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Case report

Extracapsular Hepatocellular Adenoma: A Diagnostic Dilemma


Hepatocellular adenoma (HCA) is a benign neoplasm of the hepatic parenchyma. The use of oral contraceptives (OCP) in women is the most well-established risk for the development of HCA. HCA commonly presents as an intracapsular mass of the liver but there are very few cases of extracapsular HCA. This is a case of a middle-aged female who presented to the emergency department with left shoulder pain and epigastric tenderness on physical exam. Subsequent imaging of the abdomen revealed a mass arising from the anterior wall of the stomach, with evidence of surrounding hemorrhage. The patient underwent exploratory laparotomy that revealed free blood in the peritoneum and a hemorrhagic mass arising from the stomach wall. The mass was successfully removed with no postoperative complications. Histopathological examination of the mass was consistent with an infarcted inflammatory HCA. This case illustrates this unusual presentation of a rare diagnosis. 


A hepatocellular adenoma (HCA) is a benign proliferation of mature hepatocytes and consists 2% of all liver neoplasms [1,2]. Its estimated incidence is 1/1,000,000 per year in the general population and 3-4 per 100,000 in women on long-term oral contraceptives (OCP) as opposed to 0.13 per 100,000 in non-OCP-users [3]. HCA is almost always intracapsular and cases originating from an ectopic liver are extremely rare with three other cases reported in the English literature. Herein, we report a unique case of complicated extracapsular HCA presenting with left shoulder pain. 

Case Presentation

A 43-year-old woman presented to the emergency department with a two-day history of left shoulder pain. The patient described the shoulder pain as sharp, constant, and non-radiating. She did not have any known past medical or surgical histories, and her only medication was OCP pills. On review of systems, she reported epigastric discomfort without nausea, vomiting, lack of appetite or recent weight changes. On physical exam, the patient was tachycardic with otherwise stable vital signs. Abdominal exam revealed epigastric tenderness with no guarding or rebound. Initial laboratory work is depicted in Table 1.

Lab Result Lab range
White cell count 10.31 4-12 K/mm3
Red cell count 4.04 4-5.2 M/mm3
Hemoglobin 12.6 12-16 gm/dL
Hematocrit 35.7 37-47%
Platelet count 347 130-400 K/mm3
Sodium 138 136-145 mmol/L
Potassium 4.2 3.7-5.1 mmol/L
Chloride 104 98-107 mmol/L
Carbon Dioxide 25 21-32 mmol/L
Blood urea nitrogen (BUN) 19 7-18 mg/dL
Creatinine 0.78 0.55-1.3 mg/dL
Glucose 136 74-106 mg/dL
Calcium 8.7 8.4-10.1 mg/dL
Total bilirubin 0.8 0.2-1.5 mg/dL
Aspartate aminotransferase (AST) 58 10-37 IU/L
Alanine aminotransferase (ALT) 58 12-78 IU/L
Alkaline phosphatase 42 45-117 IU/L
Total protein 7.6 6.4-8.2 g/dL
Albumin 3.8 3.4-5.0 g/dL
Lipase 114 73-393 unit/L

Initial computed tomography (CT) scan of the abdomen revealed a large heterogeneously enhancing mass arising from the anterior wall of the stomach with a small amount of free fluid surrounding the liver and a moderate amount of fluid in the pelvis (Figure 1).

Contrast-enhanced magnetic resonance imaging (MRI) of the abdomen demonstrated an hypoenhancing exophytic mass from the anterior wall of the stomach with evidence of small volume internal and adjacent hemorrhage. The mass measured 4 x 7.2 x 8 cm in maximum anteroposterior, transverse, and craniocaudal dimensions (Figure 2).

Subsequently, the patient underwent an exploratory laparotomy, which revealed free blood with a large amount of blood clots occupying the greater curvature between the stomach and spleen. An infarcted, hemorrhagic, ovoid mass was seen between the fundus of the stomach, diaphragm, and spleen, which was separate from spleen, liver, and greater curvature slightly attached to the diaphragm. Removal of intraabdominal mass was done successfully and followed by biopsies taken from the omentum. Patient had an uncomplicated surgery and remained asymptomatic in the following days. Initially, the lesion was thought to be an accessory spleen on gross examination and the vicinity. The pathological exam of the surgical piece revealed an infarcted, hemorrhagic mass composed of cords of degenerated epithelioid cells with vacuolated and occasionally lipid-laden cytoplasm (Figure 3). Large, dilated vessels with thrombi within some of them and papillary endothelial hyperplasia were noted. Fibro- and myofibroblastic tissue surrounded the mass. Morphologically the epithelioid cells were reminiscent of hepatocytes, and the provided immunohistochemical stains showed them to be diffusely positive for HerPar-1 (hepatocyte origin), cytokeratin (CK) AE1/AE3 and negative for cluster of differentiation (CD)117. There was focal immunoreactivity for CD31 and CD34 between the cell cords. These findings were most consistent with an infarcted inflammatory HCA associated with the reactive papillary endothelial hyperplasia.


