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Case report
peer-reviewed

Iatrogenic Direct Carotid-cavernous Fistula Following Mechanical Thrombectomy: A Case Report and Review of the Literature



Abstract

A carotid-cavernous fistula (CCF) is an abnormal connection between the arteries and veins of the cavernous sinus. Iatrogenic CCFs have been described as potential complications following aneurysm coiling, balloon angioplasty, and transsphenoidal surgery. In this case report, we describe a rare case of an iatrogenic direct CCF following mechanical thrombectomy (MT) for acute ischemic stroke. A 78-year-old female presented to an outside hospital with a new onset of right-sided weakness and aphasia and underwent emergency MT for a left middle cerebral artery (MCA) occlusion. The procedure was complicated by iatrogenic injury to the left cavernous internal carotid artery (ICA), which resulted in a direct high-flow CCF. The patient was transferred to our hospital and the fistula was closed with transarterial coils. Ten days later, she returned with diplopia and cranial nerve VI palsy due to residual pseudoaneurysm and was treated with a flow-diverting stent. On follow-up, the patient was neurologically intact and imaging showed no residual fistula. As the frequency of MTs performed for acute ischemic stroke continues to rise, neurointerventionalists should be aware of this potential rare complication and be prepared to manage patients who develop symptomatic CCF.

Introduction

A carotid-cavernous fistula (CCF) is an abnormal connection between arteries and veins within the cavernous sinus. CCFs have been classified according to hemodynamic properties (high-flow vs. low-flow), etiology (spontaneous vs. traumatic/iatrogenic), and anatomical feeders (direct vs. indirect). A direct high-flow CCF results from a tear in the wall of the cavernous internal carotid artery (ICA), thereby shunting blood from the ICA to the cavernous sinus. Iatrogenic high-flow CCFs have been described as a complication in approximately 0.8% of endovascular interventions involving the anterior circulation including elective aneurysm coiling, intracranial balloon angioplasty, and mechanical thrombectomy (MT) [1-4]

The number of MTs performed in the United States for acute ischemic stroke is steadily rising due to the mounting evidence of its benefit in select patients, as it can limit disability from stroke even up to 24 hours [5-9]. However, in rare circumstances, endothelial injury by microwire manipulation or pulling of the stent retriever through the cavernous ICA during MT can cause vessel injury. In this article, we present a rare case of an iatrogenic direct CCF following MT for acute ischemic stroke and engage in a review of the related literature.

Case Presentation

A 78-year-old female with a past medical history of hypertension and breast cancer presented to an outside hospital with aphasia and right hemiplegia after a syncopal episode with a National Institutes of Health Stroke Score (NIHSS) of 18. The patient underwent an emergency MT for a left middle cerebral artery (MCA) occlusion, and successful revascularization was achieved after two passes with a stent retriever. The procedure was complicated by iatrogenic injury of the left cavernous ICA, resulting in a direct high-flow CCF. The patient was referred to our center a few days later after an unsuccessful attempt to occlude the fistula. On arrival at our center, the patient had fully recovered from her previous left MCA stroke with an NIHSS of 0 and no neurologic deficit. She was on a daily antiplatelet regimen of aspirin 81 mg. The patient was asymptomatic from the direct CCF, and an ophthalmology examination revealed normal extra-ocular movements, normal visual acuity, and normal ocular tension (measured by tonometry; Tono-Pen, Reichert Technologies, Depew, NY) in both eyes (right 16 mm Hg and left 17 mm Hg).

After reviewing the angiographic images from the outside hospital, the decision was made to proceed with diagnostic cerebral angiogram and transarterial embolization of the left CCF (Figure 1). After completing a full six-vessel diagnostic cerebral angiogram, balloon test occlusion of left ICA was done using a 4 x 10-mm compliant TransForm balloon (Stryker Corporation, Kalamazoo, MI) that was inflated across the injured segment of left cavernous ICA. Injection from the right internal carotid was done and demonstrated a “grey zone” result with a venous delay of 1.8 seconds between the two hemispheres. Given the balloon test occlusion result, transarterial CCF embolization was favored over therapeutic ICA sacrifice as the treatment for this specific case. Thereafter, the microcatheter was navigated transarterially through the hole in the left ICA into the left cavernous sinus and left superior ophthalmic vein (SOV). After the satisfactory positioning of microcatheter in the distal left SOV, coil embolization was performed in a retrograde fashion from the SOV toward the cavernous sinus near the communication with the injured cavernous ICA. We were unable to deploy the final coil at the fistulous point as it was protruding into the parent vessel (ICA) even with balloon assistance. Minimal slow residual shunting was seen in a posterior venous pouch draining into the pterygopalatine plexus at the conclusion of the procedure. No residual ophthalmic venous drainage was seen. There were no complications, and the patient was discharged neurologically intact the following day on antiplatelet therapy with aspirin 325 mg and Plavix 75 mg in preparation for further treatment of residual fistula with flow diverter embolization.

