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Case report

Syncope in an Adolescent


Syncope is a common chief complaint in the emergency department (ED); however, the workup of syncope is quite extensive. Likewise, community-acquired pneumonia (CAP) can also be difficult to diagnose due to the wide range of signs and symptoms, and even a larger list of etiologies. Syncope as a presenting symptom of CAP has demonstrated to be a challenging clinical association to make. We present a case of a previously healthy 14-year-old female who presented to the ED for having an episode of syncope at softball practice. Notable aspects of the case-age of the patient and the obscure presentation, as well as laboratory and imaging results-made this case challenging. Thus, obtaining a thorough history from the patient and family and performing a detailed physical examination can really help a clinician lead to an accurate diagnosis.


Syncope is a common chief complaint in the emergency department (ED); however, the workup of syncope is quite extensive. Defined as a brief loss of consciousness caused by hypoperfusion of the brain, syncope has many causes, including cardiogenic, vasovagal, orthostatic, and neurologic, and is associated with a vast differential diagnosis. Yet, up to a third of syncopal episodes have an unknown etiology. We present a case of a healthy adolescent who presented to the ED after having an episode of syncope and will review the diagnostic considerations and pathophysiology behind the final diagnosis.

Case Presentation

A healthy 14-year-old female was brought to the ED after experiencing a syncopal episode at softball practice. She did not recall experiencing any dizziness, chest pain, shortness of breath, palpitations, or trauma prior to the event. Within approximately one minute, she became nauseated and started experiencing chest pressure, shortness of breath, non-productive cough, and trace amount of blood coming out of her mouth. She was aware of having a syncopal episode and denied being confused. Per bystanders, the patient’s eyes rolled into the back of her head, but she did not have seizure activity. She endorsed starting birth control pills two months prior. Last menstrual period was one week ago, regular, lasted three to four days, and without heavy flow. The patient mentioned that she skipped lunch before practice; however, she denies any recent dieting, allergies, over-the-counter or illicit drug use, past medical problems, or surgical history.

Vital signs upon presentation were as follows: temperature of 98.0o F, pulse rate of 123 beats per minute, respiratory rate of 18 breaths per minute, blood pressure of 130/78 mmHg, and oxygen saturation of 98% on room air. Physical examination demonstrates the following:

● General: awake, alert and oriented, well-nourished, and in no acute distress.

● HEENT (head, eyes, ears, nose, and throat): the head is normocephalic and atraumatic. Pupils are equal, round, and reactive to light and accommodation; extraocular muscles are intact. Ear, nose, and throat present with moist, mucous membrane with no active bleeding.

● Cardiovascular: tachycardia with regular rhythm but without murmurs.

● Pulmonary: clear breath sounds, except for trace wheezing in the right middle lobe.

● Abdomen: Soft, non-tender, non-distended, and without organomegaly.

● Musculoskeletal: grossly normal; full range of motion without edema in the upper or lower extremities.

Laboratory studies at the ED showed a D-dimer count of 3.24 mg/L (normal range: 0.19-0.59 mg/L). All other studies including, troponin, complete blood count, complete metabolic panel, and HCG (human chorionic gonadotropin) serum quantity were within normal limits. Subsequent tests of brain natriuretic peptide, lactic acid, procalcitonin, urine analysis, and urine drug screen were also within normal limits (Table 1-5). Two-view chest X-ray was normal, and EKG (electrocardiogram) showed sinus tachycardia (Figures 1-3). CT of the brain without contrast was normal, and CT angiography of the chest did not show pulmonary emboli (Figures 4, 5).