The HCA is a rare, benign tumor derived from hepatocytes [1]. The prevalence of these lesions has been rising, given the recent increase in the use of OCP pills and the abdominal imaging modalities [2]. Among the well-known risk factors of HCA are OCP and anabolic steroid use, pregnancy, glycogen storage diseases, and steatohepatitis. OCP use is by far the strongest risk factor, and the dose-dependent association with estrogen prompted the reduction in estrogen dose in the combination OCPs [1-3]. Bleeding (25%), or malignant transformation (5%) can complicate the disease and result in severe abdominal pain [1]. In females, the lesions <5 cm with no associated symptoms or complications can be managed conservatively by terminating the use of OCP, and repeat surveillance imaging. The European guidelines recommend repeat MRI of the abdomen in six months, followed by annual imaging if the tumor is less than 5 cm and is stable in size [4]. The American College of Gastroenterology recommends follow up CT or MRI of the abdomen at six to twelve-month intervals [5]. The duration of monitoring is based on the growth pattern and stability of the lesion over time. Surgical resection is recommended in males due to the higher risk of malignant transformation [1,6,7]. HCA is almost always intracapsular, and to the best of our knowledge, there are only three cases of extracapsular HCA reported in the English literature [8,9]. Our case had a solitary extracapsular HCA complicated with necrosis and intraperitoneal hemorrhage. Another interesting part of this case was the initial presentation with left shoulder pain, which was likely a consequence of phrenic nerve irritation from intraperitoneal bleeding, also known as Kehr’s sign [10]. On initial imaging studies, due to the vicinity and imaging characteristics, the mass was suggested to be originating from the anterior wall of the stomach. Additionally, during surgery, the location of the tumor between the spleen and the stomach resulted in a diagnostic dilemma as the ectopic liver was initially thought to be an accessory spleen.

This work has been already presented as an abstract. (Abstract: Comba I, Henriquez R, Kumar S, Srinivasamurthy R, Wallis-Crespo M, Karasik O, Bhatia L. Extracapsular Hepatocellular Adenoma: A Diagnostic Dilemma. American College of Gastroenterology 2019 Annual Scientific Meetings; October 2019). https://journals.lww.com/ajg/FullText/2019/10001/Extracapsular_Hepatocellular_Adenoma__A_Diagnostic.2470.aspx


In this report, we aimed to enhance clinicians’ understanding of uncommon presentations of HCA. With recent increase in the prevalence of this condition, especially among patients on OCPs, timely diagnosis and prompt intervention are likely to reduce life-threatening complications.


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  2. Katabathina VS, Menias CO, Shanbhogue AKP, Jagirdar J, Paspulati RM, Prasad SR: Genetics and imaging of hepatocellular adenomas: 2011 update. Radiographics. 2011, 31:1529-1543. 10.1148/rg.316115527
  3. Chang YC, Hernandez-Prera JC, Roayaie S, Schwartz M, Thung SN: Changing epidemiology of hepatocellular adenoma in the United States: review of the literature. Int J Hepatol. 2013, 1-7:10.1155/2013/604860
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  6. Barthelmes L, Tait IS: Liver cell adenoma and liver cell adenomatosis. HPB (Oxford). 2005, 7:186-196. 10.1080/13651820510028954
  7. Agrawal S, Agarwal S, Arnason T, Saini S, Belghit J: Management of hepatocellular hdenoma: recent advances. Clin Gastroenterol Hepatol. 2015, 13:1221-1230. 10.1016/j.cgh.2014.05.023
  8. Derebey M, Karabicak I, Yuruker S, et al.: A first report of synchronous intracapsular and extracapsular hepatic adenoma. Case Rep Surg. 2017, 2017:1-3. 10.1155/2017/9053568
  9. Leone N, Saettone S, De Paolis P, et al.: Ectopic livers and related pathology: report of three cases of benign lesions. Dig Dis Sci. 2005, 50:1818-1822.
  10. Lowenfels AB: Kehr's sign--a neglected aid in rupture of the spleen. N Engl J Med. 1966, 274:1019. 10.1056/NEJM196605052741810

Case report

Extracapsular Hepatocellular Adenoma: A Diagnostic Dilemma

Author Information

Hiffsa Taj Corresponding Author

Internal Medicine, University of Central Florida College of Medicine, Orlando, USA

Isin Comba

Internal Medicine, University of Central Florida College of Medicine, Orlando, USA

Sundeep Kumar

Cardiovascular Disease, Saint Louis University Hospital, St. Louis, USA

Internal Medicine, University of Central Florida College of Medicine, Orlando, USA

Bhatia Lakhinder

Gastroenterology, Osceola Regional Medical Centre, Orlando, USA

Ethics Statement and Conflict of Interest Disclosures

Human subjects: Consent was obtained by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.


Disclaimer: This research was supported (in whole or in part) by HCA Healthcare and/or an HCA Healthcare affiliated entity. The views expressed in this publication represent those of the author(s) and do not necessarily represent the official views of HCA Healthcare or any of its affiliated entities.

Case report

Extracapsular Hepatocellular Adenoma: A Diagnostic Dilemma

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