"Never doubt that a small group of thoughtful, committed citizens can change the world. Indeed, it is the only thing that ever has."

Margaret Mead
Review article

IgG4-Related Hypophysitis: Case Report and Literature Review


IgG4-related hypophysitis is a rare, inflammatory process of the pituitary that mimics more commonly seen pituitary tumors. We report a case of IgG4-related hypophysitis in a 16-year-old female with diabetes insipidus who was found to have IgG4-related hypophysitis based on tissue diagnosis. This entity has not been previously described in a pediatric patient. Recognition of certain inflammatory processes of the pituitary may lead to alternative means of diagnosis and medical management without a biopsy.

Introduction & Background

IgG4-related disease (IgG4-RD) is a rare, newly recognized, multi-organ disease characterized by a tendency to form tumefactive lesions in multiple sites throughout the body. Pituitary involvement, IgG4 hypophysitis, is less commonly reported and, when described, is usually associated with IgG4-RD elsewhere in the body. In this case report, we present a pediatric patient who presented with diabetes insipidus and an isolated suprasellar mass which was subsequently resected revealing a pathologic diagnosis of IgG4 hypophysitis. This is the first report of IgG4 hypophysitis in a pediatric patient. Given that the treatment of IgG4 hypophysitis is drastically different than treatment for other more common pituitary tumors within this population, it is important to consider this entity in the differential in order to prevent unnecessary invasive procedures and subsequent morbidity.

Case report

A 16-year-old female presented to our endocrinology, otolaryngology, and neurosurgery clinics for an evaluation of a suprasellar lesion. She had presented three months previous to an outside endocrinologist for excessive polyuria and polydipsia. She was found to have a serum osmolality of 292 mOsm/kg and a urine osmolality of 50 mOsm/kg, and was given a diagnosis of diabetes insipidus. During the workup, magnetic resonance imaging revealed a 2 cm peripherally enhancing, partially cystic sellar/suprasellar mass causing compression of the optic chiasm (Figure 1).

She was referred to our institution for definitive treatment of what was thought to be most likely a craniopharyngioma. The patient agreed to participate and was explained the nature and objectives of this study, and informed consent was obtained. No reference to the patient's identity was made at any stage during data analysis or in the report.

When she presented at our institution, she had previously been placed on DDAVP 0.05 mg twice a day, which had largely resolved her previous symptoms although she did complain of occasional headaches. There were no visual changes, sicca symptoms, rashes, vocal changes, smell or taste changes, amenorrhea, galactorrhea, Raynaud’s, or photosensitivity. Her past medical history was significant for atopic dermatitis controlled with steroid creams and right hearing loss since age five. On examination, her visual fields and acuity were intact, and neurological examination was unremarkable. There was no corneal dryness or ulceration, and the oral mucosa showed adequate saliva pool and no sores. Parotid glands were not tender or enlarged, and the thyroid gland was not palpable.

Laboratory testing showed free T3, T4, thyroid-stimulating hormone, and a random serum cortisol were all within normal limits. Serum prolactin and growth hormone levels were normal. Follicle-stimulating hormone and luteinizing hormone were appropriate. Urine specific gravity was normal as well.

Computed tomography performed at our institution showed a low attenuating sellar/suprasellar lesion similar to what was seen with MRI imaging at the outside institution. No calcifications were appreciated. No cavernous sinus involvement was found. Scattered white matter abnormalities were present though stable and thought to be unrelated to the pituitary findings.

Based on imaging and presentation, the differential included a craniopharyngioma, hypophysitis, and less likely a pituitary adenoma. Clinical signs and symptoms suggestive of granulomatosis with polyangiitis (GPA) (Wegener's) were not present. Because of the possibility of mass effect on the optic chiasm and radiologic findings consistent with craniopharyngioma, namely the solid/cystic appearance and the peripheral enhancement of the lesion, an endoscopic transsphenoidal resection of the pituitary was performed. The lesion was found to be encapsulated and consisted of a white-tan diffluent material. The lesion was completely resected from the sella and sent, in aggregate, for pathologic evaluation.

