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Original article
peer-reviewed

Reference Data for Standardized Quality of Life Questionnaires in Indian Patients with Brain Metastases from Non-small Cell Lung Cancer: Results from a Prospective Study



Abstract

Introduction

Reference data for European Organization for Research and Treatment of Cancer (EORTC) quality of life questionnaires do not include studies from the Indian subcontinent. The objective of the current study was to establish a reference dataset for Indian patients of non-small cell lung cancer (NSCLC) presenting with brain metastases (BM).

Material and methods

One hundred forty patients with NSCLC with BM treated between 2012-2015 were registered in a prospective cohort study (CTRI/2013/01/003299). The baseline quality of life was evaluated using the EORTC general quality of life questionnaire QLQ-C30 and lung cancer specific module LC13. Minimum important difference (MID) scores for individual domains of the EORTC QLQ-C30 and LC13 questionnaires were derived (MID = 0.2 x standard deviation) from the reference data for patients with recurrent/metastatic lung cancers. In addition, a systematic review was conducted to identify studies reporting baseline quality of life scores for recurrent/metastatic NSCLC.

Results

Scores of several functional as well as symptom scales in the current NSCLC population differed by more than the MID from the baseline mean scores in the reference EORTC population as well as that reported from other studies. Differences in mean score from the EORTC reference data ranged from 6.2 and 9.4 points for the role functioning and cognitive functioning domains. In the symptom scales, the largest differences were observed for the financial difficulties (23.9) scores for the QLQ-C30 and peripheral neuropathy (21.7) for LC13 questionnaires.

Conclusion

The current study demonstrates that baseline reference scores need to be established for patients from the Indian subcontinent. The findings from the current study have important implications for studies employing quality of life (QOL) assessment in the Indian NSCLC patient population.



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Original article
peer-reviewed

Reference Data for Standardized Quality of Life Questionnaires in Indian Patients with Brain Metastases from Non-small Cell Lung Cancer: Results from a Prospective Study


Author Information

Jaiprakash Aggarwal

Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India

Santam Chakraborty Corresponding Author

Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India

Sarbani Ghosh Laskar

Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India

Vijay M. Patil

Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India

Kumar Prabhash

Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India

Atanu Bhattacharya

Department of Biostatistics, Malabar Cancer Center

Vanita Noronha

Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India

Nilendu C. Purandare

Department of Nuclear Medicine, Tata Memorial Hospital, Mumbai, India

Amit Joshi

Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India

Naveen Mummudi

Radiation Oncology, Tata Memorial Hospital, Mumbai, India

Department of Radiation Oncology, Christian Medical College Hospital, Vellore, India

Jitendra Arora

Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India

Rupali Badhe

Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India


Ethics Statement and Conflict of Interest Disclosures

Human subjects: Consent was obtained by all participants in this study. Tata Memorial Hospital IRB issued approval 1060. Written informed consent was obtained from all patients prior to inclusion in the study. No identifying information has been used in the paper and all data has been deanonymized. The research was conducted in accordance with the Helsinki Declaration. Animal subjects: This study did not involve animal subjects or tissue. Conflicts of interest: The authors have declared that no conflicts of interest exist.

Acknowledgements

We gratefully acknowledge the intramural grant provided by Tata Memorial Center for the study.


Original article
peer-reviewed

Reference Data for Standardized Quality of Life Questionnaires in Indian Patients with Brain Metastases from Non-small Cell Lung Cancer: Results from a Prospective Study


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Original article
peer-reviewed

Reference Data for Standardized Quality of Life Questionnaires in Indian Patients with Brain Metastases from Non-small Cell Lung Cancer: Results from a Prospective Study

  • Author Information
    Jaiprakash Aggarwal

    Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India

    Santam Chakraborty Corresponding Author

    Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India

    Sarbani Ghosh Laskar

    Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India

    Vijay M. Patil

    Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India

    Kumar Prabhash

    Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India

    Atanu Bhattacharya

    Department of Biostatistics, Malabar Cancer Center

    Vanita Noronha

    Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India

    Nilendu C. Purandare

    Department of Nuclear Medicine, Tata Memorial Hospital, Mumbai, India

    Amit Joshi

    Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India

    Naveen Mummudi

    Radiation Oncology, Tata Memorial Hospital, Mumbai, India

    Department of Radiation Oncology, Christian Medical College Hospital, Vellore, India

    Jitendra Arora

    Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India

    Rupali Badhe

    Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India


    Ethics Statement and Conflict of Interest Disclosures

    Human subjects: Consent was obtained by all participants in this study. Tata Memorial Hospital IRB issued approval 1060. Written informed consent was obtained from all patients prior to inclusion in the study. No identifying information has been used in the paper and all data has been deanonymized. The research was conducted in accordance with the Helsinki Declaration. Animal subjects: This study did not involve animal subjects or tissue. Conflicts of interest: The authors have declared that no conflicts of interest exist.

