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Case report

An Excellent Clinical Outcome with Stereotactic Radiosurgery in a Geriatric Patient with Multiple and Recurrent Brain Metastases


The incidence of brain metastases range from 10 to 20% of all adult patients with cancer and lung cancer is associated with one of the highest incidences of brain metastases. In geriatric patients, who already have limited cognitive function, whole brain radiation therapy (WBRT) can be a problem. Stereotactic radiosurgery (SRS) is a one day, outpatient treatment with minimal effect to normal brain and could particularly be useful in elderly patients. We report the case of a geriatric patient with metastatic lung adenocarcinoma who had multiple brain metastases and recurrences, who responded well to the stereotactic radiosurgery (six sessions) with acceptable tumor control.


The brain metastases incidence is actually increasing as there has been an improvement in overall patient survival due to more effective systemic therapy [1-2]. Stereotactic radiosurgery (SRS) is a primary modality of treatment in patient with brain metastases and has demonstrated efficacy in several randomized trials and multicenter studies, whether performed alone or in combination with whole-brain radiation therapy (WBRT) [3-5]. SRS has been shown to be efficacious and safe for a fewer number of brain metastasis. We report an exceptional outcome in a geriatric patient with multiple brain metastases who underwent multiple courses of SRS.

Case Presentation

An 81-year-old female with medical history significant for Raynaud's syndrome, hyperparathyroidism, and essential hypertension was found to have a subscapular subcutaneous lesion in July 2013, subsequently underwent excision and pathology was reported as a metastatic adenocarcinoma with focal neuroendocrine features in the lesion; molecular marker like epidermal growth factor receptor (EGFR) was negative for mutation and there was no anaplastic lymphoma kinase (ALK) fusion. Computed tomography (CT) chest performed in Aug 2013 revealed a 10 x 18 mm right lower lobe and a separate 10 mm right lower lobe nodule with multiple sub-5 mm nodules throughout both lungs. Positron emission tomography and computed tomography (PET-CT) confirmed fluorodeoxyglucose (FDG) avidity in the right lower lobe as well as three FDG avid pleural lesions and a destructive third lumbar vertebral (L3) lesion. Magnetic resonance imaging (MRI) of the brain (Figure 1) showed a very small lesion in left temporal region for which she underwent SRS.


She received carboplatin, pemetrexed, and bevacizumab in October 2013 for systemic disease with excellent initial response. Follow-up MRI of the brain in August 2014 and repeat in October 2014 (Figure 2) demonstrated new multiple brain metastases in left frontal and parietal region for which she underwent SRS in October 2014.


The patient was continued on maintenance pemetrexed until March 2015 and was changed to single-agent paclitaxel for systemic disease. However, paclitaxel failed to control the systemic disease and patient had progression of the systemic disease as well as new multiple brain metastases. In view of the systemic disease progression, the patient was initiated on Nivolumab in June 2015 and had stereotactic radiosurgery in August 2015. However, CT of the chest, abdomen, and pelvis with contrast in March 21, 2016 demonstrated stable disease.

In May 2016 repeat MRI (Figure 3) demonstrated new brain metastases in right parietal region, left precuneus and she again underwent SRS, although CT scans of abdomen and lung on July 2016 again showed stable disease.


MRI brain in July 2016 again revealed new right occipital lesion for which she underwent SRS on July 16. Follow-up MRI brain in September 2016 (Figure 4) revealed two new metastases in right frontal region for which the patient again had SRS.


There was no neurological deficit since the diagnosis of the brain metastases and patient tolerated the SRS treatment fairly well with good quality of the life and with no impairment in neurocognitive function.

The patient has been doing well with stable systemic disease and good performance status with Eastern Cooperative Oncology Group (ECOG) performance score of 0.

There were a total of 12 metastatic lesions identified and treated over three years. They varied in linear size from  3 mm to 12 mm. The characteristics of the brain metastases in the form of target volume, location of the brain metastases and linear size along with radiation doses have been summarized in Table 1.

Date of SRS No. of lesions Location of the lesions Target volume Maximum linear size Dose of radiation
9/26/2013 1 Lt Temporal 0.191 cc 0.8 cm 24 Gy to the 51% local isodose line
10/2/2014 4 Lt Superior frontal 0.015 cc 0.3 cm 24 Gy to the 83% local isodose line
    Lt Parietal 0.071 cc 0.4 cm 24 Gy to the 84% local isodose line
    Lt Anterior frontal 0.047 cc 0.4 cm 24 Gy to the 79% local isodose line
    Lt Mesial frontal 0.071 cc 0.6 cm 24 Gy to the 79% local isodose line
8/10/2015 3 Lt lateral frontal 0.0174 cc 0.3 cm 24 Gy to the 74% local isodose line
    Rt Parietal 0.1989 cc 0.75 cm 24 Gy to the 77% local isodose line
    Lt Occipital 0.642 cc 1.2 cm 24 Gy to the 81% local isodose line
5/27/2016 1 Rt Lateral parietal 0.275 cc 0.9 cm 24 Gy to the 62% local isodose line
7/15/2016 1 Rt Posterior Occipital 0.088 cc 0.6 cm 24 Gy to the 89% local isodose line
9/1/2016 2 Rt Superior frontal 0.05 cc 0.5 cm 24 Gy to the 53% local isodose line
    Rt Lateral frontal 0.111 cc 0.6 cm 24 Gy to the 86% local isodose line


Treatment for brain metastases is challenging and the outcome depends on various factors such as the age of the patient, performance status and the number of metastases, mass affect, tumor location and neurological deficit. Extracranial metastasis and systemic disease control have been a major determinant of the overall survival of the patient with brain metastasis.