Sections of the lesion showed extensive infiltration of mature plasma cells intermixed with lymphocytes (Figure 2). Sections were immunostained for both IgG4 and IgG, and the calculated ratio approximated 25%. However, the 50 plasma cells/high-power field meets consensus criteria for diagnosis of the plasmacytic hypophysitis even in the absence of a ratio exceeding 40% IgG4/IgG or (storiform) fibrosis. The plasma cells numbered over 50 per high-powered field. By kappa and lambda in-situ hybridization, the plasma cells were polytypic, ruling out a clonal process. No significant fibrosis was noted. These findings were considered consistent with a diagnosis of IgG4 hypophysitis.

Postoperatively, the patient experienced a small CSF fluid leak which was repaired surgically without issue. She was discharged from the hospital on steroid replacement and DDAVP. Given the diagnosis, the patient was referred to Rheumatology for follow-up. She was found to have no obvious sign or symptoms of systemic involvement of IgG4-RD. An IgG4 level was performed and was normal; however, the patient was receiving chronic steroid replacement therapy at that time. Unfortunately, there have been no follow-up visits at our institution since that time.


IgG4-related disease (IgG4-RD) is a newly recognized, fibroinflammatory disease that has been shown to affect almost every organ of the body, with preference for the pancreas, salivary gland, orbital tissue, lymph node, lung, and kidney. It is characterized by tumorous swelling of affected organs, prominent lymphoplasmacytic infiltrate rich in IgG4-positive plasma cells, and high serum IgG4 concentrations. IgG4-RD can also cause diffuse infiltrative lesions presenting without constitutional symptoms, which usually makes the diagnosis incidental and based upon radiographic findings or examination of pathological specimens. Spontaneous improvement is very rare, and the majority of cases show slow and indolent progression. IgG4-RD affects mostly middle-aged and elderly men, but the male-female ratio is balanced in patients with predominantly head and neck involvement. It is important to differentiate IgG4-RD from malignancies with mass-forming lesions and some immune-mediated diseases (e.g.Churg-Strauss syndrome, multicentric Castleman’s disease, sarcoidosis, Sjogren’s syndrome) by additional histopathological examination. Granulomatosis with polyangiitis (GPA) (Wegener's) may mimic IgG4-related disease and is an important consideration in the differential diagnosis [1-3]. The pathogenesis of IgG4-RD is unknown but is likely related to autoimmunity or chronic infection [4]. At this time, elevated serum IgG4 or IgG4-IgG ratio is found in up to 70% of patients with IgG4-RD, but data regarding the use of their serial measurements as disease activity markers are uncertain [5]. So far, there is no evidence to suggest that the IgG4 autoantibodies are directly pathogenic in IgG4-RD. This is in sharp contrast with certain immune-mediated conditions (pemphigus vulgaris and foliaceus, thrombotic thrombocytopenic purpura, and some cases of childhood membranous glomerulonephritis) in which autoreactive IgG4 autoantibodies induce direct damage by binding their cognate antigens [6].

The recognition of IgG4-RD involvement of the pituitary created a new category within the broad term of hypophysitis, which is used to describe inflammatory disorders of the pituitary.  Within this spectrum, many types of hypophysitis have been identified including two more common forms (lymphocytic/autoimmune and granulomatous) and several more rare forms (xanthomatous, necrotizing, and plasmacytic/IgG4-related). Interestingly, while lymphocytic hypophysitis is also pathologically characterized by a lymphoplasmacytic infiltrate, there is a predominance of lymphocytes (B and T cells) rather than plasma cells [7]. Additionally, the demographics of the two diseases are very different--lymphocytic hypophysitis being described in young adult females (mean age at presentation 38 years; female to male ratio of 3:1) and IgG4-related occurring in older males [8]. It is not certain whether these entities are distinct or lie on the same histopathologic spectrum without specific assessment of IgG4 levels on serology or immunohistochemistry. Intracranial IgG4-RD presents as pachymeningitis or hypophysitis and generally does not affect the brain parenchyma. When the pituitary gland or stalk is affected, the most commonly reported outcomes include hypopituitarism, diabetes insipidus, or local mass effect [9].