The patient returned 10 days later with diplopia, headaches, and tinnitus. Physical exam revealed a lateral gaze palsy in her left eye. On angiogram, no residual CCF was visualized; however, a residual pseudoaneurysm was observed in the left cavernous ICA at the previous location of the fistula shunting point (Figure 2). Considering the initial mechanism of injury and the new symptoms experienced by the patient, the decision was made to proceed with pipeline embolization of this residual ICA pseudoaneurysm. A coaxial system of an 088” ID guide catheter, an intermediate catheter (060” Syphontrak, Codman Neuro, Raynham, MA), and 027” Phenom microcatheter (Medtronic, Minneapolis, MN) were placed into the left supraclinoid ICA, and a Pipeline Flex 3.5 mm x 16 mm (Medtronic, Minneapolis, MN) device was deployed to cover the neck of the left cavernous ICA pseudoaneurysm. The procedure was uncomplicated and the patient remained asymptomatic at the six-month follow-up. Follow-up CTA showed no residual fistula or aneurysm.

Discussion

The Barrow classification categorizes CCFs into four types: Type A fistulas are direct connections between the ICA and cavernous sinus, and Type B, C, and D fistulas are all indirect dural shunts from meningeal branches of the ICA, external carotid artery (ECA), or both, respectively [10]. The etiology of direct Type A CCFs typically includes blunt or penetrating trauma, ICA aneurysm rupture, Ehlers-Danlos syndrome type IV, or rarely, iatrogenic interventions [11]. Additionally, CCFs are more frequently reported in female patients, suggesting a differential vascular weakness between the sexes [1]. The patient in our case was a female without any known vascular predisposing risk factors presenting with iatrogenic direct CCF.

Type A fistulas often present with severe symptoms due to the high-flow fistulous connection between the ICA and cavernous sinus. Patients may present with chemosis, orbital congestion, proptosis, double vision, cranial nerve dysfunction, ocular bruit, and increased intraocular pressure leading to central retinal vein occlusion or optic neuropathy [11]. Cranial nerve VI palsies frequently occur due to the sixth nerve location adjacent to the ICA, compared to the more lateral location of other cranial nerves within the cavernous sinus. Treatment of these fistulas by endovascular occlusion of the fistula usually resolves with the rapid resolution of symptoms.

To our knowledge, there are only three other studies in the literature describing iatrogenic direct CCF following MT (Table 1). Alan et al. reported three cases of Type A CCFs that occurred following MT for acute ischemic stroke [3]. In the first case, the patient presented with a tandem occlusion of the right ICA and MCA that was treated with stenting of the cervical ICA and three passes of the stent retriever with local aspiration. A small CCF was noted postoperatively, however, the patient had a poor neurologic outcome and treatment was not pursued. The patient’s CCF remained asymptomatic after 1.5 years of follow-up. In the second case, a CCF was noted in a patient after two passes of stent retriever thrombectomy with local aspiration for a left ICA terminus occlusion. The CCF was managed conservatively, and the patient remained asymptomatic at the four-month follow-up. In the third case, a patient with a tandem right ICA and MCA occlusion underwent thrombectomy with two passes of the stent retriever. However, overnight, there was complete re-occlusion of the ICA, which required angioplasty and stenting of the cervical carotid, stenting of the cavernous/lacerum carotid, and manual aspiration thrombectomy of an iatrogenic right MCA occlusion. A CCF was observed at the conclusion of the procedure but was not treated. Two weeks after discharge, the patient developed proptosis, chemosis, and a right cranial nerve VI palsy. Embolization was performed via a transvenous inferior ophthalmic vein approach with a complete resolution of symptoms. Similarly, Matsumoto et al. reported a case of MT for a right M1 proximal occlusion where strong resistance was felt during the first pass of stent retriever withdrawal [12]. This resulted in a stretch of the cavernous ICA by the anchoring of the balloon and stent retriever, resulting pullout injury to the meningohypophyseal trunk and CCF. Symptoms initially related to the CCF included hyperemia and chemosis. The CCF was treated three weeks after thrombectomy with transvenous coil embolization via an inferior petrosal sinus approach. Postoperatively, the ocular symptoms disappeared and there was no ocular movement disorder at the three-month follow-up. 

