Nearly four decades after the invention of the N-localizer, its origin and history remain misunderstood. Some are unaware that a third-year medical student invented this technology. The following conspectus accurately chronicles the origin of the N-localizer, presents recently discovered evidence that documents its history, and corrects misconceptions related to its origin and early history.
Introduction & Background
The N-localizer (aka N-bar) has become an important tool for image-guided stereotactic neurosurgery and radiosurgery. The N-localizer produces two circles and one ellipse in tomographic images obtained via computed tomography (CT), magnetic resonance (MR), or positron emission tomography (PET). The relative spacing between the ellipse and the two circles precisely determines the position of the tomographic section with respect to the N-localizer (Figure 1) [1-2].
Russell A. Brown invented the N-localizer in May 1978 when he was a third-year medical student and during a research elective under the supervision of James A. Nelson at the University of Utah . In August 1978, Brown designed and built the first CT-compatible stereotactic frame in order to test the concept of the N-localizer (Figure 2). This stereotactic frame was presented at a joint meeting of the Western Neurological Society and the American Academy of Neurological Surgery held in Los Angeles, California in October 1978  and at the INSERM Symposium on Stereotactic Irradiations held in Paris, France in July 1979 .
Beginning in 1979, seven different stereotactic frames incorporated the N-localizer: Brown-Roberts-Wells (BRW) , Pfizer , Todd-Wells , Reichert-Mundinger [8-9], Kelly-Goerss Compass , Leksell , and Cosman-Roberts-Wells (CRW) . Subsequently, the N-localizer achieved widespread use in image-guided stereotactic neurosurgery and radiosurgery directed by CT [13-16], MR [17-21], and PET [22-23].
The N-localizer has assisted stereotactic radiosurgery [24-26] and neurosurgery for tumor biopsy [27-28] and resection , for hematoma evacuation [30-31], for cyst and abscess aspiration [31-34], for brachytherapy [31-37], for electrode placement to manage pain  and epilepsy [31, 38-39] and to treat Parkinson tremor [40-42], and for thalamotomy, pallidotomy, and dentatomy [31,42]. The simplicity and accuracy of the N-localizer render it an important tool for modern neurosurgery .
The impact of the N-localizer on stereotactic surgery and radiosurgery may be estimated from data compiled by Linskey, who counted the types of journal articles published during the years 1966 through 2003 . Those data are summarized as follows .
Publications devoted to tumor stereotaxis were a minor fraction of all stereotactic neurosurgery publications until 1979, when the N-localizer was first described [1-2]. Beginning in 1980, the number of publications devoted to stereotactic surgery, brachytherapy or radiosurgery increased rapidly. Publications devoted to frame-based stereotactic surgery dominated until 1994, when they were overtaken by publications devoted to stereotactic radiosurgery. Publications devoted to stereotactic radiosurgery progressively increased and subsequently outnumbered publications devoted to stereotactic surgery or brachytherapy. During the three years from 2001 through 2003, publications devoted to stereotactic radiosurgery comprised roughly two-thirds of all publications devoted to cranial tumor stereotaxis.
The volume of stereotactic radiosurgery assisted by the N-localizer has continued to increase until the present day. Leksell and Lunsford affirm , "Statistics reported by about 80% of all Gamma Knife centers indicate that as of 2014, more than a million patients had undergone Gamma Knife surgery, and approximately 60,000 new patients undergo such surgery every year."
During the 38 years since the invention of the N-localizer, misconceptions have arisen concerning its origin and early history in relation to subsequent developments in image-guided stereotactic surgery. Those misconceptions have been discussed previously . The current article presents recently discovered evidence (see Figure 9 in Appendix 6) that corroborates that previous discussion.
