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Case report
peer-reviewed

Brugada Syndrome in a Patient with Vascular Ehlers-Danlos Syndrome: Sudden Death Risk Amplified



Abstract

The vast majority of sudden cardiac arrests occur in patients with structural heart disease and in approximately 10% of the cases, it can occur in those with structurally normal hearts. Brugada syndrome is an autosomal dominant sodium channelopathy that has been implicated in sudden deaths. Given their low prevalence, our knowledge about Brugada syndrome is still evolving. Apart from schizophrenia, there have been no reports of associated medical conditions. We recently encountered a patient with vascular Ehlers-Danlos syndrome who was also found to have Brugada syndrome. Both these conditions share some common clinical presentations including a propensity for sudden death.



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Case report
peer-reviewed

Brugada Syndrome in a Patient with Vascular Ehlers-Danlos Syndrome: Sudden Death Risk Amplified


Author Information

Jason D'Souza Corresponding Author

Internal Medicine, Florida Hospital-Orlando

Divyanshu Malhotra

Nephrology, Yale New Haven Hospital

Aditya Goud

Internal Medicine, Medstar Franklin Square Medical Center, Baltimore, MD

Chanukya Dahagam

Internal Medicine, Medstar Franklin Square Medical Center, Baltimore, MD

George Everett

Internal Medicine, Florida Hospital-Orlando


Ethics Statement and Conflict of Interest Disclosures

Human subjects: Consent was obtained by all participants in this study. Conflicts of interest: The authors have declared that no conflicts of interest exist.


Case report
peer-reviewed

Brugada Syndrome in a Patient with Vascular Ehlers-Danlos Syndrome: Sudden Death Risk Amplified


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Case report
peer-reviewed

Brugada Syndrome in a Patient with Vascular Ehlers-Danlos Syndrome: Sudden Death Risk Amplified

  • Author Information
    Jason D'Souza Corresponding Author

    Internal Medicine, Florida Hospital-Orlando

    Divyanshu Malhotra

    Nephrology, Yale New Haven Hospital

    Aditya Goud

    Internal Medicine, Medstar Franklin Square Medical Center, Baltimore, MD

    Chanukya Dahagam

    Internal Medicine, Medstar Franklin Square Medical Center, Baltimore, MD

    George Everett

    Internal Medicine, Florida Hospital-Orlando


    Ethics Statement and Conflict of Interest Disclosures

    Human subjects: Consent was obtained by all participants in this study. Conflicts of interest: The authors have declared that no conflicts of interest exist.

    Acknowledgements


    Article Information

    Published: April 19, 2017

    DOI

    10.7759/cureus.1178

    Cite this article as:

    D'souza J, Malhotra D, Goud A, et al. (April 19, 2017) Brugada Syndrome in a Patient with Vascular Ehlers-Danlos Syndrome: Sudden Death Risk Amplified. Cureus 9(4): e1178. doi:10.7759/cureus.1178

    Publication history

    Received by Cureus: January 04, 2017
    Peer review began: January 08, 2017
    Peer review concluded: April 09, 2017
    Published: April 19, 2017

    Copyright

    © Copyright 2017
    D'Souza et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 3.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

    License

    This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The vast majority of sudden cardiac arrests occur in patients with structural heart disease and in approximately 10% of the cases, it can occur in those with structurally normal hearts. Brugada syndrome is an autosomal dominant sodium channelopathy that has been implicated in sudden deaths. Given their low prevalence, our knowledge about Brugada syndrome is still evolving. Apart from schizophrenia, there have been no reports of associated medical conditions. We recently encountered a patient with vascular Ehlers-Danlos syndrome who was also found to have Brugada syndrome. Both these conditions share some common clinical presentations including a propensity for sudden death.



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Create a free account to continue reading this article.

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Jason D'Souza, M.D.

Internal Medicine, Florida Hospital-Orlando

For correspondence:
jason4j@gmail.com

Divyanshu Malhotra

Nephrology, Yale New Haven Hospital

Aditya Goud

Internal Medicine, Medstar Franklin Square Medical Center, Baltimore, MD

Chanukya Dahagam

Internal Medicine, Medstar Franklin Square Medical Center, Baltimore, MD

George Everett

Internal Medicine, Florida Hospital-Orlando

Jason D'Souza, M.D.

Internal Medicine, Florida Hospital-Orlando

For correspondence:
jason4j@gmail.com

Divyanshu Malhotra

Nephrology, Yale New Haven Hospital

Aditya Goud

Internal Medicine, Medstar Franklin Square Medical Center, Baltimore, MD

Chanukya Dahagam

Internal Medicine, Medstar Franklin Square Medical Center, Baltimore, MD

George Everett

Internal Medicine, Florida Hospital-Orlando