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Original article
peer-reviewed

CyberKnife Ablation for Intramedullary Spinal Cord Arteriovenous Malformations (AVMs): A Promising New Therapeutic Approach



Abstract

Objective: Intramedullary spinal cord arteriovenous malformations (AVMs) are very rare lesions which are characteristically associated with recurrent hemorrhage and progressive ischemia. Although favorable location, size and vascular anatomy make it sometimes possible to manage this condition with embolization and/or microsurgical resection, there are no good treatment options for many, if not most, of these lesions. Given such poor prospects, the senior author began in 1997 investigating CyberKnife radiosurgical ablation as a tool for managing selected patients with intramedullary spinal cord AVMs. Although a previous paper in 2006 reported the preliminary experience from Stanford, our understanding has grown significantly as follow-up was extended and more patients were treated. Herein, we retrospectively analyze our longer term experience with a primary radiosurgical approach to spinal cord AVM.

Methods: Thirty patients (17 females: 13 males) with a median age of 33 years and intramedullary spinal cord AVMs (18 cervical, nine thoracic, and three conus medullaris) were treated with CyberKnife SRS between 1997 and 2008. A history of hemorrhage was present in 57% of cases, while in 50% of patients previous treatment included microsurgery (6/29) or embolization (11/29). The mean AVM volume was 2.8 cc (0.2-15cc) and was treated to mean marginal dose of 20Gy in one to four sessions (median 2). Based on our growing experience, the biologically effective dose (BED) of radiation was escalated gradually over the course of this study. Clinical and magnetic resonance imaging follow-up were carried out annually, and spinal angiography was repeated at three years.

Results: After a mean follow-up period of 63 months (median 54), the treated AVM was completely obliterated in eight cases (27%) and significantly decreased in size in an additional 11 cases (64%) among the 22 angiographically studied patients with more than three years of follow-up. Pre-radiosurgery neurologic symptoms improved in more than 50% of cases, but worsened in three (10%). There was one instance (3%) of radiation-induced myelopathy occurring within one year of radiosurgery. Notably, after 158 years of collective post-SRS follow-up, no patient suffered a hemorrhage.

Conclusions: Although our understanding is still incomplete, CyberKnife radiosurgery results in total obliteration or shrinkage for most intramedullary spinal cord AVM, a phenomenon that may be accompanied by a marked decrease in the risk of bleeding. Symptom improvement is also common in most cases. More experience is required to determine the optimal radiosurgical dosing and consequent related efficacy. Given the significant therapeutic challenges inherent to spinal cord AVM patients, the rate of radiosurgical complications appears acceptable.

Introduction

Intramedullary spinal cord arteriovenous SCAVMs are rare causes of spinal cord ischemia with a proclivity to affect young adults [1-5]. The estimated incidence of these lesions is only 0.02/100,000 person-years while the prevalence is 0.08/100,000 population [6-7]. Although the natural history is not well-characterized, historical studies and more recent case series suggest a significant risk of hemorrhage [3, 5, 8-9], often resulting in paralysis [1, 5]. Despite advances in microsurgery [10] and interventional neuroradiology [3], many of these lesions are still not amenable to such therapies because of their intraparenchymal spinal cord location and/or a common anterior spinal artery blood supply. Furthermore, the risk of complications from these established therapies, even in experienced hands, is considerable [3, 10, 11].

Although the feasibility of using stereotactic radiosurgery to ablate SCAVMs has previously been described [12-13], the extent of treatment benefits and the longer term risk of radiation-induced myelopathy both remain unknown. In this report, we describe our thirteen-year experience with CyberKnife radiosurgery for intramedullary SCAVMs focusing on its radiographic efficacy, alteration in the risk of hemorrhage, and change in clinical symptoms, while also assessing the risk of treatment-related complications.

Materials & Methods

Patients

Between August 1997 and November of 2009, 30 consecutive patients with angiographically visible intramedullary spinal cord arteriovenous malformations underwent CyberKnife stereotactic radiosurgery at Stanford University Medical Center under the auspices of the Institutional Review Board approved prospective study. Given the rarity of spinal cord AVMs, it is not surprising that many of our patients were referred nationally or internationally. Informed consent was obtained from each patient prior to beginning the radiosurgical process. Results of radiosurgery were retrospectively analyzed with radiographic response serving as the primary outcome measure. Secondary endpoints included rate of hemorrhage and improvement in clinical symptoms. 

The selection criterion for radiosurgery involved only the presence of a symptomatic, angiographically-confirmed AVM within the spinal cord, which was felt to be associated with a high risk of spinal cord injury if resected or embolized. Almost all patients met this criterion by having a diffuse nidus encompassing nearly the entire cross sectional area of the spinal cord and/or a predominant blood supply via the anterior spinal artery. In 11 patients, previous endovascular embolization had been performed but residual nidus remained; the remnant being deemed too unsafe to occlude by means of embolization. Seven patients had residual AVM left after microsurgery for similar reasons. In cases of prior treatment (microsurgery or embolization), radiosurgery was administered only to regions of persistent pathologic blood flow on pre-radiosurgical angiograms.