The first misconception maintains that the Pfizer frame was the first CT-compatible stereotactic frame and that it was constructed in 1978. Kondziolka and Lunsford of the University of Pittsburgh assert this misconception, together with their failure to discuss the prior literature, in their claim , "At our center, the first CT compatible stereotactic head frame, in collaboration with industry, was constructed in 1978 and utilized in 13 patients [6, 47]. [...] During this interval, the newly redesigned Leksell CT compatible stereotactic head frame  was used for dedicated brain biopsies under the direction of its inventor, Lars Leksell. Several groups were working on devices to allow accurate CT based stereotactic surgery .”
The above assertion presents an erroneous chronology. The Pfizer frame was neither the first CT-compatible stereotactic frame (see Figure 2) nor was it constructed and used in 1978. Instead, it was constructed and used in 1979, as per Lunsford et al., who recount , "In 1979, our first efforts in image-guided stereotactic surgery attempted to adapt an early-generation Leksell frame. The metallic artifacts precluded adequate computerized tomography (CT) imaging, and we subsequently developed a CT-compatible stereotactic device (Pfizer frame [...] ) [50, 6] which was used in an initial series of 15 patients beginning in 1979." This statement is corroborated by Lunsford, Niranjan, Kassam, Khan, Amin, and Kondziolka, who state , "During the interval of 1979 to 1980, 13 stereotactic procedures were performed in a diagnostic scanner at our hospital." These two statements confirm that the Pfizer frame was constructed and used in 1979, not in 1978.
Further evidence that the Pfizer frame was constructed in 1979 is provided by Perry, Rosenbaum, Lunsford, Swink, and Zorub, who state , "The Pfizer stereotactic frame was made after attempts to modify the Leksell frame [...] proved difficult" (italics added). This evidence is corroborated by a letter from Perry to Lunsford, Rosenbaum, and Zorub  and a letter from Pfizer Medical Systems to its patent attorney . Those letters verify that as of January 15, 1979, Perry, Rosenbaum, Lunsford, and Zorub had not yet attempted any surgery using the modified early-generation Leksell frame. Hence, the Pfizer frame, which was constructed after efforts to adapt the early-generation Leksell frame had failed, was constructed in 1979.
In addition to presenting an erroneous chronology, the above assertion  of Kondziolka and Lunsford disregards the fact that the CT-guidance technologies of the Leksell frame and the Pfizer frame were derivative. For both frames, the inclusion of vertical and diagonal elements originated from Brown's prior invention and description of the N-localizer. This fact is established by the articles that introduced the Leksell  and Pfizer  frames. Both articles cited one  of Brown's seminal articles that had introduced the N-localizer one year earlier [1-2]. Although Lunsford (with and without Kondziolka) had previously cited one or the other of Brown’s seminal articles in multiple publications [6, 31, 50-51, 54-55], these coauthors cited neither seminal article in their above assertion. Instead, they cited a later article by Roberts and Brown  that was published contemporaneously with the first articles from the University of Pittsburgh [6, 47] and one year after Brown’s seminal articles had introduced the N-localizer.
The second misconception maintains that investigators from Pfizer Medical Systems and the University of Pittsburgh invented the N-localizer. This misconception is asserted by Lunsford, Niranjan, Kassam, Khan, Amin, and Kondziolka, who claim , “During the subsequent years of training, the senior author had an opportunity to work with an innovative neuroradiologist, Arthur Rosenbaum, M.D., and an engineer, John Perry, Ph.D., who then headed the imaging division of Pfizer Medical Instruments. Together, we developed an image-guided stereotactic system using the now well-known N-localizer technology. This elegant solution was proposed by Perry et al.  and Rosenbaum et al.  independently and virtually simultaneously as publications from Brown  and Roberts and Brown  of Utah."
In the above assertion, the intended antecedent of "elegant solution" could be "image-guided stereotactic system" or "N-localizer technology." Perry et al. did propose the Pfizer image-guided stereotactic system , which incorporated the N-localizer, several months after Brown et al. had proposed the Brown-Roberts-Wells (BRW) image-guided stereotactic system . However, the historical record shows that none of the above-mentioned individuals, with the exception of Brown, invented the N-localizer. Instead, Perry adopted the N-localizer after Brown had disclosed it to him. Documents that corroborate these facts have remained preserved in the archives of the U.S. Patent and Trademark Office for more than 30 years. The following discussion, which is based on those archives, recounts Perry's research related to image-guided stereotactic surgery and reveals the events that led to his adoption of the N-localizer.