A review of the 18 reported case reports of IgG4-related hypophysitis [8, 10-24] shows that all but one patient presented with a form of hypopituitarism, including central diabetes insipidus, hypogonadism, hypothyroidism, and hypocortisolism (Table 1). Many patients also had symptoms related to mass effect.

  Study   Age, Gender, Race Clinical Symptoms Laboratory CNS Imaging (modality) Biopsy Source Other Organ Involvement Treatment, Response
Van der Vliet et al., 2004 [10] 66, F, not reported Nausea, headache, swollen salivary gland Hypothyroidism, increased serum IgG4 Sellar mass (CT) Submandibular mass Present Prednisone, marked
Yamamoto et al., 2006 [11] 70, M, Japanese Swollen salivary glands, sexual dysfunction Hypogonadism, increased IgG4 Enlarged pituitary stalk (MRI) Submandibular mass Present Prednisolone; marked
Tanabe et al., 2006 [12] 71, M, Japanese Fatigue, weight loss, polydipsia, swollen salivary glands Panhypopituitarism, increased IgG4 Swelling of pituitary (MRI) Salivary gland and retroperitoneal mass Present Hydrocortisone, marked
Ralli et al., 2007 [13] 67, M, not reported Generalized weakness Panhypopituitarism, increased IgG4 Enlarged stalk and pituitary (MRI) Pancreas Present Prednisone, marked
Wong et al., 2007 [14] 77, M, Chinese Blurred vision Hypogonadism, increased IgG4 Pituitary mass (MRI) Pituitary, pancreas, gallbladder Present Hydrocortisone, not known
Isaka et al., 2008 [15] 55, M, Japanese Fatigue, polyuria/polydipsia, nasal discharge Diabetes insipidus (DI) Enlarged stalk (MRI); Mass in sphenoidal, maxillary, frontal sinuses (CT) Paranasal mass Present Prednisone, marked
Tsuboi et al., 2008 [16] 62, M, Japanese Fatigue, weight loss, fever Hypocortisolism, hypothyroidism, DI Enlarged stalk (MRI); Lung Present Glucocorticoid, good
Osawa et al., 2009 [17] 74, F, Japanese Fatigue, polydipsia Panhypopituitarism Swelling of pituitary (MRI) Pituitary None Glucocorticoids; marked
Hori et al., 2010 [18] 70, M, Japanese Fatigue, thirst, nausea DI, adrenal insufficiency, increased IgG4 Enlarged pituitary and stalk (MRI) Salivary gland, liver, lung Present Hydrocortisone, marked
Haraguchi et al., 2010, case 1 [19] 74, F, Japanese Fatigue, anorexia, polyuria, polydipsia Panhypopituitarism, DI, increased IgG4 Swelling of pituitary and stalk (MRI) None None Prednisone, marked
Haraguchi et al., 2010, case 2 [19] 68, M, Japanese Polyuria, polydipsia DI Enlargement of stalk (MRI) Retroperitoneal Present Prednisolone, good
Leporati et al., 2011 [8] 75, M, Caucasian Headache Panhypopituitarism Enlarged pituitary, sphenoid sinus mass (MRI) Pituitary Present Prednisolone, good
Patel et al., 2011 [20] 55, M, Native American Weight loss, fever, headache, fatigue, polyuria, diplopia Panhypopituitarism, increased IgG4 Enlarged pituitary (MRI) Kidney, retroperitoneal, lymph nodes, lacrimal gland Present Prednisone, marked
Hsing et al., 2013 [21] 66, M, Chinese Weight loss, nausea, vomiting Hypogonadism, hypoadrenalism Sellar mass (MRI) Posterior mediastinal mass, pituitary mass Present Prednisolone, good
Hattori et al., 2013 [22] 55, M, Japanese Bitemporal hemianopsia Increased IgG4 Enlarged pituitary gland (unknown) Pituitary None Prednisolone, good
Caputo et al., 2014 [23] 40, M, Vietnamese Lethargy, polyuria, polydipsia Panhypopituitarism, DI Pituitary lesion (MRI) Lacrimal gland, pituitary Present Prednisolone, incomplete; azathioprine, good
Kanoke et al., 2013, case 1 [24] 53, F, not reported Headache Hyperprolactinemia Pituitary mass (MRI) Pituitary with dura Present Hydrocortsone, good
Kanoke et al., 2013, case 2 [24] 27, F, not reported Hx of germinoma, headache and fatiguability Panhypopituitarism and hypothyroidism Sellar lesion (MRI) Pituitary with dura None Hydrocortisone, unknown
Present case 16, F, unknown Polyuria, polydipsia DI Sellar mass (MRI) Pituitary None Hydrocortisone unknown