Radiosurgical technique

A technical description of CyberKnife radiosurgery for spinal AVMs has previously been described [12]. In brief, all patients underwent repeat high-resolution MRI, CT angiography, and conventional selective spinal angiography to ascertain precise nidal volumes and establish their relationship with nearby skeletal landmarks.  In the earliest years of this study, percutaneously-placed fiducial markers, utilized in the process of radiosurgical targeting, were surgically inserted prior to such imaging. Three-dimensional rotational angiography (3D DSA) was used routinely beginning in 2004. Qualitatively, such imaging provided superior identification of the AVM nidus separate from the adjacent draining veins [14]. Unsubtracted projection images from angiographic runs provided valuable clues to the spatial relationship between the AVM and adjacent skeletal landmarks. Of note, it was not technically possible, over the course of this series, to fuse time-dependent angiographic projection images (from 3D DSA) with the 3-D volumetric images. Actual target delineation took place on a combined data set (CT, MRI and the full 3D DSA volume) generated with semi-automated image fusion. 

Treatment plans were generated with the CyberKnife inverse planning software seeking to optimize radiation dose conformality, while maximally sparing adjacent neural structures. Planning was an iterative process utilizing both qualitative assessments of conformality and a more quantitative analysis involving dose-volume histograms. 

Following image-guided registration, radiosurgery was administered using standard CyberKnife procedures to awake, unanesthetized patients [12]. Partial immobilization was achieved with either an Aquaplast mask or alpha cradle mold depending on the spinal location being treated. Treatment times ranged between 40 to 90 minutes. After each radiosurgical session, patients were given 4 mg of dexamethasone to prevent the exacerbation of adjacent spinal cord edema, and for some upper cervical lesions, anti-nausea medications were also administered.

Radiosurgical dosage

The selection of radiation dose throughout this series was the product of a complex calculus that drew upon an extensive radiosurgical experience with cerebral AVMs in critical deep brain regions [15], and later on, a growing understanding of the risks and benefits of using different doses to manage a range of intra- and extra-axial vascular and non-vascular spinal lesions [16]. At the initiation of this study, there was no prior experience with treating spinal lesions with radiosurgery. Primarily out of fear of inducing catastrophic spinal cord injury in oftentimes highly functional young patients, our initial dosing was deliberately quite conservative. To achieve this objective, a multi-session approach to radiosurgery was often employed, despite simultaneously recognizing that from standpoint of radiobiology, the use of fractionation to ablate AVMs may well be a self-defeating proposition [12, 17].

In comparing different fractionation regimens, conventional fractionated radiotherapy was used as a benchmark. From the linear quadratic model, a biologic equivalent dose (BED) can be estimated from the following formula: BED = nd(1 + d/(α* β)) [18]. Assuming an α-to-β ratio of 2 Gy, multisession radiosurgical regimes were devised to gradually approach a BED comparable to a single session of 15 Gy which at the low end of dose used to treat some intracranial AVMs in critical locations; such a dose yields approximately a 70% rate of in-field obliteration for intracranial AVMs [19].

The final fractionation schedule (ranging over the course of the study between one to four sessions, with a median of two) was also customized to reflect AVM volume and spinal location. In the name of patient safety, dose selection repeatedly erred on the side of conservatism. Only gradually was the amount of radiation increased, largely by de-escalating the number of radiosurgical sessions. Prescription doses ranged between the 70 and 90% isodose contour lines and were defined at the margin of the AVM nidus.

Follow-up evaluations

Clinical and radiographic evaluations were conducted at six months, one year, and annually thereafter. Patients were instructed that in the event they experienced any acute neurological deterioration they were to promptly contact us or their referring physician who in turn might communicate to us any pertinent information.  In this regard, hemorrhage was defined as a clinically symptomatic event (sudden onset of pain, focal deficit, gait disturbance, genitourinary dysfunction, or combination of these) along with signs of fresh bleeding detected by means of CT or MRI. At six months and annually following radiosurgery, every patient underwent spinal MRI; at three years, spinal angiography was repeated. Angiographic obliteration was defined as the absence of abnormal vessels at the site of the original malformation, the disappearance or normalization of draining veins in and around the nidal region and a normal circulation time on angiography [20]. Neuroradiologists and neurosurgeons made independent determinations of AVM obliteration but with full knowledge of patients’ histories.

AVM volume was estimated on two-dimensional angiograms by measuring nidal diameter in three orthogonal planes. This crude volume approximation utilized the formula for an idealized ellipsoid:  V = 4/3(π r1 r2 r3), where r1, r2, and r3 denote the radius of the three cardinal planes. When three-dimensional angiography was performed, volumetric assessments were improved by being able to sum the cross-sectional areas of adjacent parallel slices.  The validity of estimating AVM volume on projection angiography was semi-quantitatively corroborated in five patients who had both pre- and post 3D angiograms in addition to 2D studies.

If a SCAVM was not occluded on angiography, patients were asked to undergo repeated angiography 12 - 24 months later, or when an annual MRI suggested obliteration. In selected patients with residual AVM at five years post-radiosurgery, a second CyberKnife treatment was recommended.  This was particularly pertinent for the earliest patients in this series to whom the most conservative radiation doses were prescribed. Of note, clinical follow-up continued even after total obliteration. 