Prior to the invention of the N-localizer, Lee, Villafana, and Lapayowker had reported a method for estimating the position of a tomographic section with respect to patient anatomy [56-57]. Their method involved a plate into which were milled vertical slots whose tops lay along a diagonal line (Figure 3).
Documents from the archives of the U.S. Patent and Trademark Office indicate that as of January 15, 1979, Perry, Rosenbaum, Lunsford, and Zorub had attached three slotted plates to a Leksell frame [52-53]. In principle, three slotted plates enabled the calculation of the position of a tomographic section with respect to a stereotactic frame, similar to the manner in which three N-localizers enable this calculation (Figure 2).
In practice, however, the slotted plate was susceptible to error as a result of the discrete or quantized nature of the slots. Perry observed that it was necessary to count carefully the numerous notches that were visible in the tomographic image, because any miscount would give rise to errors in the subsequent calculation of the position of the tomographic section with respect to the stereotactic frame . Moreover, the partial volume effect [58-59], which derives from the several-millimeter thickness of the tomographic section, impeded accurate counting of the notches, because any slot that passed partially into but not entirely through the tomographic section would produce an only faintly visible notch. For these reasons, the slotted plate was vulnerable to human error and hence was unsuitable for clinical use. The N-localizer avoids these quantization problems and the attendant possibility of computational errors by virtue of the continuous nature of the N-localizer's rods.
Perry's earliest description of the slotted plate, and indeed the earliest record of his involvement with image-guided stereotactic surgery, was in his letter dated January 15, 1979, and addressed to his collaborators, Lunsford, Rosenbaum, and Zorub at the University of Pittsburgh . Perry's letter describes three slotted plates attached to a stereotactic frame and provides instructions for using computer software in conjunction with those slotted plates to calculate the position of a tomographic section with respect to that stereotactic frame. Well before the date of Perry's letter, Brown had already invented the N-localizer , built the first CT-compatible stereotactic frame , and presented his results to the Western Neurological Society and the American Academy of Neurological Surgery .
On January 25, 1979, Brown spoke by phone with one of Perry's coworkers at Pfizer Medical Systems and learned that Perry's research concerned image-guided stereotactic surgery . The following day, Pfizer Medical Systems sent to its patent attorney a letter that included a photo of a Leksell frame to which three slotted plates were attached and a photo of a CT image of the Leksell frame and slotted plates . A few days later, Brown spoke by phone with Perry and disclosed the N-localizer to him . Perry et al. subsequently abandoned the slotted plate, adopted the N-localizer, and incorporated it into the Pfizer CT-compatible stereotactic frame .
Perry's earliest description of the N-localizer was in his application to the U.S. Patent and Trademark Office dated April 13, 1979 . When challenged by Brown via a Patent Interference proceeding before the U.S. Patent and Trademark Office, Perry failed to provide any evidence whatsoever of having invented the N-localizer. Moreover, Brown's invention of the N-localizer  had preceded Perry's earliest involvement with image-guided stereotactic surgery  by eight months. Consequently, Perry conceded “priority of invention” to Brown , and the U.S. Patent and Trademark Office awarded to Brown patent protection for the N-localizer and for other significant aspects of image-guided stereotactic surgery . The documents [1, 52-53, 60-62, 65] that the U.S. Patent and Trademark Office examined prior to awarding patent protection to Brown instead of Perry are a matter of public record. Those documents may be obtained from the U.S. Patent and Trademark Office by requesting a copy of the folder for Interference No. 101267. In order to facilitate access to those documents, copies are included in the Appendices to this article.
