Abstract
A 50-year-old man presented with dizziness and hearing disturbance in the right ear. Magnetic resonance imaging (MRI) revealed a well-enhanced mass lesion in the right cerebellopontine (CP) angle that appeared to originate in the cerebellum. A surgical specimen obtained at the subtotal resection with craniotomy revealed a diffuse large B-cell lymphoma (DLBCL). During the three courses of chemotherapy with high-dose methotrexate (MTX) with leucovorin rescue, he developed a right abducens palsy, left oculomotor palsy, left facial palsy, right trigeminal sensory disturbance, and paraparesis. Although the brain MRI showed that the CP angle tumor had disappeared completely following chemotherapy, enhanced lesions along the cauda equina were detected on a lumbar spine MRI. FDG-PET (18 F-fluorodeoxyglucose positron emission tomography) revealed multiple high-uptake abnormalities in the cranial nerves and spinal nerves. Tumor cells were found in the cerebrospinal fluid specimen from a lumbar puncture. Craniospinal irradiation was performed, including all the abnormal FDG high-uptake areas, and was effective in relieving the patient’s symptoms. On FDG-PET, the high-uptake abnormalities in the peripheral nerves disappeared. However, five weeks after the irradiation, he developed right trigeminal sensory disturbance, hoarseness, dysphagia, and right arm pain. FDG-PET disclosed multiple high-uptake abnormalities in more peripheral portions of the cranial nerves and spinal nerves. Chemotherapy with rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine (Oncovin®), and prednisolone (R-CHOP) was then resorted to which mitigated his symptoms. On follow-up FDG-PET, the high-uptake abnormalities in the peripheral nerves disappeared again.
Introduction
Primary non-Hodgkin’s lymphoma (NHL) of the central nervous system (CNS) is uncommon and generally affects the brain [1]. Diffuse large B-cell lymphoma (DLBCL) is the most common form of CNS NHL. Only 1% of primary CNS NHL emerges in the spinal cord. A syndrome of lymphoma and leukemic infiltration of the cranial or peripheral nerves is called neurolymphomatosis (NL) [2-3]. It is a rare clinical entity, with an incidence of 0.2% in all NHL patients [3]. Several studies have reported primary and secondary NL with single and multiple cranial or spinal nerve involvement [1-9]. We present a case of CNS NHL developing NL subsequently during the initial courses of chemotherapy following subtotal surgical resection of the brain lymphoma. As far as we know, this is the first reported case in which primary brain NHL with NL, without other visceral lesions, manifested subsequently during the initial chemotherapy.
Case Presentation
A 50-year-old man suffered from dizziness and hearing disturbance in the right ear. Magnetic resonance imaging (MRI) demonstrated a well-enhanced mass lesion in the right cerebellopontine (CP) angle, which appeared to have originated in the cerebellum (Figure 1).
The surgical specimen taken at the time of the subtotal resection with craniotomy revealed a DLBCL (Figures 2-3).
During the three courses of chemotherapy with high-dose methotrexate (MTX) with leucovorin rescue, he developed a right abducens palsy, left oculomotor palsy, left facial palsy, right trigeminal sensory disturbance, and paraparesis. Although the CP angle tumor on the brain MRI showed complete regression following chemotherapy (Figure 1), enhanced lesions along the cauda equina were detected on lumbar spinal MRI (Figure 4).
Fluorodeoxyglucose positron emission tomography (FDG-PET) revealed multiple high-uptake abnormalities in the cranial nerves and spinal nerves (Figures 5-6).
Tumor cells were found in the cerebrospinal fluid specimen from the lumbar puncture. Craniospinal irradiation was performed, including all the abnormal FDG high-uptake areas (Figure 7), and effectively relieved the patient’s symptoms. On the FDG-PET scan, the high-uptake abnormalities in the peripheral nerves disappeared. However, five weeks after the irradiation, he developed a right trigeminal sensory disturbance, hoarseness, dysphagia, and right arm pain. FDG-PET disclosed multiple high-uptake abnormalities in more peripheral portions of the cranial and spinal nerves (Figure 8).
Chemotherapy consisting of R-CHOP (rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine (oncovin), and prednisolone) was then administered, which began two weeks after the development of recurrent symptoms. We chose R-CHOP, other than ordinal salvage regimens for CNS lymphoma such as high-dose cytosine arabinoside, because his general condition was not good enough after esophagitis was relieved. His symptoms again improved in two weeks after the beginning of R-CHOP. On the FDG-PET scan, taken three months after the beginning of R-CHOP (after three courses of R-CHOP), the high-uptake abnormalities in the peripheral nerves again disappeared. At that time his neurological conditions were good only with dysesthesia in the lower extremities.
Discussion
The lymphomatous infiltration of a nerve root (the cranial or peripheral nerve or multiple nerves) is known as NL or neurolymphomatosis [2]. It is a rare neurologic complication of lymphoma that is poorly recognized by clinicians [2].
Haydaroglu Sahin et al. [4] and Katyal et al. [5] reported a case of NL in multiple cranial nerves. Bourque et al. reported a case of NL in the brachial plexus [6]. Khandelwal et al. presented a case of NL in the left C4 and C5-C8, and L4-L5 and S1-S2 [2]. Broen et al. [1], Sasaki et al. [3], and Marquardt et al. [7] reported cases of NL in the cauda equina or lumbosacral root/plexus. Misdraji et al. reported four cases of NL in the sciatic nerve (two cases), radial nerve, or sympathetic chain and spinal nerve [8]. Del Grande et al. reported a case of NL in the femoral nerve [9].
Gd-enhanced MRI and FDG-PET are the imaging modalities of choice for evaluation of patients with lymphoma and suspected neural involvement [2]. NL is diagnosed by the demonstration of enhancement of nerve roots on MRI of the brachial, lumbosacral plexus, peripheral nerves, or by increased hypermetabolic activity along the course of affected nerves on FDG-PET [2]. Treatment of NL consists of focal radiotherapy and chemotherapy [2]. In our case, NL developed and worsened during chemotherapy with high-dose MTX. Craniospinal irradiation, followed by R-CHOP, were then effective.
Conclusions
A case of primary central nervous system lymphoma presenting with peripheral nerve involvement was described. Recognizing these conditions with an understanding of the rare clinical entity of neurolymphomatosis is necessary for early diagnosis of similar cases. Detailed neurological examination and imaging, including FDG-PET, would be essential to grasp the extent of the disease. Timely assessment with chemotherapy and irradiation, if possible, might improve the patient's neurological status.
References
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Primary Central Nervous System Lymphoma with Peripheral Nerve Involvement: Case Report
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Human subjects: Consent was obtained by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.
Article Information
DOI
10.7759/cureus.5675
Cite this article as:
Mori Y, Yamamoto K, Ohno A, et al. (September 16, 2019) Primary Central Nervous System Lymphoma with Peripheral Nerve Involvement: Case Report. Cureus 11(9): e5675. doi:10.7759/cureus.5675
Publication history
Received by Cureus: August 30, 2019
Peer review began: September 06, 2019
Peer review concluded: September 13, 2019
Published: September 16, 2019
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© Copyright 2019
Mori et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 3.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Primary Central Nervous System Lymphoma with Peripheral Nerve Involvement: Case Report
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