Literature review of iatrogenic direct CCF following mechanical thrombectomy
Author Alan et al. [3] Akpinar et al. [2] Matsumoto et al. [12] Current study
Case 1 Case 2 Case 3
Site of occlusion Tandem right ICA terminus and MCA Left ICA terminus to left M1 Right ICA (petrous, lacerum, proximal cavernous segment), proximal right M1 Right distal ICA and right MCA Right M1 Left MCA
Number of passes 1 2 1 NA 1 2
Procedure Stent retriever thrombectomy with local aspiration; stenting of cervical carotid Stent retriever thrombectomy with local aspiration Stenting of the cervical/cavernous/lacerum carotid; manual aspiration thrombectomy Stent retriever thrombectomy with local aspiration Stent retriever thrombectomy Stent retriever thrombectomy with local aspiration
Initial CCF symptoms Asymptomatic Asymptomatic Right CN VI palsy, proptosis, chemosis (asymptomatic after 2 weeks) NA Chemosis, hyperemia Asymptomatic
Management of CCF Conservative Conservative Embolization via transvenous inferior ophthalmic vein approach (after initial conservative management) Conservative (ICA was not recanalized) Embolization via transvenous inferior petrosal sinus approach (three weeks post- thrombectomy) Embolization via transarterial approach to superior ophthalmic vein; 10 days later, pipeline embolization of residual pseudoaneurysm
Follow-up 1.5 years: asymptomatic  4 months: asymptomatic  2.5 years: asymptomatic  Died 2 days postoperatively 3 months: asymptomatic 6 months: asymptomatic 

In a retrospective analysis, Akpinar et al. assessed complications of 28 consecutive stroke patients and reported one case of CCF following MT of a right ICA terminus occlusion [2]. The ICA terminus was not recanalized and the patient died a few days later. 

In all the patients who developed a CCF after thrombectomy, a stent retriever was used and multiple passes were required. Both aspiration and stent retriever thrombectomy have been shown to cause vessel wall damage in animal models. However, stent retriever thrombectomy appears to cause more aggressive damage with areas of complete denudation of the endothelium after just one pass on histology [13]. Repeated passes of the stent retriever may further increase the acute damage, weakening the vessel wall, and likely increasing the risk for subsequent perforation or CCF.

In general, Type A traumatic CCFs are unlikely to close spontaneously, and there is a risk of progression with approximately 20% of patients requiring emergency treatment secondary to acute decreases in visual acuity, increases in intraocular pressure, or intracranial hemorrhage [14]. However, the natural history of iatrogenic Type A fistulas by the navigation of the microwire or stent retriever remains unclear. While two patients in the Alan et al. series remained asymptomatic on short-term follow-up, only 25% of patients had spontaneous resolution of iatrogenic CCF in a series examining all neurointerventional procedures [1]. Further studies are necessary to determine if the decision to treat thrombectomy-associated CCFs should be delayed until the patient becomes symptomatic or dependent on particular qualities of the fistula. 

Treatment options for CCF include surgery, radiosurgery, or endovascular interventions. In cases of direct CCF, the first-line treatment is endovascular occlusion, which may be accomplished using stand-alone coiling, stent-assisted coiling, detachable balloons, liquid embolic agents, or a combination of these strategies [4,11,15]. After CCF occlusion, pseudoaneurysm formation may occur and is typically managed conservatively unless the patient is symptomatic. The CCF in our case was treated by coil embolization via a direct transarterial approach followed by flow-diverting stent placement for a symptomatic residual pseudoaneurysm of the ICA.

Conclusions

We presented a rare case of iatrogenic direct CCF following MT for acute ischemic stroke. As the popularity of endovascular treatment for acute ischemic stroke continues to increase, it is important for neurointerventional operators to be aware of potential iatrogenic direct CCF complications, particularly in cases requiring multiple passes of a stent retriever, angioplasty, or stent placement.