Demographic details of the 18 reported cases demonstrated a mean age of 62.5 years (range 27-77) and a male predominance 13/18 (72%). The majority of the cases have been described in patients of Asian descent; however, this may be reflective of the increased awareness of IgG4-RD within the community. Each of these cases had other organ manifestations either synchronously or metachronously except two cases having hypophysitis as the sole manifestation in a 74-year-old female [17] and 55-year-old male [22]. This allowed for some diagnoses to be made based on biopsies performed on areas that were more easily accessible and less invasive, such as the salivary gland, with concurrent imaging and serum IgG4 levels. Only a minority of the patients required a pituitary biopsy for definitive diagnosis. Once diagnosed, all patients were treated with steroids with or without hormone replacement therapy depending on their initial presentation. All patients showed clinical improvement after the start of steroid therapy, some with a complete resolution of symptoms. Several patients continued to need hormone replacement therapy after the resolution of their hypophysitis suggesting damage to the pituitary may be permanent in some cases.

Diagnosis of IgG4-related hypophysitis can be made a variety of ways. Pituitary biopsy is the most definitive; however, a biopsy can be invasive and unnecessary in certain cases. Diagnosis of IgG4-related hypophysitis can also be suggested based on biopsy-proven IgG4-related disease in other organs when classic imaging findings of hypophysitis are present, including homogeneously enhancing sellar mass/thickened pituitary stalk. A guideline for a histologic diagnosis of IgG4-related disease has been previously described in a consensus statement on the entity and includes a dense lymphoplasmacytic infiltrate, storiform fibrosis, obliterative phlebitis, and an increased number of plasma cells (Table 2).

Diagnostic Criteria for IgG4-Related Hypophysitis
1 Pituitary Histopathology
  Mononuclear infiltration of the pituitary gland, rich in lymphocytes and plasma cells, with more than 10 IgG-positive cells per high-power field
2 Pituitary MRI
  Sellar mass/thickened pituitary stalk
3 Biopsy-Proven Involvement in Other Organs
  Association with IgG4-positive lesions in other organs
4 Serology
  Increased serum IgG4 (>140 mg/dl)
5 Response to Glucocorticoids
  Shrinkage of the pituitary mass and symptom improvement with steroids
Diagnosis of IgG4-related hypophysitis is established when any of the following is fulfilled:
  1 2 and 3 2, 4, and 5

For some organs, obliterative phlebitis and storiform fibrosis are uncommon, and consensus histologic criteria for these features with pituitary involvement have not been described [25]. The number of plasma cells per high-power field suggested as an appropriate cutoff varies per author but ranges from 10 to 50, with 50 plasma cells per high-power field being highly specific. A secondary diagnostic tool is the IgG4+ to total IgG+ plasma cell ratio, with over 40% as a proposed cutoff value [25]. If no biopsies are available, a third option for diagnosis includes classic imaging, increased serum IgG4 levels (>140 mg/dl), and a good response to glucocorticoids as seen by symptom improvement and shrinkage of the pituitary lesion.