Brown invented the N-localizer and built the first CT-compatible stereotactic frame in 1978. The N-localizer has become an important tool for modern neurosurgery and has achieved widespread use in image-guided stereotactic neurosurgery and radiosurgery directed by CT, MR, and PET. Beginning in 1979, seven different stereotactic frames incorporated the N-localizer. For each frame, the inclusion of the N-localizer was derivative and originated from Brown's research.
- Brown RA: A computerized tomography-computer graphics approach to stereotaxic localization. J Neurosurg. 1979, 50:715–720. 10.3171/jns.1979.50.6.0715
- Brown RA: A stereotactic head frame for use with CT body scanners. Invest Radiol. 1979, 14:300–304. 10.1097/00004424-197907000-00006
- Brown RA, Nelson JA: Invention of the N-localizer for stereotactic neurosurgery and its use in the Brown-Roberts-Wells stereotactic frame. Neurosurgery. 2012, 70:173–176. 10.1227/NEU.0b013e318246a4f7
- Brown RA, Roberts TS: A stereotaxic frame and computer software for use with CT body scanners. Stereotactic Cerebral Irradiation: Proceedings of the INSERM Symposium on Stereotactic Irradiation. Szikla G (ed): Elsevier/North-Holland Biomedical Press, Amsterdam; 1979. 12:25–27.
- Brown RA, Roberts TS, Osborn AE: Stereotaxic frame and computer software for CT-directed neurosurgical localization. Invest Radiol. 1980, 15:308–312. 10.1097/00004424-198007000-00006
- Perry JH, Rosenbaum AE, Lunsford LD, Swink CA, Zorub DS: Computed tomography-guided stereotactic surgery: conception and development of a new stereotactic methodology. Neurosurgery. 1980, 7:376–381. 10.1097/00006123-198010000-00011
- Goerss S, Kelly PJ, Kall B, Alker GJ Jr: A computed tomographic stereotactic adaptation system. Neurosurgery. 1982, 10:375–379. 10.1097/00006123-198203000-00014
- Mundinger F: CT-stereotactic biopsy of brain tumors. Tumors of the Central Nervous System in Infancy and Childhood. Voth D, Gutjahr P, Langmaid C (ed): Springer-Verlag, New York; 1982. 1:234-246.
- Dubois PJ, Nashold BS, Perry J, et al.: CT-guided stereotaxis using a modified conventional stereotaxic frame. AJNR Am J Neuroradiol. 1982, 3:345–351.
- Kelly PJ, Earnest F 4th, Kall BA, Goerss SJ, Scheithauer B: Surgical options for patients with deep-seated brain tumors: computer-assisted stereotactic biopsy. Mayo Clin Proc. 1985, 60:223-229. 10.1016/S0025-6196(12)60314-0
- Leksell L, Leksell D, Schwebel J: Stereotaxis and nuclear magnetic resonance. J Neurol Neurosurg Psychiatry. 1985, 48:14–18. 10.1136/jnnp.48.1.14
- Couldwell WT, Apuzzo ML: Initial experience related to the use of the Cosman-Roberts-Wells stereotactic instrument. Technical note. J Neurosurg. 1990, 72:145–148. 10.3171/jns.1990.72.1.0145
- Leksell L, Jernberg B: Stereotaxis and tomography. A technical note. Acta Neurochir (Wien). 1980, 52:1–7. 10.1007/BF01400939
- Heilbrun MP, Roberts TS, Apuzzo ML, Wells TH Jr, Sabshin JK: Preliminary experience with Brown-Roberts-Wells (BRW) computerized tomography stereotaxic guidance system. J Neurosurg. 1983, 59:217–222. 10.3171/jns.1983.59.2.0217
- Thomas DG, Anderson RE, du Boulay GH: CT-guided stereotactic neurosurgery: experience in 24 cases with a new stereotactic system. J Neurol Neurosurg Psychiatry. 1984, 47:9–16. 10.1136/jnnp.47.1.9
- Pell MF, Thomas DG: The initial experience with the Cosman-Roberts-Wells stereotactic system. Br J Neurosurg. 1991, 5:123–128. 10.3109/02688699108998457
- Thomas DG, Davis CH, Ingram S, Olney JS, Bydder GM, Young IR: Stereotaxic biopsy of the brain under MR imaging control. AJNR Am J Neuroradiol. 1986, 7:161–163.