Information on all patients was prospectively entered into a computer database at the time of radiosugery and during subsequent clinic visits. The dates of diagnosis, radiosurgery, previous and additional hemorrhage, angiographic obliteration status, and last clinical follow-up were included in the analyses, along with data on the initial clinical presentation and treatment history. The observation period was divided into: the interval between symptom onset and radiosurgery, the interval between radiosurgery and angiographic obliteration, and the interval from angiographic obliteration to last clinical follow-up. The ascertainment of a hemorrhagic presentation prior to radiosurgery was determined by a history of acute onset of pain and/or focal symptoms with evidence of hemorrhage on MRI, lumbar puncture, or at surgery. In addition, one patient provided such a compelling history involving the single acute onset of pain and hemiparesis, more than ten years prior to his ultimate AVM diagnosis, that a bleeding history was inferred. Three more patients with radiographic evidence of multiple hemorrhagic events also provided similar compelling histories of additional bleeds prior to diagnosis.

Statistical analysis

A time-dependent Cox proportional-hazards model and SPSS software version 14 were used to analyze the effect of radiosurgery on the incidence of hemorrhage [21-22]. Two sets of time-dependent covariates were defined: -1 for the period before radiosurgery and 1 for the period after radiosurgery. The primary endpoint was hemorrhage-free survival. Data on patients prior to radiosurgery was censored at the time of treatment. Patients were censored within the post-radiosurgical bleeding risk group when either the AVM obliterated or at last clinical follow-up. One patient had nearly 95% of her AVM ablated at five years and underwent embolization to obliterate the residual, and was censored at that time.  In the overall analysis, patients were also divided into two groups: those initially presenting either with, or without, a prior history of hemorrhage. Next in this analysis, hemorrhage was included as a fixed covariate at the time of initial clinical presentation. To compare the results of these two models, we used the likelihood ratio test to detect interactions between a history of prior hemorrhage and time-dependent covariates.

The reduction in the incidence of hemorrhage in the period after radiosurgery was calculated as 100 x (1 – hazard ratio). A two-sided P-value of less than 0.05 was considered to indicate statistical significance. The annual hemorrhage rate was calculated as the number of hemorrhages divided by the aggregate of the all observation periods. The cumulative rate of obliteration was calculated according to the Kaplan-Meier method [23]

Results

Thirty-three patients with intramedullary spinal cord AVMs were evaluated for inclusion in this study. From within this group, three conservatively followed asymptomatic patients were excluded. Therefore, 30 patients (17 women, 13 men; median age 33 years; range, 9-55) met treatment criteria and underwent CyberKnife radiosurgical ablation of their AVMs (Table 1). Malformations were situated throughout the entire spinal axis; 18 lesions were located in the cervical region of the spinal cord, nine in the thoracic, and three in the conus medullaris. All but one AVM was angiographically consistent with the Type II glomus categorization of spinal cord  AVM; the outlier was a Type III thoracic level metameric lesion that included a substantial intramedullary component.

Patient demographics
Male/female 13/17
Location (Cervical/Thoracic/Conus) 18/9/3
Age at radiosurgery (median, range) 33.0 years, (18-55 years)
Time from diagnosis to radiosurgery (mean, range) 8.3 years, (0.2-22 years)
Prior treatment modalities
Embolization 11
Surgical resection 6
Repeat CyberKnife procedures 4

Presenting symptoms varied with anatomic location in the spinal cord (Table 2). Seventeen patients presented with or had a history of hemorrhage, while pain, vascular steal, or venous congestion caused the presenting symptoms among the remaining cases.  Several patients (44%), especially in the earliest years of this series, had undergone a previous intervention with either embolization (11 patients) and/or surgery (six patients); none underwent prior irradiation. 

Presenting Symptoms Number (%)
Hemorrhage 16 (57%)
Steal (Transient Neurologic Symptoms) 2 (7.4%)
Pain 8 (30%)
Weakness 16 (59%)
Sensory Loss 13 (48%)
Bladder/Bowel Paresis 6 (22%)
Gait Abnormalities 11 (41%)

The mean time from initial diagnosis to CyberKnife radiosurgery was 8.3 years (range, 0.2 - 22). Given the rarity of spinal cord AVM, it is not surprising that many of our patients were referred nationally or internationally. No mortality was observed, and no patient was lost to follow-up.

Angiographic response to CyberKnife radiosurgery

Radiographic response to radiosurgery was ascertained routinely at three years with digital subtraction angiography unless serial MRI suggested earlier obliteration (two patients). The mean clinical and radiographic follow-up after radiosurgery for the entire series was 63 months (median, 54; range, 11 - 145) and 54 months (mean 53; range, 6 - 145), respectively. Twenty-seven patients had follow-up greater than 24 months (seven, > seven years; 11, > six years; 11, > five years; 20, >four years; 22, >three years); mean follow up in this group was 66 months (median, 56; range, 24-145). All but four of the 22 patients with greater than three year follow-up, underwent post-treatment conventional spinal angiography to determine the obliteration status of their AVM. Two such patients refused to undergo angiography; one of whom had a CT angiogram that clearly demonstrated residual, albeit a smaller, AVM, while in second patient flow voids were still visible on MRI. The two remaining patients have angiograms scheduled, but were not completed by the time of this writing.