While there is no standardized regimen for steroid therapy for this disease, a dose of 0.6 mg/kg/day of prednisolone is most often used. This should be continued for 1-2 months, with a taper of 5 mg per week. If relapse should occur, the physician may consider a maintenance dose for an extended period of time, up to three years, or a combination of immunosuppressants [26-27].

The present case differs from the reported cases of IgG4-related hypophysitis in several important aspects. The first aspect which makes this case interesting is the lack of convincing systemic features. Most patients with this disease have concurrent or previous involvement of other organs. Her lack of systemic involvement made it difficult to diagnose hypophysitis without tissue examination. Imaging studies were also misleading in this patient, with features suggestive of a neoplastic process, particularly solid and cystic components that would be most commonly seen in craniopharyngioma.

Another unusual aspect is the age of the patient. There have been no reported cases of IgG4-related hypophysitis in a patient less than 27 years old. While rare, IgG4-RD has been described in the pediatric population, usually within the context of autoimmune pancreatitis. Often these patients have additional systemic manifestations including retroperitoneal fibrosis, sialadenitis, and mediastinal adenopathy [28]. It is likely that other cases of IgG4-related hypophysitis have occurred in this age group and have been reported as different entities, or that treatment of co-existing systemic symptoms effectively treated the hypophysitis. The most recent cases described by Kanoke et al., illustrate this point--two adult patients were diagnosed as autoimmune hypophysitis (case 1) and granulomatous hypophysitis (case 2), but met histologic criteria for IgG4-related hypophysitis with increased IgG4+ and IgG ratios of 50% and 40%, respectively [24]. Recent literature has suggested that not infrequently there are cases of hypophysitis with IgG4 plasma cells that are not part of the systemic syndrome [29].


IgG4-related hypophysitis is a rare condition not previously reported in a pediatric age group. The clinical presentation is similar to that for other inflammatory conditions of the pituitary. The decision to biopsy a pituitary mass in the teenage population is often straight forward for cases of a tumor; however, inflammatory processes which create a mass effect can sometimes be treated without a biopsy. This relies on the physician’s ability to recognize the possibility of rare, inflammatory processes such as IgG4 hypophysitis and having a knowledge of alternative ways to confirm the diagnosis. Avoiding a biopsy can decrease morbidities associated with the procedure and may avoid the need for long-term hormone replacement. Because this disease process has not yet been described in the pediatric population, and due to lack of systemic organ involvement or serum IgG4 levels to indicate a possible IgG4-related disease process, a biopsy was necessary to rule out a more common pituitary tumor and to achieve the diagnosis of IgG4-related hypophysitis. Recent literature has suggested that not infrequently there are cases of hypophysitis with IgG4 plasma cells that are not part of the systemic syndrome. Although it appears likely that this patient is not at risk for further involvement of multiple sites, a definitive biopsy has allowed the patient to seek close clinical follow-up by a rheumatologist.