References

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  2. Akpinar SH, Gelener P, Kaymakamzade B: Complications of endovascular treatment in acute stroke patients: results from a tertiary referral center. Int J Stroke. 2014, 9:88.
  3. Alan N, Nwachuku E, Jovin TJ, Jankowitz BT, Jadhav AP, Ducruet AF: Management of iatrogenic direct carotid cavernous fistula occurring during endovascular treatment of stroke. World Neurosurg. 2017, 100:e15-20. 10.1016/j.wneu.2017.01.112
  4. Kim SH, Qureshi AI, Boulos AS, et al.: Intracranial stent placement for the treatment of a carotid-cavernous fistula associated with intracranial angioplasty. Case report. J Neurosurg. 2003, 98:1116-1119. 10.3171/jns.2003.98.5.1116
  5. Albers GW, Marks MP, Kemp S, et al.: Thrombectomy for stroke at 6 to 16 hours with selection by perfusion imaging. N Engl J Med. 2018, 378:708-718. 10.1056/NEJMoa1713973
  6. Nogueira RG, Jadhav AP, Haussen DC, et al.: Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct. N Engl J Med. 2018, 378:11-21. 10.1056/NEJMoa1706442
  7. Jovin TG, Chamorro A, Cobo E, et al.: Thrombectomy within 8 hours after symptom onset in ischemic stroke. N Engl J Med. 2015, 372:2296-2306. 10.1056/NEJMoa1503780
  8. Berkhemer OA, Fransen PS, Beumer D, et al.: A randomized trial of intraarterial treatment for acute ischemic stroke. N Engl J Med. 2015, 372:11-20. 10.1056/NEJMoa1411587
  9. Goyal M, Demchuk AM, Menon BK, et al.: Randomized assessment of rapid endovascular treatment of ischemic stroke. N Engl J Med. 2015, 372:1019-1030. 10.1056/NEJMoa1414905
  10. Barrow DL, Spector RH, Braun IF, Landman JA, Tindall SC, Tindall GT: Classification and treatment of spontaneous carotid-cavernous sinus fistulas. J Neurosurg. 1985, 62:248-256. 10.3171/jns.1985.62.2.0248
  11. Henderson AD, Miller NR: Carotid-cavernous fistula: current concepts in aetiology, investigation, and management. Eye (Lond). 2018, 32:164-172. 10.1038/eye.2017.240
  12. Matsumoto H, Nishiyama H, Takemoto H, Tetsuo Y, Nakao N: Carotid-cavernous fistula caused by vessel injury while withdrawing a stent retriever during mechanical thrombectomy for acute ischemic stroke: a case report. J Neuroendovascular Ther. 2017, 12:235-240. 10.5797/jnet.cr.2017-0089
  13. Peschillo S, Diana F, Berge J, Missori P: A comparison of acute vascular damage caused by ADAPT versus a stent retriever device after thrombectomy in acute ischemic stroke: a histological and ultrastructural study in an animal model. J Neurointerv Surg. 2017, 9:743-749. 10.1136/neurintsurg-2016-012533
  14. Gemmete JJ, Chaudhary N, Pandey A, Ansari S: Treatment of carotid cavernous fistulas. Curr Treat Options Neurol. 2010, 12:43-53. 10.1007/s11940-009-0051-3
  15. Morón FE, Klucznik RP, Mawad ME, Strother CM: Endovascular treatment of high-flow carotid cavernous fistulas by stent-assisted coil placement. AJNR Am J Neuroradiol. 2005, 26:1399-1404.
Case report
peer-reviewed

Iatrogenic Direct Carotid-cavernous Fistula Following Mechanical Thrombectomy: A Case Report and Review of the Literature


Author Information

Dallas L. Sheinberg Corresponding Author

Neurological Surgery, University of Miami Miller School of Medicine, Miami, USA

Marie-Christine Brunet

Neurological Surgery, University of Miami Miller School of Medicine, Miami, USA

Stephanie H. Chen

Neurological Surgery, University of Miami Miller School of Medicine, Miami, USA

Evan Luther

Neurological Surgery, University of Miami Miller School of Medicine, Miami, USA

Robert M. Starke

Neurological Surgery, University of Miami Miller School of Medicine, Miami, USA


Ethics Statement and Conflict of Interest Disclosures

Human subjects: Consent was obtained by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.


Case report
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Iatrogenic Direct Carotid-cavernous Fistula Following Mechanical Thrombectomy: A Case Report and Review of the Literature


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