Six of 22 patients who were more than three years from a single radiosurgical treatment had complete angiographic obliteration of their AVMs; complete obliteration was defined as no residual nidus or evidence of early venous drainage. The three-year rate of radiosurgical obliteration was therefore 27%. Meanwhile, there was a partial response to radiosurgery in 14 lesions, defined as any reduction in nidal volume greater than 25%, but less than complete obliteration. Within this group, five patients experienced a near complete reduction of nidal volume between 76-95%, five patients had between 51-75%, and in four cases, the decrease in volume was only 25-50%. Any patient in whom the reduction in nidal volume was less than 25% at three years after radiosurgery was classified as a non-responder (one patient). One patient awaits angiography but had evidence of AVM volume reduction on MRI at two years. These data are summarized in Figure 3. Representative cases are discussed in Figures 4-5.

No correlation was identified between patient or AVM characteristics and angiographic response to radiosurgery. Despite an expected relationship between AVM volume and angiographic response, none was observed (Figure 6). No correlation was found between spinal cord location and the likelihood of angiographic obliteration (Figure 6). Neither could any relationship be demonstrated between AVM obliteration and patient age, gender, nor prior AVM treatment (not shown). 

Radiosurgical dosage and fractionation

Table 3 summarizes the most relevant radiosurgical parameters used in this series. The target volumes ranged from 0.150 to 15.0 cm3 (mean 2.79 cm3; median 1.70 cm3). Treatment plans were designed to deliver between 1600 to 2550 cGy to an average 78th percentile isodose line as defined at the margin of the treated AVM. The corresponding maximal intra-lesional dosage ranged from 1190 to 3000 cGy (mean 2500 cGy). Similar radiosurgical doses were utilized throughout all three regions of the spinal cord. 

# of Sessions Total Dose (Gy) Prescription Isodose BED (Gy) Single-dose Equivalent (Gy)
3 16.0 71 58.67 9.88
1 16.0 71 144.00 16.00
1 18.0 75 180.00 18.00
2 20.0 75 120.00 14.52
4 21.0 70 76.13 11.38
2 20.0 86 120.00 14.52
3 21.0 80 94.50 12.78
2 20.0 80 120.0 14.52
2 20.0 77 120.0 14.52
2 18.0 75 99.00 13.11
3 20.0 80 86.67 12.20
2 20.0 68 120.00 14.52
3 21.0 90 94.50 12.78
3 20.0 70 86.67 12.20
3 20.0 98 120.0 14.52
3 21.0 80 94.50 12.78
3 20.0 74 86.67 12.20
3 18.0 85 72.00 11.04
2 20.0 81 120.00 14.52
2 15.0 85 71.25 10.98
2 20.0 68 120.00 14.52
3 20.0 84 86.67 12.20
3 21.0 86 94.50 12.78

For small to moderate sized intracranial AVMs, it is generally accepted that the optimal single radiosurgical dose ranges from 18 to 24 Gy depending on the location of the lesion [24-26]. The choice of dose in this series was an ad hoc decision, drawing from our extensive experience treating AVMs in the brainstem, deep nuclei (38), and extra/intramedullary spinal tumors [16]. Especially early on, a multi-session approach was used to mitigate some of the risk of radiation-induced myelopathy.  With experience, we were able to gradually reduce the number of sessions, thereby increasing the prescribed single dose equivalent (Figure 6a).

Our first patient was treated with 21 Gy in four sessions (single dose equivalent of about 10 Gy) in 1997, after which the dose was gradually increased to 20 Gy in two sessions, first used in 2002. The single fraction equivalent of this dose is 14.5 Gy, a value that approximates our original dose objective. As we gained greater confidence, two smaller spinal cord AVMs were even treated in recent years using a single session. The most common radiosurgical regimen involved either two (45%) or three (41%) sessions. Despite our pre-existing assumption that dose would correlate with the obliteration response, no significant correlation (r2 = 0.256) could be demonstrated between BED and the overall angiographic response (Figure 6b). Nevertheless, it is notable that the six AVMs that were totally obliterated were all treated after 2002, and four of these were treated after 2005, a time scale which roughly correlates with an increase in radiosurgical dose. 

Repeat radiosurgery

Four patients with incomplete responses at three (two patients), four, and five years from a first radiosurgical treatment were retreated (Figure 7). 

Two of the four re-treated AVMs have since gone on to obliterate their AVMs bringing the total number of patients with complete eradication to eight. One patient, the first in this series (1997), who had her C3 AVM treated with a very conservative dose (in hindsight) of 2100 cGy in four sessions. At three years over 50% of this patient’s AVM remained, a size that did not change over the ensuing year. Eight years after being retreated with 1500 cGy in two sessions, follow-up angiography revealed no evidence of residual malformation. Similarly, a second patient, first treated in 2001 for a 1.56 cm3 C3 AVM with 2100 cGy in three sessions, had a 50% decrease in AVM size on follow-up angiography at 4.5 years. At this juncture, the patient was retreated with 1800 cGy in two sessions. A final angiogram four years later revealed complete occlusion. Two other retreated patients await angiographic follow-up, one of whom has a recent MRI that demonstrates the absence of flow voids and signal characteristics consistent with obliteration.

Effects of radiosurgery on clinical symptoms

The small sample size for various symptoms precluded anything except a qualitative assessment. After radiosurgery, most clinical symptoms either remained stable or improved (Figure 8); by 12 months, most patients reported improvement of at least one pre-radiosurgical symptom. Clinical benefits seemed to correlate temporally with a decrease in AVM size and blood flow. At three years of follow-up, a time at which 90% of AVMs were reduced in size, the most common benefits related to gait ataxia (70%), myelopathic weakness (50%), and pain (50%). The likelihood of improvement in neuropathic pain was significantly higher in this series than previously reported after surgical resection [11, 27]. This difference could reflect the inevitable consequences of separating the posterior columns as is needed to achieve a surgical corridor during microsurgical resection.

