"Never doubt that a small group of thoughtful, committed citizens can change the world. Indeed, it is the only thing that ever has."

Margaret Mead
Original article
peer-reviewed

Correlation of TP53 Overexpression and Clinical Parameters with Five-Year Survival in Oral Squamous Cell Carcinoma Patients



Abstract

Introduction

TP53 mutation and overexpression have been correlated with poor survival in many cancers including oral squamous cell carcinoma (OSCC). We aim to understand the role of TP53 overexpression in OSCC in our population and correlate it with five-year survival to test its viability as a prognostic marker for OSCC patients.

Materials and methods

Patients with biopsy proven OSCC at Aga Khan University Hospital from January 2000 to January 2008 were recruited. Immunohistochemistry was used to establish TP53 status and the results were published. Following up on these patients, five-year data were collected and correlated with TP53 status and other clinicopathologic parameters.

Results

Overexpression of TP53 was not significantly associated with five-year survival (hazard ratio [HR]: 1.543; 95% CI: 0.911-2.612; p = 0.107).

Conclusion

Although we had proven statistical relevance when correlated with overall survival in our previous study, we were unable to extend the same relevance to TP53 overexpression when it comes to five-year survival.



Want to read more?

Create a free account to continue reading this article.

Already a member? Login.



Original article
peer-reviewed

Correlation of TP53 Overexpression and Clinical Parameters with Five-Year Survival in Oral Squamous Cell Carcinoma Patients


Author Information

Syed A. Ali

Surgery, The Aga Khan University

Hamza A. Khan

Medical College, The Aga Khan University

Omar Irfan Corresponding Author

Medicine, The Aga Khan University

Adeel Samad

Medical College, The Aga Khan University

Yumna Mirza

Surgery, The Aga Khan University

Muhammad S. Awan

Surgery, The Aga Khan University


Ethics Statement and Conflict of Interest Disclosures

Human subjects: Consent was obtained by all participants in this study. The study was approved by the Ethical Review Committee at AKUH and written informed consent was taken from all patients prior to their induction in the study. Animal subjects: This study did not involve animal subjects or tissue. Conflicts of interest: The authors have declared the following conflicts of interest: Payment/services info: This study was supported by a grant from university research council, the Aga Khan University, Karachi, Pakistan. Grant ID: 031018SURG.

Acknowledgements

This study was supported by a grant from university research council, the Aga Khan University, Karachi, Pakistan. Grant ID: 031018SURG.


Original article
peer-reviewed

Correlation of TP53 Overexpression and Clinical Parameters with Five-Year Survival in Oral Squamous Cell Carcinoma Patients


Figures etc.

Share
Original article
peer-reviewed

Correlation of TP53 Overexpression and Clinical Parameters with Five-Year Survival in Oral Squamous Cell Carcinoma Patients

  • Author Information
    Syed A. Ali

    Surgery, The Aga Khan University

    Hamza A. Khan

    Medical College, The Aga Khan University

    Omar Irfan Corresponding Author

    Medicine, The Aga Khan University

    Adeel Samad

    Medical College, The Aga Khan University

    Yumna Mirza

    Surgery, The Aga Khan University

    Muhammad S. Awan

    Surgery, The Aga Khan University


    Ethics Statement and Conflict of Interest Disclosures

    Human subjects: Consent was obtained by all participants in this study. The study was approved by the Ethical Review Committee at AKUH and written informed consent was taken from all patients prior to their induction in the study. Animal subjects: This study did not involve animal subjects or tissue. Conflicts of interest: The authors have declared the following conflicts of interest: Payment/services info: This study was supported by a grant from university research council, the Aga Khan University, Karachi, Pakistan. Grant ID: 031018SURG.

    Acknowledgements

    This study was supported by a grant from university research council, the Aga Khan University, Karachi, Pakistan. Grant ID: 031018SURG.


    Article Information

    Published: June 27, 2017

    DOI

    10.7759/cureus.1401

    Cite this article as:

    Ali S A, Khan H A, Irfan O, et al. (June 27, 2017) Correlation of TP53 Overexpression and Clinical Parameters with Five-Year Survival in Oral Squamous Cell Carcinoma Patients. Cureus 9(6): e1401. doi:10.7759/cureus.1401

    Publication history

    Received by Cureus: May 28, 2017
    Peer review began: June 07, 2017
    Peer review concluded: June 18, 2017
    Published: June 27, 2017

    Copyright

    © Copyright 2017
    Ali et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 3.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

    License

    This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Introduction

TP53 mutation and overexpression have been correlated with poor survival in many cancers including oral squamous cell carcinoma (OSCC). We aim to understand the role of TP53 overexpression in OSCC in our population and correlate it with five-year survival to test its viability as a prognostic marker for OSCC patients.

Materials and methods

Patients with biopsy proven OSCC at Aga Khan University Hospital from January 2000 to January 2008 were recruited. Immunohistochemistry was used to establish TP53 status and the results were published. Following up on these patients, five-year data were collected and correlated with TP53 status and other clinicopathologic parameters.

Results

Overexpression of TP53 was not significantly associated with five-year survival (hazard ratio [HR]: 1.543; 95% CI: 0.911-2.612; p = 0.107).

Conclusion

Although we had proven statistical relevance when correlated with overall survival in our previous study, we were unable to extend the same relevance to TP53 overexpression when it comes to five-year survival.



Want to read more?

Create a free account to continue reading this article.

Already a member? Login.



Syed A. Ali

Surgery, The Aga Khan University

Hamza A. Khan

Medical College, The Aga Khan University

Omar Irfan

Medicine, The Aga Khan University

For correspondence:
omarirfan1@hotmail.com

Adeel Samad

Medical College, The Aga Khan University

Yumna Mirza

Surgery, The Aga Khan University

Muhammad S. Awan

Surgery, The Aga Khan University

Syed A. Ali

Surgery, The Aga Khan University

Hamza A. Khan

Medical College, The Aga Khan University

Omar Irfan

Medicine, The Aga Khan University

For correspondence:
omarirfan1@hotmail.com

Adeel Samad

Medical College, The Aga Khan University

Yumna Mirza

Surgery, The Aga Khan University

Muhammad S. Awan

Surgery, The Aga Khan University