- Lunsford LD, Martinez AJ, Latchaw RE: Stereotaxic surgery with a magnetic resonance- and computerized tomography-compatible system. J Neurosurg. 1986, 64:872–878. 10.3171/jns.1986.64.6.0872
- Heilbrun MP, Sunderland PM, McDonald PR, Wells TH Jr, Cosman E, Ganz E: Brown-Roberts-Wells stereotactic frame modifications to accomplish magnetic resonance imaging guidance in three planes. Appl Neurophysiol. 1987, 50:143–152. 10.1159/000100700
- Andoh K, Nakamae H, Ohkoshi T, Odagiri K, Kyuma Y, Hayashi A: Technical note: enhanced MR-guided stereotaxic brain surgery with the patient under general anesthesia. AJNR Am J Neuroradiol. 1991, 12:135–138.
- Kondziolka D, Dempsey PK, Lunsford LD, et al.: A comparison between magnetic resonance imaging and computed tomography for stereotactic coordinate determination. Neurosurgery. 1992, 30:402–406. 10.1227/00006123-199203000-00015
- Maciunas RJ, Kessler RM, Maurer C, Mandava V, Watt G, Smith G: Positron emission tomography imaging-directed stereotactic neurosurgery. Stereotact Funct Neurosurg. 1992, 58:134–140. 10.1159/000098986
- Levivier M, Massager N, Wikler D, et al.: Use of stereotactic PET images in dosimetry planning of radiosurgery for brain tumors: clinical experience and proposed classification. J Nucl Med. 2004, 45:1146–1154.
- Leksell L: Stereotactic radiosurgery. J Neurol Neurosurg Psychiatry. 1983, 46:797–803. 10.1136/jnnp.46.9.797
- Loeffler JS, Alexander E 3rd, Siddon RL, Saunders WM, Coleman CN, Winston KR: Stereotactic radiosurgery for intracranial arteriovenous malformations using a standard linear accelerator. Int J Radiat Oncol Biol Phys. 1989, 17:673–677. 10.1016/0360-3016(89)90123-5
- Liang JA, Lin FJ, Tsai MD, Tu CP, Hsiao AC: Implementation of stereotactic focal radiotherapy for intracranial arteriovenous malformations using a linear accelerator. J Formos Med Assoc. 1993, 92:988–994.
- Bullard DE, Nashold BS Jr, Osborn D, Burger PC, Dubois P: CT-guided stereotactic biopsies using a modified frame and Gildenberg techniques. J Neurol Neurosurg Psychiatry. 1984, 47:590–595. 10.1136/jnnp.47.6.590
- Debaene A, Gomez A, Lavieille J, Alessandri C, Legre J: Stereotactic CT localization and biopsy of brain tumours using the Leksell frame. A study of 45 cases. J Neuroradiol. 1988, 15:266–275.
- Alker G, Kelly PJ, Kall B, Goerss S: Stereotaxic laser ablation of intracranial lesions. AJNR Am J Neuroradiol. 1983, 4:727–730.
- Pell MF, Thomas DG, Krateminos GP: Stereotactic management of intrinsic brain stem lesions. Ann Acad Med Singapore. 1993, 22:447–451.