  1. Chang SY, Keogh KA, Lewis JE, et al.: IgG4-positive plasma cells in granulomatosis with polyangiitis (Wegener's): a clinicopathologic and immunohistochemical study on 43 granulomatosis with polyangiitis and 20 control cases. Hum Pathol. 2013, 44:2432-2437. 10.1016/j.humpath.2013.05.023
  2. Bando H, Iguchi G, Fukuoka H, et al.: A diagnostic pitfall in IgG4-related hypophysitis: infiltration of IgG4-positive cells in the pituitary of granulomatosis with polyangiitis. Pituitary. 2015, 18:722-730. 10.1007/s11102-015-0650-9
  3. Chang SY, Keogh K, Lewis JE, Ryu JH, Yi ES: Increased IgG4-positive plasma cells in granulomatosis with polyangiitis: a diagnostic pitfall of IgG4-related disease. Int J Rheumatol. 2012, 2012:121702. 10.1155/2012/121702
  4. Zen Y, Nakanuma Y: Pathogenesis of IgG4-related disease. Curr Opin Rheumatol. 2011, 23:114–118. 10.1097/BOR.0b013e3283412f4a
  5. Sah RP, Chari ST: Serologic issues in IgG4-related systemic disease and autoimmune pancreatitis. Curr Opin Rheumatol. 2011, 23:108–113. 10.1097/BOR.0b013e3283413469
  6. Divatia M, Kim SA, Ro JY: IgG4-related sclerosing disease, an emerging entity: a review of a multi-system disease. Yonsei Med J. 2012, 53:15–34. 10.3349/ymj.2012.53.1.15
  7. Fehn M, Sommer C, Ludecke DK, Plöckinger U, Saeger W: Lymphocytic hypophysitis: Light and electron microscopic findings and correlation to clinical appearance. Endocr Pathol. 1998, 9:71–78. 10.1007/BF02739954
  8. Leporati P, Landek-Salgado MA, Lupi I, Chiovato L, Caturegli P: IgG4-related hypophysitis: a new addition to the hypophysitis spectrum. J Clin Endocrinol Metab. 2011, 96:1971–1980. 10.1210/jc.2010-2970
  9. Mahajan VS, Mattoo H, Deshpande V, Pillai SS, Stone JH: IgG4-related disease. Annu Rev Pathol. 2014, 9:315-347. 10.1146/annurev-pathol-012513-104708
  10. van der Vliet HJ, Perenboom RM: Multiple pseudotumors in igG4-associated multifocal systemic fibrosis. Ann Intern Med. 2004, 141:896–897. 10.7326/0003-4819-141-11-200412070-00033
  11. Yamamoto M, Takahashi H, Ohara M, et al.: A case of Mikulicz's disease (IgG4-related plasmacytic disease) complicated by autoimmune hypophysitis. Scand J Rheumatol. 2006, 35:410–411. 10.1080/03009740600758110
  12. Tanabe T, Tsushima K, Yasuo M, et al.: IgG4-associated multifocal systemic fibrosis complicating sclerosing sialadenitis, hypophysitis, and retroperitoneal fibrosis, but lacking pancreatic involvement. Intern Med. 2006, 45:1243–1247.
  13. Ralli S, Lin J, Farrell J: Autoimmune pancreatitis. N Engl J Med. 2007, 356:1586-1587. 10.1056/NEJMc070069
  14. Wong S, Lam WY, Wong WK, Lee KC: Hypophysitis presented as inflammatory pseudotumor in immunoglobulin G4-related systemic disease. Hum Pathol. 2007, 38:1720-1723. 10.1016/j.humpath.2007.06.011
  15. Isaka Y, Yoshioka K, Nishio M, et al.: A case of IgG4-related multifocal fibrosclerosis complicated by central diabetes insipidus. Endocr J. 2008, 55:723–728. 10.1507/endocrj.K08E-034
  16. Tsuboi H, Inokuma S, Setoguchi K, et al.: Inflammatory pseudotumors in multiple organs associated with elevated serum IgG4 level: recovery by only a small replacement dose of steroid. Intern Med. 2008, 47:1139–1142. 10.2169/internalmedicine.47.0887
  17. Osawa S, Ogawa Y, Watanabe M, Tominaga T: Hypophysitis presenting with atypical rapid deterioration: with special reference to immunoglobulin G4-related disease -case report-. Neurol Med Chir (Tokyo). 2009, 49:622–625. 10.2176/nmc.49.622
