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Case report
peer-reviewed

A Myth Still Needs to be Clarified: A Case Report of the Frank's Sign



Abstract

Despite advancements in diagnostic tools, physical signs such as xanthelasmata, arcus corneae, facial wrinkles, and gray hair are useful indicators of underlying diseases. The presence of bilateral diagonal earlobe creases (DELCs), also known as Frank’s sign, correlates with a myriad of cardiovascular diseases such as coronary artery disease, cerebrovascular disease, and peripheral vascular disease. The use of Frank’s sign as a bedside predictor of underlying coronary artery disease is controversial among clinicians. We report a case of a patient with bilateral DELCs found to have significant coronary artery disease during diagnostic coronary angiography for recurrent chest pain.



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Case report
peer-reviewed

A Myth Still Needs to be Clarified: A Case Report of the Frank's Sign


Author Information

Aung Naing Lin Corresponding Author

Internal Medicine, The Brooklyn Hospital Center

Kyawzaw Lin

Medicine, The Brooklyn Hospital Center

Htoo Kyaw

Cardiology Department, the Brooklyn Hospital Center, Cardiology Fellow of the Brooklyn Hospital Center, Affiliate of the Mount Sinai Hospital. 121, Dekalb Avenue,brooklyn, Ny 11201

Joseph Abboud

Cardiology Department,the Brooklyn Hospital Center, Cardiology Attending of the Brooklyn Hospital Center, Affiliate of the Mount Sinai Hospital. 121, Dekalb Avenue,brooklyn, Ny 11201


Ethics Statement and Conflict of Interest Disclosures

Human subjects: Consent was obtained by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.


Case report
peer-reviewed

A Myth Still Needs to be Clarified: A Case Report of the Frank's Sign


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Case report
peer-reviewed

A Myth Still Needs to be Clarified: A Case Report of the Frank's Sign

  • Author Information
    Aung Naing Lin Corresponding Author

    Internal Medicine, The Brooklyn Hospital Center

    Kyawzaw Lin

    Medicine, The Brooklyn Hospital Center

    Htoo Kyaw

    Cardiology Department, the Brooklyn Hospital Center, Cardiology Fellow of the Brooklyn Hospital Center, Affiliate of the Mount Sinai Hospital. 121, Dekalb Avenue,brooklyn, Ny 11201

    Joseph Abboud

    Cardiology Department,the Brooklyn Hospital Center, Cardiology Attending of the Brooklyn Hospital Center, Affiliate of the Mount Sinai Hospital. 121, Dekalb Avenue,brooklyn, Ny 11201


    Ethics Statement and Conflict of Interest Disclosures

    Human subjects: Consent was obtained by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

    Acknowledgements


    Article Information

    Published: January 17, 2018

    DOI

    10.7759/cureus.2080

    Cite this article as:

    Lin A, Lin K, Kyaw H, et al. (January 17, 2018) A Myth Still Needs to be Clarified: A Case Report of the Frank's Sign. Cureus 10(1): e2080. doi:10.7759/cureus.2080

    Publication history

    Received by Cureus: January 03, 2018
    Peer review began: January 13, 2018
    Peer review concluded: January 15, 2018
    Published: January 17, 2018

    Copyright

    © Copyright 2018
    Lin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 3.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

    License

    This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Despite advancements in diagnostic tools, physical signs such as xanthelasmata, arcus corneae, facial wrinkles, and gray hair are useful indicators of underlying diseases. The presence of bilateral diagonal earlobe creases (DELCs), also known as Frank’s sign, correlates with a myriad of cardiovascular diseases such as coronary artery disease, cerebrovascular disease, and peripheral vascular disease. The use of Frank’s sign as a bedside predictor of underlying coronary artery disease is controversial among clinicians. We report a case of a patient with bilateral DELCs found to have significant coronary artery disease during diagnostic coronary angiography for recurrent chest pain.



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