Outcomes in patients with neurological deficits not associated with hemorrhage

It is has been generally observed that many patients experience improvement in their symptoms within the first year following hemorrhage [3]. Several factors contribute to this phenomenon, including absorption of the hematoma, resolution of edema, increased cord perfusion, and abatement of any inflammatory response. In an effort to understand if there exists any direct clinical benefit from AVM obliteration without a confounding prior history of hemorrhage, outcome was stratified to include a cohort of unruptured spinal cord lesions. Forty-three percent of patients in this study (13 patients) presented with neurological symptoms without evidence of bleeding. In order of decreased frequency, those symptoms were myelopathic weakness (77%), axial sensory loss (69%), gait dysfunction (62%), neuropathic pain (46%), and bowel/bladder dysfunction (46%). Symptom improvement, when observed, occurred gradually between six - 24 months. Seventy percent of the non-hemorrhagic patients with weakness and gait disturbance had evidence of benefit following radiosurgery. Pain was also subjectively reported improved in over two-thirds of those with this complaint. The overwhelming majority of patients (80 - 90%) with dysesthesia and genitourinary dysfunction reported no change or slight improvement in these problems. A single patient in this cohort experienced an increase in weakness, while one other complained of a worsened gait. All thirteen patients in this non-hemorrhagic group demonstrated some radiographic response to radiosurgery by two years; on angiography, three patients had complete AVM obliteration, and three had an 80% or greater reduction in size.

Outcomes in patients with hemorrhagic presentation

Seven of the seventeen patients with history of AVM bleeding underwent either embolization or microsurgery prior to referral, two of which suffered bleeding events between their last intervention and radiosurgery. Six of seventeen patients received radiosurgery within one year of their last hemorrhage. The mean time between the last bleed and CyberKnife radiosurgery for the entire group was 5.7 years (median, 1.5). Two-year follow-up was available in fifteen of patients in this cohort. When compared to the non-hemorrhagic group, patients with a history of AVM bleed were equally likely to present with weakness (82%), numbness (76%), and pain (47%), but less likely to complain of gait ataxia (35%), or bowel/bladder dysfunction (18%). Approximately 50% of post-hemorrhage patients had no change in their symptoms following radiosurgery, while about one-third reported benefits. Meanwhile, three patients had increased weakness, sensory loss, or neuropathic pain. Among the 12 (out of 17) patients who underwent three-year angiographic follow-up, three had complete AVM obliteration, eight had a partial angiographic response, and one did not respond at all.

Rate of hemorrhage before and after radiosurgery

Seventeen patients (57%) presented with a prior history of AVM bleed, and in over 50%, there were multiple hemorrhages (Figure 2). Three of the seventeen patients presented with other symptoms before suffering a bleed. Despite a history of hemorrhage, intra-nidal aneurysms were observed on angiography in only a minority of cases. 

Assuming that the probability of an AVM bleed is linear from the time of first presentation, an annual rate of hemorrhage prior to radiosurgery was estimated by dividing the number of hemorrhages by the sum of the observation period. Among the seventeen patients that bled, 31 pre-radiosurgical hemorrhages were recorded; nine patients had at least two bleeds, three had at least three, and two had four episodes of bleeding. Meanwhile, a total of 305.76 patient years elapsed throughout the entire series (30 cases) between diagnosis and radiosurgery. Given the above values, the retrospectively estimated annual rate of hemorrhage was calculated to be 10% per patient-year. In contrast, the annual hemorrhage rate prior to treatment in the cohort with a history of hemorrhage was similarly determined to be 17% per patient-year. When normalized to the initial “index” hemorrhage, the mean duration to re-hemorrhage, which occurred in nine patients, was 5.3 years (median, 3.33).

It is widely assumed that persistence of any AVM nidus on angiography is associated with a risk of future hemorrhage that is little changed from the natural history of an untreated lesion. In other words, only complete obliteration or resection is protective. Despite this general belief, no rebleeding was observed among any of the partially obliterated spinal cord AVMs in the current study, after a mean 5.4 years (median, 4.5) of post-radiosurgical follow-up (Figure 9). Based on this analysis, it appears that CyberKnife radiosurgery reduced the risk of AVM bleeding among this entire series of patients. The decrease in risk was even greater among the 17 patients who presented with a history of hemorrhage.

Neurological deterioration post-radiosurgery

Three patients experienced worsening of their symptoms following CyberKnife radiosurgery. The only direct treatment related complication occurred in a 19 year-old woman with a cervico-thoracic junction AVM, who developed worsening hemiparesis nine months after radiosurgery. In this presumptive case of radiation injury, the total prescribed dose was 2000 cGy administered over two sessions to a lesion volume of 1.57 cm3, using a maximum dose of 2667 cGy. Radiosurgical volume and other treatment parameters in this case were similar to those used for other patients in this series. MRI revealed increased T2 weighted signal within the adjacent spinal cord and other imaging characteristics consistent with radiation-induced myelopathy (Figure 10); meanwhile, angiography demonstrated a greater than 90% reduction, but not complete obliteration, in AVM nidal volume. 