    Acknowledgements

    We gratefully acknowledge the intramural grant provided by Tata Memorial Center for the study.


    Article Information

    Published: April 10, 2017

    DOI

    10.7759/cureus.1149

    Cite this article as:

    Aggarwal J, Chakraborty S, Ghosh laskar S, et al. (April 10, 2017) Reference Data for Standardized Quality of Life Questionnaires in Indian Patients with Brain Metastases from Non-small Cell Lung Cancer: Results from a Prospective Study. Cureus 9(4): e1149. doi:10.7759/cureus.1149

    Publication history

    Received by Cureus: February 08, 2017
    Peer review began: February 22, 2017
    Peer review concluded: March 29, 2017
    Published: April 10, 2017

    Copyright

    © Copyright 2017
    Aggarwal et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 3.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

    License

    This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Introduction

Reference data for European Organization for Research and Treatment of Cancer (EORTC) quality of life questionnaires do not include studies from the Indian subcontinent. The objective of the current study was to establish a reference dataset for Indian patients of non-small cell lung cancer (NSCLC) presenting with brain metastases (BM).

Material and methods

One hundred forty patients with NSCLC with BM treated between 2012-2015 were registered in a prospective cohort study (CTRI/2013/01/003299). The baseline quality of life was evaluated using the EORTC general quality of life questionnaire QLQ-C30 and lung cancer specific module LC13. Minimum important difference (MID) scores for individual domains of the EORTC QLQ-C30 and LC13 questionnaires were derived (MID = 0.2 x standard deviation) from the reference data for patients with recurrent/metastatic lung cancers. In addition, a systematic review was conducted to identify studies reporting baseline quality of life scores for recurrent/metastatic NSCLC.

Results

Scores of several functional as well as symptom scales in the current NSCLC population differed by more than the MID from the baseline mean scores in the reference EORTC population as well as that reported from other studies. Differences in mean score from the EORTC reference data ranged from 6.2 and 9.4 points for the role functioning and cognitive functioning domains. In the symptom scales, the largest differences were observed for the financial difficulties (23.9) scores for the QLQ-C30 and peripheral neuropathy (21.7) for LC13 questionnaires.

Conclusion

The current study demonstrates that baseline reference scores need to be established for patients from the Indian subcontinent. The findings from the current study have important implications for studies employing quality of life (QOL) assessment in the Indian NSCLC patient population.



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Create a free account to continue reading this article.

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Jaiprakash Aggarwal

Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India

Santam Chakraborty, M.D., Assistant Professor

Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India

For correspondence:
drsantam@gmail.com

Sarbani Ghosh Laskar

Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India

Vijay M. Patil

Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India

Kumar Prabhash

Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India

Atanu Bhattacharya

Department of Biostatistics, Malabar Cancer Center

Vanita Noronha

Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India

Nilendu C. Purandare

Department of Nuclear Medicine, Tata Memorial Hospital, Mumbai, India

Amit Joshi

Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India

Naveen Mummudi, M.D., Assistant Professor

Radiation Oncology, Tata Memorial Hospital, Mumbai, India

Jitendra Arora

Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India

Rupali Badhe

Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India

Jaiprakash Aggarwal

Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India

Santam Chakraborty, M.D., Assistant Professor

Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India

For correspondence:
drsantam@gmail.com

Sarbani Ghosh Laskar

Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India

Vijay M. Patil

Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India

Kumar Prabhash

Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India

Atanu Bhattacharya

Department of Biostatistics, Malabar Cancer Center

Vanita Noronha

Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India

Nilendu C. Purandare

Department of Nuclear Medicine, Tata Memorial Hospital, Mumbai, India

Amit Joshi

Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India

Naveen Mummudi, M.D., Assistant Professor

Radiation Oncology, Tata Memorial Hospital, Mumbai, India

Jitendra Arora

Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India

Rupali Badhe

Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India