  18. Hori M, Makita N, Andoh T, et al.: Long-term clinical course of IgG4-related systemic disease accompanied by hypophysitis. Endocr J. 2010, 57:485–492. 10.1507/endocrj.K09E-356
  19. Haraguchi A, Era A, Yasui J, et al.: Putative IgG4-related pituitary disease with hypopituitarism and/or diabetes insipidus accompanied with elevated serum levels of IgG4. Endocr J. 2010, 57:719–725. 10.1507/endocrj.K10E-030
  20. Patel SM, Szostek JH: IgG4-related systemic disease in a Native American man. Intern Med. 2011, 50:931–934. 10.2169/internalmedicine.50.4593
  21. Hsing MT, Hsu HT, Cheng CY, Chen CM: IgG4-related hypophysitis presenting as a pituitary adenoma with systemic disease. Asian J Surg. 2013, 36:93–97. 10.1016/j.asjsur.2012.04.013
  22. Hattori Y, Tahara S, Ishii Y, et al.: A case of IgG4-related hypophysitis without pituitary insufficiency. J Clin Endocrinol Metab. 2013, 98:1808-1811. 10.1210/jc.2013-1088#sthash.86hLMX5h.dpuf
  23. Caputo C, Bazargan A, McKelvie PA, Sutherland T, Su CS, Inder WJ: Hypophysitis due to IgG4-related disease responding to treatment with azathioprine: an alternative to corticosteroid therapy. Pituitary. 2014, 17:251-256. 10.1007/s11102-013-0498-9
  24. Kanoke A, Ogawa Y, Watanabe M, Kumabe T, Tominaga T: Autoimmune hypophysitis presenting with intracranial multi-organ involvement: three case reports and review of the literature. BMC Res Notes. 2013, 6:560. 10.1186/1756-0500-6-560
  25. Deshpande V, Zen Y, Chan JK, et al.: Consensus statement on the pathology of IgG4-related disease. Mod Pathol. 2012, 25:1181-1192. 10.1038/modpathol.2012.72
  26. Chari ST: Current concepts in the treatment of autoimmune pancreatitis. JOP. 2007, 8:1–3.
  27. Kamisawa T, Shimosegawa T, Okazaki K, et al.: Standard steroid treatment for autoimmune pancreatitis. Gut. 2009, 58:1504-1507. 10.1136/gut.2008.172908
  28. Mannion M, Cron RQ: Successful treatment of pediatric IgG4 related systemic disease with mycophenolate mofetil: case report and a review of the pediatric autoimmune pancreatitis literature. Pediatr Rheumatol Online J. 2011, 9:1. 10.1186/1546-0096-9-1
  29. Sosa GA, Bell S, Christiansen SB, et al.: Histologically confirmed isolated IgG4-related hypophysitis: two case reports in young women. Endocrinol Diabetes Metab Case Rep. 2014, 2014:140062. 10.1530/EDM-14-0062
Review article

IgG4-Related Hypophysitis: Case Report and Literature Review

Author Information

Lauren Decker

Pathology, University of New Mexico School of Medicine, Albuquerque, New Mexico

Angela M. Crawford

Department of Surgery, University of Maryland

Gamaliel Lorenzo

Department of Radiology, University of New Mexico School of Medicine, Albuquerque, New Mexico

Martina Stippler

Neurosurgery, Beth Israel Deaconess Medical Center

Konstantin N. Konstantinov

Internal Medicine, University of New Mexico School of Medicine, Albuquerque, USA

Karen SantaCruz Corresponding Author

Pathology, University of New Mexico School of Medicine, Albuquerque, New Mexico

Ethics Statement and Conflict of Interest Disclosures

Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Review article

IgG4-Related Hypophysitis: Case Report and Literature Review

Figures etc.


Scholary Impact Quotient™ (SIQ™) is our unique post-publication peer review rating process. Learn more here.