Test Result Reference Units
Sodium (Na) 139 137-144 mmol/L
Potassium (K) 3.8 3.5-5.0 mmol/L
Chloride (Cl) 108 98-108 mmol/L
Carbon dioxide (CO2) 25 21-32 mmol/L
Anion gap 10 0-40 mmol/L
Glucose 101 55-115 mg/dL
Blood urea nitrogen (BUN) 12 7-18 mg/dL
Creatinine 0.9 0.6-1.3 mg/dL
Total protein 7.7 6.4-8.2 g/dL
Albumin 4.2 3.4-5.0 G/dL
Globulin 3.5 (H) 2.1-3.4 g/dL
Albumin/globulin ratio 1.2 1.0-2.6  
Calcium 9.8 8.5-10.1 mg/dL
Total bilirubin 0.4 0.0-5.0 mg/dL
Aspartate aminotransferase (SGOT/AST) 15 15-37 units/L
Alanine aminotransferase (SGPT/ALT) 21 12-78 units/L
Alkaline phosphatase (ALKP) total 89 50-390 units/L
Test Result Reference Units
White blood cell (WBC) 14.5 6.2-19.9 K/mm3
Red blood cell (RBC) 4.9 4.5-6.30 mil/mm
Hemoglobin (Hb) 14.7 12.1-15.9 G/DL
Hematocrit (Hct) 41.9 35.8-46.9 %
Mean corpuscular volume (MCV) 86 80-100 um3
Mean corpuscular hemoglobin (MCH) 30 27-3 pg
Mean corpuscular hemoglobin concentration (MCHC) 35 32-36 %
Red cell distribution width (RDW) 12 11.5-14.5 %
Platelet count 292 140-450 K/mm3
Granulocytes, % 80.1 54-80.7 %
Absolute neutrophils, n 11.6   K/mm3
Absolute lymphocytes, % 12.4 9.6-32.6 %
Absolute monocytes, % 7 0-8 %
Absolute eosinophils, % 0.1 (L) 0.3-5.4 %
Absolute basophils, % 0.1 0.1-2.6 %
Immature granulocytes, % 0.3   %
Test Result Reference Units
D-dimer quantitative 3.24 (H) 0.19-0.59 mg/L
Procalcitonin <0.05 0.0-0.25 ug/L
Lactic acid 2 0.4-2.0 mmol/L
Brain natriuretic peptide (BNP) <5 0-100 pg/mL
Human chorionic gonadotropin (HCG) serum quantitative <1 0-3 mIU/mL
Troponin I <0.02 0.015-0.044 ng/mL
Test Result Reference
UA color Straw Yellow
UA appearance Hazy Clear
UA glucose Negative Negative
UA bilirubin Negative Negative
UA ketones Negative Negative
UA specific gravity 1.011 1.010-1.030 
UA blood 6 5.0-8.0
UA pH Negative Negative
UA protein Negative  
UA urobilinogen Negative Negative
UA leukocyte esterase Negative Negative
UA microscopic NO (A)  
Test Results Reference
UR cocaine Negative Negative
UR tetrahydrocannabinol (THC) Negative Negative
UR amphetamine Negative Negative
UR tricyclic antidepressants (TCA) Negative Negative
UR barbiturate Negative Negative
UR benzodiazepines QL Negative Negative
UR methadone QL Negative Negative
UR opiates QL Negative Negative

After completing an initial history and physical examination in the ED, differential diagnosis included the following:

● Acute pulmonary embolism due to recent start of oral contraceptive pills.

● Syncope with a vasovagal or cardiac origin.

● Seizure.

Furthermore, having an elevated D-dimer, as well as the patient’s dyspnea, chest pressure, cough, and tachycardia made acute pulmonary embolism top of the differential diagnosis. However, CT angiography of the chest was negative. Likewise, with a combination of bystander description, laboratory workup being non-contributory, and CT of the brain within normal limits, clinical suspicion of a seizure was decreased. Lastly, cardiogenic cause of syncope was unlikely based on EKG interpretation and laboratory results. The patient remained in stable condition, with no indication for hospital admission, and was discharged from the ED with an impression of syncope due to a vasovagal reaction, which may have been triggered by a combination of dehydration, skipping a meal, and a bout of coughing during softball practice.

Her mother contacted a pediatrician and scheduled an appointment for further evaluation the next day. Six hours prior to the office visit the following day, the patient mentioned feeling faint while walking down the stairs at home, with no loss of consciousness, which quickly resolved without any interventions. The patient’s mother also complained that the patient had a low-grade fever two days prior to the initial visit to the ED and denied having a history of asthma. On review of systems, she continued to endorse a persistent, non-productive cough, chest pressure, and shortness of breath, and had developed a sore throat. All other systems were non-contributory. Vital signs, in the supine position, were as follows: temperature of 98.0o F, pulse rate of 82 beats per minute, respiratory rate of 16 breaths per minute, and blood pressure of 116/72 mmHg. S1/S2 heart sounds were present but without murmurs. Pulmonary examination demonstrated clear breath sounds bilaterally. Five minutes later in the sitting position, pulse rate was 84 beats per minute and blood pressure was 112/70 mmHg. The patient was started on empiric antibiotic azithromycin for the treatment of suspected atypical community-acquired pneumonia (CAP) and was also prescribed an albuterol inhaler for suspected bronchospasm caused by cough syncope. At that time, she had blood taken to test for TSH, T4, and Mycoplasma pneumoniae IgM Ab.

On a follow-up visit three days later, test results showed Mycoplasma pneumoniae IgM Ab level of 1,947 U/mL (reference: 0-769 U/mL), and TSH and T4 within normal limits (Table 6). All of her symptoms, including persistent, non-productive cough, chest pressure, shortness of breath, and throat soreness, had resolved. She was told to finish her course of azithromycin and use an albuterol inhaler as needed before softball practice.

Test Result Reference Units
Thyroid-stimulating hormone (TSH) 1.860 0.450-4.50 uIU/mL
Thyroxine (T4) 8.8 4.5-12.0 ug/dL
Mycoplasma pneumoniae IgM Ab 1947 (H) 0-769 U/mL


CAP continues to be a significant cause of morbidity across the world. Even with improvements in early detection and disease management, studies show that the economic burden of CAP in adults in the United States is upwards of $17 billion annually [1]. The number is even higher if you include the pediatric populations. Furthermore, atypical CAP usually presents with less severe symptoms and often goes untreated. This requires physicians to have a broad knowledge base and often a high index of suspicion in order to recognize various signs and symptoms of atypical pneumonia.