Post-treatment neurological dysfunction was also observed in a 30-year-old man with a T12 glomus AVM who suffered from progressive lower extremity weakness and sensory dysfunction.  He underwent CyberKnife SRS in two sessions to a total marginal dose of 2000 cGy. During the second of two sessions (2 x 10 Gy, total 20 Gy), he developed an acute flaccid paraparesis.  Immediate MRI did not demonstrate hemorrhage or radiation injury. Although the mechanism for such an acute neurological change remains unclear, the patient made a gradual recovery over the ensuing 18 months. At the last follow-up, significant deficits persist but the patient was able to walk without assistance. Angiography at three years confirmed AVM obliteration.

The third patient who suffered neurologic deterioration after radiosurgery is a 35 -year-old woman with a history of multiple hemorrhages from a C5/6 AVM who developed worsening leg weakness, despite prior partial AVM embolization. Three radiosurgical sessions were administered to a total marginal dose of 1800 cGy, as defined at the 85% isodose line. CyberKnife radiosurgery was repeated at three years because of persistent leg symptoms and a 50% residual AVM nidus. For this second treatment, a marginal prescription dose of 2100 cGy in three sessions, at the 71% isodose line was utilized. Despite re-treatment, her leg weakness continued to progress, and was eventually accompanied by urinary retention. An MRI done three years after the second course of radiosurgery revealed disappearance of intramedullary flow voids but no explanation for the new neurologic symptoms. Follow-up angiography is scheduled.

Discussion

Determining the efficacy of an innovative treatment for a rare insidious medical condition with a poorly understood natural history is often a vexing problem.  Nevertheless, when there exists the looming possibility of an uncertain but serious injury if the disease is left untreated, physicians are pushed towards some type of intervention. However, in doing so, the underlying natural history is never revealed. Such is the case for stereotactic radiosurgery for spinal cord arteriovenous malformations (SCAVMs), where low event rates (hemorrhages), slow treatment effects, and small numbers of patients, all collectively conspire against the unambiguous demonstration of treatment benefit. Furthermore, despite an uncertain natural history, it is difficult to stay one’s surgical instincts in the setting of such a potentially catastrophic neurologic disorder. It was under this scenario that the senior author first began to use CyberKnife radiosurgery to manage spinal cord AVMs in 1996.

The use of CyberKnife radiosurgery to ablate high risk and generally untreatable diffuse intramedullary SCAVMs represented a logical extension of the approach developed for deep intracranial arteriovenous malformations.  In this study, which notably utilized the most conservative of radiosurgical doses, we report a three-year angiographic obliteration rate of over 27%, a response rate of over 95%, and a complication rate of less than 10%. These results demonstrate that CyberKnife radiosurgery can be an effective and safe option for many SCAVM.

The overall obliteration rate we observed is significantly below what has been described for intracranial AVMs, which at three to five years has been reported to be as high as 80 to 90% for malformations less than 3 cm in diameter [24-25]. However, the radiosurgical doses prescribed in these studies were as much as 12 Gy more than those employed for SCAVMs in the current series.  It should be noted that the treatment of thousands of brain AVMs was required to arrive at these seemingly optimal present day radiosurgery treatment parameters and corresponding clinical outcomes. Therefore, it would seem likely that still further experience, beyond that which we now report, will be needed to determine the ideal prescription dose for SCAVM.  Unfortunately, given the rarity of these lesions, it could take considerable time to acquire the requisite experience. 

Despite the modest number of cases in the current study, it is one of the largest series of SCAVM patients undergoing any type of treatment. Among the largest experiences, Spetzler, et al. described the post-microsurgical outcome in 27 patients with intramedullary and 17 conus AVMs; resection was complete in 92% of cases and 53% were improved following surgery [10].  Meanwhile, Berenstein and Lasjaunias detail their experience with 44 SCAVMs treated with endovascular embolization. In this series, 53% of patients had a complete obliteration of their AVM. Although the overall clinical outcome was reported as good or excellent in 77% of patients, a complication rate of 11% was encountered [3].

The published experience with any type of radiation treatment for SCAVM is quite limited, consisting of one clinical series [28] and a few single case reports [29-30]. Hida, et al. described a series of 10 patients with SCAVMs who were treated with hypofractionated LINAC stereotactic radiotherapy [16]. The prescription dose varied between 32 Gy in 18 fractions (1.8 Gy/day) to 40 Gy in 20 fractions (2 Gy/day) in most patients; one patient received 3.75 Gy/day for eight days (30 Gy), and two patients received 5 Gy/day for four days (20 Gy). The single fraction equivalent dose to this variety of radiation therapy treatments would range between 10 to 12 Gy, which is substantially less than our initially targeted dosage in the current study. While complete AVM obliteration was not observed after stereotactic radiotherapy, five patients had a partial volume reduction of the nidus on angiography, over a median of 49 months. Given what is known about the dose responsiveness of cerebral AVMs after radiosurgery, it is reasonable to surmise that the same biologic phenomenon explains the marked differences in AVM volume reduction noted between Hida et. al. [16] and the radiosurgical experience we now report.   

