"Never doubt that a small group of thoughtful, committed citizens can change the world. Indeed, it is the only thing that ever has."

Margaret Mead
TO ARTICLE
METRICS

Original article
peer-reviewed

Early Antiandrogen Therapy With Dutasteride Reduces Viral Shedding, Inflammatory Responses, and Time-to-Remission in Males With COVID-19: A Randomized, Double-Blind, Placebo-Controlled Interventional Trial (EAT-DUTA AndroCoV Trial – Biochemical)

Flavio A. Cadegiani , John McCoy, Carlos Gustavo Wambier, Andy Goren

Published: February 01, 2021

DOI: 10.7759/cureus.13047

Cite this article as: Cadegiani F A, McCoy J, Gustavo Wambier C, et al. (February 01, 2021) Early Antiandrogen Therapy With Dutasteride Reduces Viral Shedding, Inflammatory Responses, and Time-to-Remission in Males With COVID-19: A Randomized, Double-Blind, Placebo-Controlled Interventional Trial (EAT-DUTA AndroCoV Trial – Biochemical). Cureus 13(2): e13047. doi:10.7759/cureus.13047

Total Article Reads

Article reads consist of online article views and PDF downloads. Cureus data is delayed by 24 hours and PMC data is delayed by approximately one month.

Total Article Reads Cureus PMC
21,822 Article Views 14,447 5,685
PDF Downloads 1,007 683
Total Article Reads Cureus PMC
21,822 Article Views 14,447 5,685
PDF Downloads 1,007 683
Total Article Reads
21,822
Cureus PMC
Article Views 14,447 5,685
PDF Downloads 1,007 683

Article Reads by Date

Hover your cursor over a specific day or month to see the corresponding online article views and PDF downloads. Cureus data is delayed by 24 hours and PMC data is delayed by approximately one month.

Cureus Article Reads

Loading...

Cumulative Cureus and PMC Article Reads

Loading...

Article Reads by Country

Hover your cursor over a country to see the number of online article views and PDF downloads from Cureus only.
Note: PMC does not share location data and not all Cureus reads are included below as location data is not available for all IP addresses.


Rank Country Views Percentage
Show all Show less

Article Reads by U.S. States

Hover your cursor over a state to see the number of online article views and PDF downloads from Cureus only.
Note: PMC does not share location data and not all Cureus reads are included below as location data is not available for all IP addresses.


Rank State Views Percentage
Show all Show less

Citations

Citation index reporting varies. Crossref citations are listed below and Google Scholar citations can be seen by clicking the corresponding button.

