Disclosures

Human subjects: Consent was obtained by all participants in this study. Conflicts of interest: The authors have declared that no conflicts of interest exist.


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Case report
peer-reviewed

Consanguinity Associated with Increased Prevalence and Severity of Bipolar Disorder in Pakistan: A Case Report Highlighting the Genetic Link

  • Author Information
    Muhammad Aadil

    Department of Medicine, FMH College of Medicine

    Aitzaz Munir

    Department of Psychiatry, Howard University Hospital

    Hasnain Arshad

    Department of Internal Medicine, Howard University Hospital

    Feham Tariq

    Internal Medicine, Services Hospital

    Muhammad Jahanzaib Anwar Corresponding Author

    Department of Internal Medicine, Rush University Medical Center

    Department of Ophthalmology, Bahawal Victoria Hospital, Bahawalpur, Pakistan

    Noman Amjad

    Psychiatry Department, Nishtar Hospital

    Anum Akhlaq

    Department of Medicine, FMH College of Medicine and Dentistry


    Ethics Statement and Conflict of Interest Disclosures

    Human subjects: Consent was obtained by all participants in this study. Conflicts of interest: The authors have declared that no conflicts of interest exist.

    Acknowledgements


    Article Information

    Published: July 13, 2017

    DOI

    10.7759/cureus.1467

    Cite this article as:

    Aadil M, Munir A, Arshad H, et al. (July 13, 2017) Consanguinity Associated with Increased Prevalence and Severity of Bipolar Disorder in Pakistan: A Case Report Highlighting the Genetic Link. Cureus 9(7): e1467. doi:10.7759/cureus.1467

    Publication history

    Received by Cureus: June 02, 2017
    Peer review began: June 19, 2017
    Peer review concluded: June 30, 2017
    Published: July 13, 2017

    Copyright

    © Copyright 2017
    Aadil et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 3.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

    License

    This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

This case report highlights the genetic link associated with bipolar disorder and rising prevalence of such cases in Pakistan due to the lack of knowledge and understanding of the disease. It also shows that a family history of bipolar disorder is associated with more aggressive episodes, early onset, and treatment relapse. Further studies are warranted to fully understand the pathophysiology of genetic linkages causing bipolar disorder so we can understand the natural course of illness and provide effective treatment. We report the case of a 25-year-old girl who presented to the hospital with severe mania and had around 20 episodes of acute mania in the last ten years. Her parents (first cousins) and brother all had a diagnosis of bipolar disorder.



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Create a free account to continue reading this article.

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Muhammad Aadil

Department of Medicine, FMH College of Medicine

Aitzaz Munir, M.D.

Department of Psychiatry, Howard University Hospital

Hasnain Arshad

Department of Internal Medicine, Howard University Hospital

Feham Tariq

Internal Medicine, Services Hospital

Muhammad Jahanzaib Anwar

Department of Internal Medicine, Rush University Medical Center

For correspondence:
docjazzya@gmail.com

Noman Amjad

Psychiatry Department, Nishtar Hospital

Anum Akhlaq

Department of Medicine, FMH College of Medicine and Dentistry

Muhammad Aadil

Department of Medicine, FMH College of Medicine

Aitzaz Munir, M.D.

Department of Psychiatry, Howard University Hospital

Hasnain Arshad

Department of Internal Medicine, Howard University Hospital

Feham Tariq

Internal Medicine, Services Hospital

Muhammad Jahanzaib Anwar

Department of Internal Medicine, Rush University Medical Center

For correspondence:
docjazzya@gmail.com

Noman Amjad

Psychiatry Department, Nishtar Hospital

Anum Akhlaq

Department of Medicine, FMH College of Medicine and Dentistry