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Case report

Applying Telemedicine Technology in Treating Prolactinomas: A Case Report


Despite being considered a relatively new concept, telemedicine has already been associated with improved outcomes and reduced healthcare utilization in the management of several high-risk diseases. However, no reports to date have examined the effectiveness of telemedicine in managing prolactinomas. We report a case of a young male with a macroprolactinoma who was reviewed initially in a face-to-face encounter, however, continued his subsequent management virtually using telemedicine methods with satisfactory clinical outcomes.


Prolactinomas are the most common subtype of pituitary adenomas, affecting females more than males [1]. They may present with symptoms of galctorrhoea, hypogonadism (e.g. amenorrhoea) or pressure effects into nearby structures (e.g. the optic chiasm, causing visual field defects). Alternatively, prolactinomas can be detected incidentally during brain imaging. In addition, a small proportion can be detected following checks of serum prolactin level, most commonly in the general practice setting. Once identified, serum prolactin levels have to be confirmed (i.e. by excluding the presence of macroprolactin and or a falsely raised level due to the hook effect) [2]. The next investigation of choice is a dedicated pituitary MRI scan (T1 and T2 weighted scans, with or without gadolinium) [3].

Treatment goals are to resume normal gonadal function, preserve other pituitary axes and alleviate or reduce the mass-effect consequences of large adenomas on nearby structures [1]. This can be achieved by the use of dopamine agonist (DA) therapy through their inhibitory effect on the lactotroph cells. DA therapy is usually very effective and tolerated by the majority of patients [4,5]. However, a small proportion develops intolerance/side-effects or resistance to treatment [6]. This small subgroup may require other treatment modalities (e.g. surgery or radiotherapy). For the majority of patients in whom good treatment outcome (clinical, biochemical and radiological) is observed, detailed patient education on the DA side-effects and outcomes of tumour shrinkage has to take place from the first appointment.

Case Presentation

A 20-year-old man presented to our yearly outreach endocrine clinic with a one-year history of decreased libido and visual deterioration. Clinical examination showed a dense bi-temporal hemianopia (worse on the right side) which was verified by a formal perimetry assessment (Figure 1A). He had no clinical features of endocrinopathy. Initial investigations confirmed central hypogonadism, elevated serum prolactin of 57,136 mU/l (reference range = 85-304) and normal pituitary functions otherwise (Table 1). Baseline brain MRI showed a large sellar lesion compressing the optic chiasm in keeping with a pituitary macroadenoma (Figure 1B, C). The tumour extended inferiorly to reach the occipital condyles and laterally to fully invade the cavernous sinuses. A diagnosis of large invasive macroprolactinoma was made, and treatment with DA therapy (titrated dose of cabergoline) resulted in excellent tumour shrinkage within four months (Figure 1D, E). This was accompanied by a significant improvement in vision and gonadal function and a >90% reduction in serum prolactin (Figure 1F, G). CT of the skull base showed near-total invasion of the middle skull base by tumour (Figure 2). Stringent clinical, biochemical and radiological follow-up is planned. He was referred to be assessed by the clinical geneticists.

9 am test Value Reference range
Prolactin 55,136 85-304 mU/l
TSH 5.0 0.34-5.6 mU/ml
FT4 1.0 0.6-1.12 ng/dl
FT3 3.1 2.5-3.9 ng/dl
FSH 0.81 1.27-19.26 mU/ml
LH 2.91 1.1-7.0 mU/ml
Testosterone <2 13-29 nmol/l
GH 0.41 0-10 ng/ml
IGF-1 NA 11-31 nmol/l
Cortisol 304 >170 nmol/l


Our case represents one of the common scenarios in which a patient presents with visual deterioration and subsequently is discovered to have a pituitary macroadenoma. The very high level of prolactin confirms a diagnosis of macroprolactinoma and therefore the first-line treatment is DA therapy. Like many cases of macroprolactinoma, our patient responded well to treatment with excellent clinical, radiological and biochemical response (Figure 1). He showed good engagement and adherence to treatment from the first clinic visit. It was, therefore, reasonable to approach the topic of telemedicine and follow-up virtually to our patient with the knowledge that returning to face-to-face review is possible if needed.

The first clinic visit, which was conducted face-to-face, involved taking a history and performing a clinical examination, followed by discussing the disease incidence, pathophysiology, genetic predisposition, investigations, treatment options, frequency of follow up visits, and prognosis. DA side-effects and treatment outcomes, in particular consequences of rapid tumour shrinkage (e.g. CSF leak or apoplexy), were stressed upon due to the nature of his tumour (large macroadenoma invading the skull base) [7]. 3D reconstruction of the tumour and the skull-based defect helped in explaining the nature of this patient's tumour to him and aided his understanding of the possible consequences of tumour shrinkage (Figure 2). A bespoke patient leaflet was provided and all possible case scenarios of use of DA therapy in this context were explained in detail (Figure 3).