Historically, WBRT has been the standard of care for patients with multiple brain metastases but it has also been associated with neuro-cognitive effect [6-7].

SRS has demonstrated efficacy in several randomized trials and multicenter studies, whether performed alone or in combination with WBRT. Recently, SRS has been emerged as the preferred modality of treatment for the patient with multiple brain metastases [8]. SRS has also progressively gained favor because of its minimal impact on the delivery of systemic treatment options and it may also have synergistic effect with novel immunotherapy agents.

Our patient had multiple recurrence of brain metastases since the diagnosis and underwent a total of six courses of SRS within a span of four years. Except for patient’s age (>75 years), she had fairly well controlled systemic disease, good performance status, and no neurological deficit. The patient’s multiple recurrence of the brain metastases has been well controlled with stereotactic radio-surgery with good clinical outcome. In total she received local intracranial treatment with stereotactic radiosurgery for 12 lesions with no neurological deficit. 

The rates of local control have been equivalent between SRS and WBRT but SRS alone has been found to have higher rates of recurrence after treatment as compared to WBRT because SRS only treats the lesion visible on MRI while WBRT also treats microscopic level metastatic disease [9]. Furthermore, overall survival is similar between WBRT and SRS versus SRS alone in randomized studies [9]. Recent studies in patients with brain metastasis have also demonstrated tumor volume as the prognostic factor to predict the clinical outcome [10].


Stereotactic radiosurgery is a very effective modality of treatment for recurrent and multiple brain metastases depending on the prognostic factors of the patient. Minimal cognitive decline compared with WBRT makes SRS favorable for geriatric patients with limited cognitive capacity. However, more studies are necessary on multiple SRS courses in recurrent brain metastases to determine the neuro-cognitive effect and overall outcome of the patients.


  1. Lin X, DeAngelis LM: Treatment of brain metastases. J Clin Oncol. 2015, 33:3475–3484. 10.1200/JCO.2015.60.9503
  2. Shonka N, Venur VA, Ahluwalia MS: Targeted treatment of brain metastases. Curr Neurol Neurosci Rep. 2017, 17:37. 10.1007/s11910-017-0741-2
  3. Andrews DW, Scott CB, Sperduto PW, et al.: Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial. Lancet. 2004, 363:1665–1672. 10.1016/S0140-6736(04)16250-8
  4. Sanghavi SN, Miranpuri SS, Chappell R, et al.: Radiosurgery for patients with brain metastases: a multi-institutional analysis, stratified by the RTOG recursive partitioning analysis method. Int J Radiat Oncol Biol Phys. 2001, 51:426–434. 10.1016/S0360-3016(01)01622-4
  5. Angelov L, Mohammadi AM, Barnett GH, et al.: Impact of 2-staged stereotactic radiosurgery for treatment of brain metastases ≥ 2 cm. J Neurosurg. 2017, 22:1–17. 10.3171/2017.3.JNS162532
  6. Rades D, Hornung D, Veninga T, et al.: Single brain metastasis: radiosurgery alone compared with radiosurgery plus up-front whole-brain radiotherapy. Cancer. 2012, 118:2980–2985. 10.1002/cncr.26612
  7. Brown PD, Jaeckle K, Ballman KV, et al.: Effect of radiosurgery alone vs radiosurgery with whole brain radiation therapy on cognitive function in patients with 1 to 3 brain metastases: a randomized clinical trial. JAMA. 2016, 316:401–409. 10.1001/jama.2016.9839
  8. Yamamoto M, Serizawa T, Shuto T, et al.: Stereotactic radiosurgery for patients with multiple brain metastases (JLGK0901): a multi-institutional prospective observational study. Lancet Oncol. 2014, 15:387–395. 10.1016/S1470-2045(14)70061-0
  9. Patel KR, Prabhu RS, Kandula S, et al.: Intracranial control and radiographic changes with adjuvant radiation therapy for resected brain metastases: whole brain radiotherapy versus stereotactic radiosurgery alone. J Neurooncol. 2014, 120:657–663. 10.1007/s11060-014-1601-4
  10. Bennett EE, Angelov L, Vogelbaum MA, et al.: The prognostic role of tumor volume in the outcome of patients with single brain metastasis after stereotactic radiosurgery. World Neurosurg. 2017, 104:229-238. 10.1016/j.wneu.2017.04.156
Case report

An Excellent Clinical Outcome with Stereotactic Radiosurgery in a Geriatric Patient with Multiple and Recurrent Brain Metastases

Author Information

Bicky Thapa Corresponding Author

Internal Medicine, Cleveland Clinic - Fairview Hospital, Cleveland, USA

Hamid Borghei-Razavi

Neurological Institute, Taussig Cancer Center, Cleveland Clinic

Alireza M. Mohammadi

Neurological Institute, Taussig Cancer Center, Cleveland Clinic

Manmeet Ahluwalia

Brain Tumor and Neuro-Oncology Center, Cleveland Clinic

Ethics Statement and Conflict of Interest Disclosures

Human subjects: Consent was obtained by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Case report

An Excellent Clinical Outcome with Stereotactic Radiosurgery in a Geriatric Patient with Multiple and Recurrent Brain Metastases

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