As argued above, it would seem probable that the extent of shrinkage and the likelihood of spinal cord AVM obliteration are directly related to radiosurgical dose. Despite this seemingly well-founded argument, we were unable to demonstrate such an effect in this series. In large part, this may simply be an artifact that results from the small number of patients that were treated and heterogeneity of the study cohort. In addition, the relatively conservative doses utilized to date may still be situated on “the flat” low dose part of the radiosurgical dose response curve.

Our incomplete knowledge of the radiation tolerance of normal spinal cord was a major influence in our selection of radiation dose. Based on the clinical observations with patients undergoing radiotherapy for head and neck cancers, the dose tolerance of the cervical spinal cord is believed to be 50 Gy when using conventional fractionation [31]. However, because BED formulations are much less accurate when comparing hypofractionated regimens, it is unclear how to directly translate standard radiotherapy dosing to radiosurgical practice. Since (fortunately) only one patient in this series suffered a complication on a time scale that one might expect from a delayed radiation-induced injury, it is impossible to arrive at firm conclusions about the upper radiation dose limit for normal spinal cord. Nevertheless, the fact that there was only one such apparent injury provides a reasonable rationale for further dose escalation, perhaps especially in patients with the smallest SCAVMs? Despite our still modest understanding of radiation injury thresholds, our current experience, including the small number of SCAVM cases who underwent two separate radiosurgical treatments, clearly demonstrates that conventional teaching underestimates the radiation tolerance of the spinal cord; repair of sub-lethal damage may be a much more potent influence than previously recognized.

Estimates of the rate of cerebral AVM hemorrhage vary significantly depending on whether the analysis aims to report the cumulative or per annum risk [32-35], and the inclusion of recurrent and previous hemorrhages [7]. Given their relative rarity, confusion among classification systems [10], and the small number of modern clinical series with any natural history data, it is even more difficult to estimate the innate rate of bleeding for SCAVM. Shephard reports a series “intradural AVM” where 39 hemorrhages were observed in 35 patients over a mean 8.5 year interval prior to surgical resection [5]. In this retrospective study, the annual rate of SCAVM hemorrhage among all patients was 13% per patient year, and 17% per patient year in the cohort of 22 patients with a history of hemorrhage. Interestingly, this compares similarly to what was observed in the current series; the rate of rebleed over a mean 8.3 years prior to radiosurgery was 10 and 17% among the two different categories of SCAVM. Notably, both values are considerably higher than the approximate 2.4% per year annual hemorrhage rate for intracranial AVM [36].

Despite incomplete SCAVM obliteration, we observed a significantly decreased risk of hemorrhage after radiosurgery. Previous studies on intracranial AVMs have reported that the risk of hemorrhage during the latency period decrease [37-38], remains unchanged [36, 39], or even increases [15, 40] when compared with the natural course of the disease. Of note, these prior cerebral AVM studies tended to compare the risk of hemorrhage among selected patients who underwent radiosurgery with patients who did not undergo radiosurgery; in contrast, the present series analyzed changes in the rate of hemorrhage pre- and post-radiosurgery. Our findings appear to mirror those reported for intracranial AVMs by Maruyama, et al. [26]. Interestingly, the only other series of SCAVMs treated with radiation also observed a zero rate of hemorrhage among ten patients with non-obliterated lesions followed for at least four years [28].

The traditional belief has been that persistent AVM nidus following radiosurgery portends a hemorrhage risk equivalent to an untreated lesson [41-43]. The fact that no further hemorrhage was observed among treated but non-obliterated AVM in the current series is at odds with this tenet. Although a protective effect of radiosurgery in the absence of obliteration could be artifactual, explained by the small sample population, a relatively brief post-radiosurgery observation interval, or a more benign natural history of SCAVM than previously believed, it could also be a real phenomenon, as best described by Maruyama [26]. Although the sample size is small, the fact that the improvement in clinical symptoms was more prevalent in patients without prior history of hemorrhage, as compared to those with such a bleeding history, may suggest that spinal cord damaged by bleeding tends to recover less well than nervous tissue compromised by mass effect and steal. Hopefully, future studies can examine this finding in greater depth.

Conclusions

What is the exact role of radiosurgery when multimodal treatment options for SCAVM are available? This question is particularly pertinent to incompletely obliterated lesions as is illustrated by our patient who 5.4 years following 95% radiosurgical ablation of her thoracic AVM, underwent complete obliteration by means of endovascular embolization. Of note, multiple prior embolization attempts in this patient had been unsuccessful. Moreover, it is unclear whether or not repeat radiosurgery, which was never considered, might have achieved the same definitive outcome in such a case. It is probable that centers which provide surgery, endovascular therapy, and radiosurgery for SCAVMs, will find that similar to brain lesions, a multimodality paradigm is sometimes superior to an approach using any one treatment alone. However, as demonstrated by this paper, a primary radiosurgical approach is often a safe and effective tool for treating most SCAVM. Despite our favorable single institutional experience, a prospective multi-institutional trial, which includes stricter definitions for radiosurgical planning and spinal cord morbidity, is needed to further validate our proposed strategy for managing SCAVMs. In particular, still longer term follow-up is required to validate the safety of radiosurgery for intrinsic spinal cord lesions.