- Lunsford LD, Niranjan A, Khan AA, Kondziolka D: Establishing a benchmark for complications using frame-based stereotactic surgery. Stereotact Funct Neurosurg. 2008, 86:278–287. 10.1159/000147636
- Apuzzo ML, Chandrasoma PT, Zelman V, Giannotta SL, Weiss MH: Computed tomographic guidance stereotaxis in the management of lesions of the third ventricular region. Neurosurgery. 1984, 15:502–508. 10.1227/00006123-198410000-00005
- Apuzzo ML, Sabshin JK: Computed tomographic guidance stereotaxis in the management of intracranial mass lesions. Neurosurgery. 1983, 12:277–285. 10.1227/00006123-198303000-00005
- Apuzzo ML, Chandrasoma PT, Cohen D, Zee CS, Zelman V: Computed imaging stereotaxy: experience and perspective related to 500 procedures applied to brain masses. Neurosurgery. 1987, 20:930–937. 10.1227/00006123-198706000-00019
- Apuzzo ML, Petrovich Z, Luxton G, Jepson JH, Cohen D, Breeze RE: Interstitial radiobrachytherapy of malignant cerebral neoplasms: rationale, methodology, prospects. Neurol Res. 1987, 9:91–100.
- Sofat A, Hughes S, Briggs J, Beaney RP, Thomas DG: Stereotactic brachytherapy for malignant glioma using a relocatable frame. Br J Neurosurg. 1992, 6:543–548. 10.3109/02688699209002371
- Matsumoto K, Higashi H, Tomita S, Ohmoto T: Pineal region tumours treated with interstitial brachytherapy with low activity sources (192-iridium). Acta Neurochir (Wien). 1995, 136:21–28. 10.1007/BF01411431
- Pillay PK, Barnett G, Awad I: MRI-guided stereotactic placement of depth electrodes in temporal lobe epilepsy. Br J Neurosurg. 1992, 6:47–53. 10.3109/02688699209002901
- Kratimenos GP, Thomas DG, Shorvon SD, Fish DR: Stereotactic insertion of intracerebral electrodes in the investigation of epilepsy. Br J Neurosurg. 1993, 7:45–52. 10.3109/02688699308995055
- Dormont D, Cornu P, Pidoux B, et al.: Chronic thalamic stimulation with three-dimensional MR stereotactic guidance. AJNR Am J Neuroradiol. 1997, 18:1093–1107.
- Liu HG, Zhang K, Yang AC, Zhang JG: Deep brain stimulation of the subthalamic and pedunculopontine nucleus in a patient with Parkinson's disease. J Korean Neurosurg Soc. 2015, 57:303-306. 10.3340/jkns.2015.57.4.303
- Martinez R, Vaquero J: Image-directed functional neurosurgery with the Cosman-Roberts-Wells stereotactic instrument. Acta Neurochir (Wein). 1991, 113:176–179. 10.1007/BF01403204
- Linskey ME: The changing role of stereotaxis in surgical neuro-oncology. J Neurooncol. 2004, 69:35-54. 10.1023/B:NEON.0000041870.31126.2f
- Leksell D, Lunsford LD: The origins and birth of the Leksell Gamma Knife. Intracranial Stereotactic Radiosurgery, 2nd Edition. Lunsford LD, Sheehan JP (ed): Thieme Medical Publishers, Inc., New York; 2015. 1:1-10.
- Brown RA, Nelson JA: The Origin and History of the N-Localizer for Stereotactic Neurosurgery. Cureus. 2015, 7:e323. Accessed: September 14, 2015: http://www.cureus.com/articles/3144-the-origin-and-history-of-the-n-localizer-for-stereotactic-neurosurgery. 10.7759/cureus.323
- Kondziolka DS, Lunsford LD: CT in image guided surgery. Textbook of Stereotactic and Functional Neurosurgery, 2nd Edition. Lozano AM, Gildenberg PL, Tasker RR (ed): Springer Verlag, Berlin; 2009. 1:619–629. 10.1007/978-3-540-69960-6_40
- Rosenbaum AE, Lunsford LD, Perry JH: Computerized tomography guided stereotaxis: A new approach. Appl Neurophysiol. 1980, 43:172–173. 10.1159/000102252
- Roberts TS, Brown R: Technical and clinical aspects of CT-directed stereotaxis. Appl Neurophysiol. 1980, 43:170–171. 10.1159/000102251
- Lunsford LD, Coffey RJ, Cojocaru T, Leksell D: Image-guided stereotactic surgery: a 10-year evolutionary experience. Stereotact Funct Neurosurg. 1990, 54:375–387. 10.1159/000100239
- Lunsford LD, Rosenbaum AE, Perry J: Stereotactic surgery using the “therapeutic” CT scanner. Surg Neurol. 1982, 18:116–122. 10.1016/0090-3019(82)90369-X
- Lunsford LD, Niranjan A, Kassam A, Khan A, Amin D, Kondziolka D: Intraoperative imaging: evolutions, options, and practical applications. Clin Neurosurg. 2008, 55:76–86.