At the pediatrician's office, the patient primarily endorsed a history of low-grade fever, persistent and non-productive cough, chest pressure, shortness of breath, and sore throat. This steered the clinical suspicion toward the respiratory system. Atypical CAP was high on the differential despite a normal chest X-ray in the ED (Figures 12). This is because at an early stage of pneumonia, chest X-ray can often be normal and not show the typical presentation of atypical pneumonia, that is, diffuse reticulonodular perihilar infiltrates [2-3]. This requires keen judgment of the physician to often diagnose atypical pneumonia clinically.

In the patient’s age group, the most common agent for atypical CAP is Mycoplasma pneumoniae. Primary clinical manifestations of Mycoplasma pneumoniae include upper respiratory tract infection and pneumonia. Other known non-respiratory manifestations are mucocutaneous disease (mild erythematous maculopapular rash, urticaria, etc.) and cold agglutinin hemolysis [4-5].

The pathophysiology behind Mycoplasma pneumoniae causing an elevated D-dimer level is not fully understood. Current theories postulate that the disruption of the vascular endothelial membrane and imbalance between coagulation factors caused by direct invasion by the organism, toxin production, immune-mediated response, or cytokine production can tip the scale toward a hypercoagulable state [6]. Even though unnecessary for diagnostic purposes, a coagulation profile would have also been beneficial to help explain the reason behind the elevated D-dimer level in our patient in the ED.

Macrolides, in particular azithromycin, are considered to be the treatment of choice for atypical pneumonia, especially with Mycoplasma pneumonia being the causative agent. Tetracyclines, such as doxycycline, and respiratory fluoroquinolones, such as moxifloxacin or levofloxacin, can also be used as alternative treatments, especially in areas with high macrolide resistance [7]. Our patient showed significant improvement even after two days of azithromycin 250 mg orally once daily but was advised to finish the full five-day course. She was also prescribed an albuterol inhaler 2.5 mg (two puffs) inhaled orally twice a day and 20-30 minutes before each softball practice.


Atypical CAP presenting with syncope is often difficult to diagnose, especially when syncope is not a typical symptom of atypical CAP. It is vital to increase the index of suspicion among clinicians of this unusual presentation of atypical pneumonia in adolescents and emphasizes the value of obtaining a thorough history from the patient and family and performing a detailed physical examination.


  1. File TM, Marrie TJ: Burden of community-acquired pneumonia in North American adults. Postgrad Med. 2015, 122:130-141. 10.3810/pgm.2010.03.2130
  2. Maughan BC, Asselin N, Carey JL, Sucov A, Valente JH: False-negative chest radiographs in emergency department diagnosis of pneumonia. R I Med J. 2014, 97:20-23.
  3. Miyashita N, Sugiu T, Kawai Y, et al.: Radiographic features of Mycoplasma pneumoniae pneumonia: differential diagnosis and performance timing. BMC Med Imaging. 2009, 9:7. Accessed: January 9, 2020: 10.1186/1471-2342-9-7
  4. Kashyap S, Sarkar M: Mycoplasma pneumonia: clinical features and management. Lung India. 2010, 22:75-85. 10.4103/0970-2113.63611
  5. Narita M: Classification of extrapulmonary manifestations due to mycoplasma pneumoniae infection on the basis of possible pathogenesis. Front Microbiol. 2016, 7:23. Accessed: January 9, 2020: 10.3389/fmicb.2016.00023
  6. Jin X, Zou Y, Zhai J, Liu J, Huang B: Refractory Mycoplasma pneumoniae. Medicine (Baltimore). 2018, 97:10.1097/MD.0000000000010103
  7. Mandell LA, Wunderink RG, Anzueto A, et al.: Infectious Diseases Society of America/American Thoracic Society Consensus Guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis. 2007, 44: S27-S72. https://doi.org/10.1086/511159
Case report

Syncope in an Adolescent

Author Information

Hardik Patel Corresponding Author

Pediatrics, Raleigh General Hospital, Beckley, USA

Pediatric Medicine, Beckley Appalachian Regional Healthcare, Beckley, USA

Nick Chatla

Pediatrics, Raleigh General Hospital, Beckley, USA

Ahmad Khiami

Pediatrics, Raleigh General Hospital, Beckley, USA

Pediatrics, Beckley Appalachian Regional Healthcare, Beckley, USA

Pediatrics, West Virginia University, Morgantown, USA

Ethics Statement and Conflict of Interest Disclosures

Human subjects: Consent was obtained by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Case report

Syncope in an Adolescent

Figures etc.


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