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Case report
peer-reviewed

Breast Cancer Metastases to the Gastrointestinal Tract Presenting with Anemia and Intra-abdominal Bleed



Abstract

Signet ring adenocarcinoma of the breast with synchronous metastasis to the gastrointestinal (GI) tract is a rare occurrence, typically presenting with abdominal pain, dyspepsia, or GI bleed. We report a case of metastatic breast cancer presenting with a complaint of anemia. A further diagnostic evaluation revealed generalized lymphadenopathy, nodular thickening of the urinary bladder wall, bone lesions, and enlarged pancreas. Biopsies from the lymph nodes, pancreatic biopsy, and bladder nodule all revealed a signet cell carcinoma. An upper and lower GI endoscopy revealed multiple ulcerated gastric mucosal nodules and polypoid folds in the cecum and proximal ascending colon; the biopsies from these lesions were also positive for signet ring cell adenocarcinoma.



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Case report
peer-reviewed

Breast Cancer Metastases to the Gastrointestinal Tract Presenting with Anemia and Intra-abdominal Bleed


Author Information

Idrees Khan

Center for Healthcare Advancement & Outcomes Research, Baptist Health Medical Group

Rehan Malik

Internal Medicine, Mount Sinai Medical Center, Miami Beach, Florida,

Amina Khan Corresponding Author

Shifa Tameer E Millat University, Shifa International Hospital, Islamabad, Pakistan

Salman Assad

Department of Medicine, Shifa International Hospital, Islamabad, Pakistan

Mehr Zahid

Internal Medicine, University of Lahore, Lahore, Pakistan

Muhammad Saad Sohail

Internal Medicine, Shifa International Hospital, Islamabad, Pakistan

Faizan Yasin

Department of Medicine, Shifa Tameer-e-Millat University

Ahmed H. Qavi

Department of Medicine, Mahroof Hospital


Ethics Statement and Conflict of Interest Disclosures

Human subjects: Consent was obtained by all participants in this study. Conflicts of interest: The authors have declared that no conflicts of interest exist.


Case report
peer-reviewed

Breast Cancer Metastases to the Gastrointestinal Tract Presenting with Anemia and Intra-abdominal Bleed


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Case report
peer-reviewed

Breast Cancer Metastases to the Gastrointestinal Tract Presenting with Anemia and Intra-abdominal Bleed

  • Author Information
    Idrees Khan

    Center for Healthcare Advancement & Outcomes Research, Baptist Health Medical Group

    Rehan Malik

    Internal Medicine, Mount Sinai Medical Center, Miami Beach, Florida,

    Amina Khan Corresponding Author

    Shifa Tameer E Millat University, Shifa International Hospital, Islamabad, Pakistan

    Salman Assad

    Department of Medicine, Shifa International Hospital, Islamabad, Pakistan

    Mehr Zahid

    Internal Medicine, University of Lahore, Lahore, Pakistan

    Muhammad Saad Sohail

    Internal Medicine, Shifa International Hospital, Islamabad, Pakistan

    Faizan Yasin

    Department of Medicine, Shifa Tameer-e-Millat University

    Ahmed H. Qavi

    Department of Medicine, Mahroof Hospital


    Ethics Statement and Conflict of Interest Disclosures

    Human subjects: Consent was obtained by all participants in this study. Conflicts of interest: The authors have declared that no conflicts of interest exist.

    Acknowledgements


    Article Information

    Published: July 06, 2017

    DOI

    10.7759/cureus.1429

    Cite this article as:

    Khan I, Malik R, Khan A, et al. (July 06, 2017) Breast Cancer Metastases to the Gastrointestinal Tract Presenting with Anemia and Intra-abdominal Bleed. Cureus 9(7): e1429. doi:10.7759/cureus.1429

    Publication history

    Received by Cureus: June 10, 2017
    Peer review began: June 22, 2017
    Peer review concluded: June 26, 2017
    Published: July 06, 2017

    Copyright

    © Copyright 2017
    Khan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 3.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

    License

    This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Signet ring adenocarcinoma of the breast with synchronous metastasis to the gastrointestinal (GI) tract is a rare occurrence, typically presenting with abdominal pain, dyspepsia, or GI bleed. We report a case of metastatic breast cancer presenting with a complaint of anemia. A further diagnostic evaluation revealed generalized lymphadenopathy, nodular thickening of the urinary bladder wall, bone lesions, and enlarged pancreas. Biopsies from the lymph nodes, pancreatic biopsy, and bladder nodule all revealed a signet cell carcinoma. An upper and lower GI endoscopy revealed multiple ulcerated gastric mucosal nodules and polypoid folds in the cecum and proximal ascending colon; the biopsies from these lesions were also positive for signet ring cell adenocarcinoma.



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Create a free account to continue reading this article.

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Idrees Khan

Center for Healthcare Advancement & Outcomes Research, Baptist Health Medical Group

Rehan Malik

Internal Medicine, Mount Sinai Medical Center, Miami Beach, Florida,

Amina Khan

Shifa Tameer E Millat University, Shifa International Hospital, Islamabad, Pakistan

For correspondence:
aminakhan4_9@hotmail.com

Salman Assad, M.D.

Department of Medicine, Shifa International Hospital, Islamabad, Pakistan

Mehr Zahid

Internal Medicine, University of Lahore, Lahore, Pakistan

Muhammad Saad Sohail

Internal Medicine, Shifa International Hospital, Islamabad, Pakistan

Faizan Yasin

Department of Medicine, Shifa Tameer-e-Millat University

Ahmed H. Qavi, M.D.

Department of Medicine, Mahroof Hospital

Idrees Khan

Center for Healthcare Advancement & Outcomes Research, Baptist Health Medical Group

Rehan Malik

Internal Medicine, Mount Sinai Medical Center, Miami Beach, Florida,

Amina Khan

Shifa Tameer E Millat University, Shifa International Hospital, Islamabad, Pakistan

For correspondence:
aminakhan4_9@hotmail.com

Salman Assad, M.D.

Department of Medicine, Shifa International Hospital, Islamabad, Pakistan

Mehr Zahid

Internal Medicine, University of Lahore, Lahore, Pakistan

Muhammad Saad Sohail

Internal Medicine, Shifa International Hospital, Islamabad, Pakistan

Faizan Yasin

Department of Medicine, Shifa Tameer-e-Millat University

Ahmed H. Qavi, M.D.

Department of Medicine, Mahroof Hospital