Application of teleconsultation in this case

All of his subsequent clinic consultations were performed virtually using telemedicine methods (teleconsultation using telephone and video communications, live chat using secure texting and asynchronous written advice services). He was particularly amenable to this approach because he lived in a distant rural area with poor access to specialised clinics.

The type of technology used for each consultation was tested ahead of the appointment to minimise technical failures. Video consultations were particularly helpful in allowing limited clinical examination. It also helped in facilitating complex discussions such as symptoms of hypogonadism. Real-time texting also allowed detailed data acquisition while using a simple way of communication. Written consultation (by email and by using bespoke mini questionnaires) is also time-efficient.

Proposed telemedicine approach in prolactinomas

A reasonable number of patients with prolactinoma can be managed from a distance. This method has to be applied to selected patients, regularly reviewed and with guarantees of a robust availability of local resources (Figures 4 and 5).


Standard local setup

This should constitute a named local clinician for a face-to-face review whenever needed [8,9]. A dedicated MRI scanner (preferably the same scanner) should be used for follow-up. Also, the same laboratory should be used for each repeat biochemical measurement to avoid assay variability [10]. The patient should also have a dedicated ophthalmology centre for routine and/or urgent assessments.


In conclusion, we reported a case of a macroprolactinoma in a young man which was managed using telemedicine methodology (teleconsultation) with favourable consequences. We propose the use of this approach for selected patients, with emphasis on patient empowerment, confidentiality and the swift reversal the face-to-face clinical reviews whenever needed.


  1. Melmed S, Casanueva FF, Hoffman AR, et al.: Diagnosis and treatment of hyperprolactinemia: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2011, 96:273-288. 10.1210/jc.2010-1692
  2. Chahal J, Schlechte J: Hyperprolactinemia. Pituitary. 2008, 11:141-146. 10.1007/s11102-008-0107-5
  3. Bonneville J-F: Magnetic resonance imaging of pituitary tumors. Front Horm Res. 2016, 45:97-120. 10.1159/000442327
  4. Flier JS, Underhill LH, Klibanski A, Zervas NT: Diagnosis and management of hormone-secreting pituitary adenomas. N Engl J Med. 1991, 324:822-831. 10.1056/NEJM199103213241207
  5. Varlamov E V., McCartney S, Fleseriu M: Functioning pituitary adenomas: current treatment options and emerging medical therapies. Eur Endocrinol. 2019, 15:30-40. 10.17925/EE.2019.15.1.30
  6. Pinzone JJ, Katznelson L, Danila DC, Pauler DK, Miller CS, Klibanski A: Primary medical therapy of micro- and macroprolactinomas in men. J Clin Endocrinol Metab. 2000, 85:3053-3057. 10.1210/jcem.85.9.6798
  7. Tirosh A, Shimon I: Management of macroprolactinomas. Clin Diabetes Endocrinol. 2015, 1:5. 10.1186/s40842-015-0006-4
  8. Stanberry B: Legal and ethical aspects of telemedicine. J Telemed Telecare. 2006, 12:166-175. https://doi.org/10.1258/135763306777488825
  9. Griffiths F, Watkins JA, Huxley C, et al.: Mobile consulting (mConsulting) and its potential for providing access to quality healthcare for populations living in low-resource settings of low- and middle-income countries. Digit Heal. 2020, 6:10.1177/2055207620919594
  10. Saleem M, Martin H, Coates P: Prolactin biology and laboratory measurement: an update on physiology and current analytical issues. Clin Biochem Rev. 2018, 39:3-16.
Case report

Applying Telemedicine Technology in Treating Prolactinomas: A Case Report

Author Information

Hiba Khalil

Radiology, University of Khartoum, Khartoum, SDN

Rayyan Abdelnabi

Radiology, University of Khartoum, Khartoum, SDN

Ahmed Osman

Radiology, Leeds University Hospitals NHS Trust, Leeds, GBR

Waiel A. Bashari Corresponding Author

Institute of Metabolic Science, Cambridge University Hospital, Cambridge, GBR

Ethics Statement and Conflict of Interest Disclosures

Human subjects: Consent was obtained by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.


We acknowledge the departments of Radiology and Community Medicine at the Faculty of Medicine - University of Khartoum, for their support in the conduct of our outreach clinic.

Case report

Applying Telemedicine Technology in Treating Prolactinomas: A Case Report

Figures etc.


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