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Original article
peer-reviewed

CyberKnife Ablation for Intramedullary Spinal Cord Arteriovenous Malformations (AVMs): A Promising New Therapeutic Approach


Author Information

John R. Adler Jr. Corresponding Author

Radiation Oncology, Stanford University Medical Center, Stanford, USA

Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA

Gaurav Gupta

Department of Neurosurgery, Stanford University School of Medicine

Steven D. Chang

Department of Neurosurgery, Stanford University School of Medicine, Stanford, USA

Scott G. Soltys

Department of Radiation Oncology, Stanford University School of Medicine, Stanford, USA

Iris C. Gibbs

Department of Radiation Oncology, Stanford University School of Medicine, Stanford, USA

Gary K. Steinberg

Stanford University School of Medicine

Michael B. Edwards

Department of Neurosurgery, Stanford University School of Medicine


Ethics Statement and Conflict of Interest Disclosures

Human subjects: Consent was obtained by all participants in this study. The Stanford University Institutional Review Board issued approval N/A. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: John Adler declare(s) an alternate financial activity from Accuray, Inc. Shareholder. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.


Original article
peer-reviewed

CyberKnife Ablation for Intramedullary Spinal Cord Arteriovenous Malformations (AVMs): A Promising New Therapeutic Approach


Figures etc.

Original article
peer-reviewed

CyberKnife Ablation for Intramedullary Spinal Cord Arteriovenous Malformations (AVMs): A Promising New Therapeutic Approach


Patient Reported Outcome

Patient name: Broer Oatis

I’ve undergone two rounds of CyberKnife surgery to treat a spinal cord arteriovenous malformation (AVM) that twice bled (or hemorrhaged). Each bleed resulted in relatively significant physical deficits, including partial paralysis. Nine years after receiving CyberKnife and 17 years after my first bleed, I am writing this report as a healthy and active 27 year-old law student.

Though the treatments have not yet completely obliterated my AVM, they have substantially reduced its size, and I have not experienced a bleed since receiving the first treatment. Apparently, CyberKnife protects against future bleeds even when it does not result in a complete cure. I am still hopeful that the second treatment will continue to reduce the size of my AVM and eventually lead to obliteration. The treatment is not without risks, and I may have experienced a negative side effect: a few months after my second round of CyberKnife, I noticed a slight numbness in my left hand that persists today. I’m not sure if this minor numbness was caused by the second treatment or is an injury stemming from repetitive stress from typing and poor computer posture. Overall, I consider CyberKnife the single most important factor in enabling my current able-bodied existence and my belief in a future free from bleeds.

I was first diagnosed with a cervical spine AVM at the age of 11 when it bled in the fall of my fifth grade year. I had a fever, nausea, severe neck pain, left sided muscle weaknesses, coordination problems, affected gait, and host of other neurological symptoms. After being flown across the country for an evaluation by a team of specialists, it was determined that conventional surgery to fix my AVM unduly risked permanent injury. In line with the specialists’ advice, my parents and I decided that just living with my condition and hoping for the best was the wisest course of action.

Over the next few months I recovered fully. I remember being concerned about the possibility of future bleeds but also relatively accepting of my situation as I imagine many children are who develop childhood illnesses. 

My AVM bled again my senior year of high school. Again physical deficits, again a cross-country trip for evaluation, another decision to forego conventional surgery, and another long but steady recovery. At that time I resolved myself to a life of intermittent bleeds. Though I had, and was correct in having, an expectation of full recovery from my second bleed, I also knew that neuroplasticity reduces with age and that a large bleed later in life carried a high risk of permanent disability and possibly even death. 

The summer after my second bleed, I attended physical and occupational therapy regularly and prepared for my first year of college. 

Connecting with the CyberKnife team was pure coincidence. I was enrolling as a freshman when a neurologist at Stanford that I had met with regarding my condition recommended a new method of treatment being used at Stanford for my illness. I believe I was in the first round of 20 or so patients to be treated for spinal AVMs with CyberKnife. 

There isn’t much to say about the surgery itself. It is painless and easy. I wore my normal clothes and was laid on a bed with my face held in place by a mesh mask to keep my head and spine from moving.  For an hour or so a robotic arm moved quietly about sending doses of radiation through my neck. Classical music played in the background. It was surreal. I was told that over the next few years the radiation would cause the nidus of the AVM to shrink and die away. The hardest part was undergoing an angiogram prior to the CyberKnife treatment; this was necessary in order to map the structure of the AVM and enable the robot to target the precise malformed arteries and veins without damaging the surrounding spinal cord. (An angiogram involves a relatively large catheter being put into an artery in one’s groin. The puncture wound is tender for a few days.)

Six years after that first treatment, my AVM had shrunk to about one quarter of its original size. At that point I underwent a second round of surgery in the hopes that the AVM would be reduced even further if not fully destroyed. I am told that conservative dosages of radiation were used in initial treatments due to the newness of the therapy, which made me a good candidate for subsequent treatment. I am still waiting for the final results of the second surgery, but I am under the impression that my outcome so far has been relatively typical. 

So here I am today. I play my cello, as I have since the age of three, both hands working as well as can be expected with the amount of time I devote to practicing – both hands which at separate times had not been able to do the most basic cello actions, like holding a bow. I walk and run without any weakness or limp. During the summer, I ride my bike twenty miles a day to commute to work. I rock climb with friends on weeklong backpacking trips. During the winter, I ski and play squash with classmates at school. Given all that has happened, and even though a medical examination still elicits some symptoms of a neurological injury, I am extremely happy with my physical condition and the results of CyberKnife treatment.

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