Google Scholar  
Crossref Citations (15)
  1. Veskovic, D., Ros, T., Icin, T., Stepanovic, K., Janjic, N., Kuljancic, D., Sedlarevic, S., & Vlahovic, D. (2022). Association of androgenetic alopecia with a more severe form of COVID-19 infection. Irish Journal of Medical Science (1971 -). https://doi.org/10.1007/s11845-022-02981-4 doi:10.1007/s11845-022-02981-4.
  2. Sari Motlagh, R., Abufaraj, M., Karakiewicz, P. I., Rajwa, P., Mori, K., Mun, D.-H., & Shariat, S. F. (2021). Association between SARS-CoV-2 infection and disease severity among prostate cancer patients on androgen deprivation therapy: a systematic review and meta-analysis. World Journal of Urology. https://doi.org/10.1007/s00345-021-03810-6 doi:10.1007/s00345-021-03810-6.
  3. Saramago, M., Costa, V. G., Souza, C. S., Bárria, C., Domingues, S., Viegas, S. C., Lousa, D., Soares, C. M., Arraiano, C. M., & Matos, R. G. (2022). The nsp15 Nuclease as a Good Target to Combat SARS-CoV-2: Mechanism of Action and Its Inactivation with FDA-Approved Drugs. Microorganisms, 10(2), 342. https://doi.org/10.3390/microorganisms10020342 doi:10.3390/microorganisms10020342.
  4. Holm, A., Møller, A., & Aabenhus, R. (2021). Management of symptomatic patients with suspected mild-moderate COVID-19 in general practice. What was published within the first year of the pandemic? A scoping review. European Journal of General Practice, 27(1), 339–345. doi:10.1080/13814788.2021.2002295.
  5. Cavanna, L., & Citterio, C. (2021). Randomised clinical trials on outpatient treatment of SARS‐COV‐2 infection: Light and shadows. International Journal of Clinical Practice, 75(12). doi:10.1111/ijcp.14896.
  6. Cadegiani, F. A., Zimerman, R. A., Fonseca, D. N., Correia, M. N., Muller, M. P., Bet, D. L., … Goren, A. (2021). Final Results of a Randomized, Placebo-Controlled, Two-Arm, Parallel Clinical Trial of Proxalutamide for Hospitalized COVID-19 Patients: A Multiregional, Joint Analysis of the Proxa-Rescue AndroCoV Trial. Cureus. doi:10.7759/cureus.20691.
  7. Kumar, N., Zuo, Y., Yalavarthi, S., Hunker, K. L., Knight, J. S., Kanthi, Y., … Ganesh, S. K. (2021). SARS-CoV-2 Spike Protein S1-Mediated Endothelial Injury and Pro-Inflammatory State Is Amplified by Dihydrotestosterone and Prevented by Mineralocorticoid Antagonism. Viruses, 13(11), 2209. doi:10.3390/v13112209.
  8. McCoy, J., Goren, A., Cadegiani, F. A., Vaño-Galván, S., Kovacevic, M., Situm, M., … Wambier, C. G. (2021). Proxalutamide Reduces the Rate of Hospitalization for COVID-19 Male Outpatients: A Randomized Double-Blinded Placebo-Controlled Trial. Frontiers in Medicine, 8. doi:10.3389/fmed.2021.668698.
  9. Cadegiani, F. A., Fonseca, D. do N., McCoy, J., Zimerman, R. A., Mirza, F. N., Correia, M. do N., … Goren, A. (2021). Efficacy of Proxalutamide (GT0918) in Hospitalized COVID-19 Patients. SSRN Electronic Journal. doi:10.2139/ssrn.3866539.
  10. Abramenko, N., Vellieux, F., Tesařová, P., Kejík, Z., Kaplánek, R., Lacina, L., … Smetana, K. (2021). Estrogen Receptor Modulators in Viral Infections Such as SARS−CoV−2: Therapeutic Consequences. International Journal of Molecular Sciences, 22(12), 6551. doi:10.3390/ijms22126551.
  11. Ghanian, S., & Wambier, C. G. (2021). Letter to the Editor re: Baldassarri et al., 2021 “Shorter androgen receptor polyQ alleles protect against life-threatening COVID-19 disease in European males.” EBioMedicine, 68, 103425. doi:10.1016/j.ebiom.2021.103425.
  12. Puig-Domingo, M., Marazuela, M., Yildiz, B. O., & Giustina, A. (2021). COVID-19 and endocrine and metabolic diseases. An updated statement from the European Society of Endocrinology. Endocrine. doi:10.1007/s12020-021-02734-w.
  13. Wambier, C. G., Mehta, N., Goren, A., & Cadegiani, F. A. (2020). COVID‐19, androgens, and androgenic alopecia. Dermatological Reviews. doi:10.1002/der2.50.
  14. MacDonald, S., & Wambier, C. G. (2021). Letter to the Editor on “COVID-19 Infection in Men on Testosterone Replacement Therapy.” The Journal of Sexual Medicine. doi:10.1016/j.jsxm.2021.03.003.
  15. Cadegiani, F., Lin, E. M., Goren, A., & Wambier, C. G. (2021). Potential risk for developing severe COVID-19 disease among anabolic steroid users. BMJ Case Reports, 14(2), e241572. doi:10.1136/bcr-2021-241572.

Article Research Metrics

We’ve partnered with Plum Analytics to track and display research metrics for each article. (All data provided by PlumX Metrics.) Click here to learn more about Plum Analytics.