- Perry JH: Letter to Lunsford D, Rosenbaum A, and Zorub D. Available in Appendix 1 and U.S. Patent and Trademark Office Patent Interference folder 101267. 1979, 1–3.
- Matthews RS: Letter to Nixon LS. Available in Appendix 2 and U.S. Patent and Trademark Office Patent Interference folder 101267. 1979, 1–7.
- Lunsford LD: A dedicated CT system for the stereotactic operating room. Appl Neurophysiol. 1982, 45:374–378. 10.1159/000101625
- Lunsford LD, Leksell L, Jernberg B: Probe holder for stereotactic surgery in the CT scanner: a technical note. Acta Neurochir (Wien). 1983, 69:297–304. 10.1007/BF01401817
- Lee SH, Villafana T, Lapayowker MS: CT intracranial localization with a new marker system. Neuroradiology. 1978, 16:570–571. 10.1007/BF00395364
- Villafana T, Lee SH, Lapayowker MS: A device to indicate anatomical level in computed tomography. J Comput Assist Tomogr. 1978, 2:368–371. 10.1097/00004728-197807000-00028
- Dohrmann GJ, Geehr RB, Robinson F, Allen WE 3rd, Orphanoudakis, SC: Small hemorrhages vs. small calcifications in brain tumors: difficulty in differentiation by computed tomography. Surg Neurol. 1978, 10:309–312.
- Schultz E, Felix R: Phantom measurements of spatial resolution and the partial-volume-effect in computer tomography (article in German). Rofo. 1978, 129:673–678. 10.1055/s-0029-1231185
- Brown RA: Notebook 1. Available in Appendix 3 and U.S. Patent and Trademark Office Patent Interference folder 101267. 1978, 26–30.
- Brown RA: Notebook 1. Available in Appendix 4 and U.S. Patent and Trademark Office Patent Interference folder 101267. 1978, 80–83.
- Brown RA: Notebook 2. Available in Appendix 5 and U.S. Patent and Trademark Office Patent Interference folder 101267. 1979, 54.
- Perry JH: Letter to McIff EB. Available in Appendix 6. 1979, 1.
- Perry JH: Stereotactic surgery apparatus and method. U.S. patent 4341220. 1982, 1–10.
- Perry JH: Concession of Priority. Available in Appendix 7 and U.S. Patent and Trademark Office Patent Interference folder 101267. 1985, 1.
- Brown RA: System using computed tomography as for selective body treatment. U.S. patent 4608977. 1986, 1–12.
The Invention and Early History of the N-Localizer for Stereotactic Neurosurgery
Ethics Statement and Conflict of Interest Disclosures
Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.
The authors thank Barbara Pedrick for assistance in obtaining copies of journal articles.
Cite this article as:
Brown R A, Nelson J A (June 14, 2016) The Invention and Early History of the N-Localizer for Stereotactic Neurosurgery. Cureus 8(6): e642. doi:10.7759/cureus.642
Received by Cureus: May 25, 2016
Peer review began: May 27, 2016
Peer review concluded: June 23, 2016
Published: June 14, 2016
© Copyright 2016
Brown et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 3.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.