"Never doubt that a small group of thoughtful, committed citizens can change the world. Indeed, it is the only thing that ever has."

Margaret Mead
Case report
peer-reviewed

Sudden Collapse in the First Trimester: Report of Hyperacute Renal Failure Secondary to Collapsing Glomerulopathy as the Initial Presentation of Lupus



Abstract

Hyperacute renal failure is rarely the initial presentation of systemic lupus erythematosus (SLE). Pregnancy can predispose untreated lupus nephritis to acute renal failure. Collapsing glomerulopathy (CG) type of renal failure is not a new clinicopathological entity. There have been documented cases prior to 1979. It is thought that detection bias coupled with the predilection for HIV has caused this form of glomerulopathy to be incorrectly named or diagnosed as 'malignant focal segmental glomerulosclerosis (FSGS)'. This is a case of CG described in lupus nephritis. We present a case of untreated lupus in a female in whom pregnancy triggered the exacerbation of lupus nephritis that presented as collapsing glomerulopathy.



Want to read more?

Create a free account to continue reading this article.

Already a member? Login.



Case report
peer-reviewed

Sudden Collapse in the First Trimester: Report of Hyperacute Renal Failure Secondary to Collapsing Glomerulopathy as the Initial Presentation of Lupus


Author Information

Pooja Sethi

Department of Cardiology, Quillen College of Medicine, East Tennessee State University

Jennifer Treece

Internal Medicine, Quillen College of Medicine, East Tennessee State University

Chidinma Onweni Corresponding Author

Internal Medicine, Quillen College of Medicine, East Tennessee State University


Ethics Statement and Conflict of Interest Disclosures

Human subjects: Consent was obtained by all participants in this study. Conflicts of interest: The authors have declared that no conflicts of interest exist.


Share
Case report
peer-reviewed

Sudden Collapse in the First Trimester: Report of Hyperacute Renal Failure Secondary to Collapsing Glomerulopathy as the Initial Presentation of Lupus

  • Author Information
    Pooja Sethi

    Department of Cardiology, Quillen College of Medicine, East Tennessee State University

    Jennifer Treece

    Internal Medicine, Quillen College of Medicine, East Tennessee State University

    Chidinma Onweni Corresponding Author

    Internal Medicine, Quillen College of Medicine, East Tennessee State University


    Ethics Statement and Conflict of Interest Disclosures

    Human subjects: Consent was obtained by all participants in this study. Conflicts of interest: The authors have declared that no conflicts of interest exist.

    Acknowledgements


    Article Information

    Published: July 24, 2017

    DOI

    10.7759/cureus.1509

    Cite this article as:

    Sethi P, Treece J, Onweni C (July 24, 2017) Sudden Collapse in the First Trimester: Report of Hyperacute Renal Failure Secondary to Collapsing Glomerulopathy as the Initial Presentation of Lupus. Cureus 9(7): e1509. doi:10.7759/cureus.1509

    Publication history

    Received by Cureus: June 27, 2017
    Peer review began: July 05, 2017
    Peer review concluded: July 09, 2017
    Published: July 24, 2017

    Copyright

    © Copyright 2017
    Sethi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 3.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

    License

    This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Hyperacute renal failure is rarely the initial presentation of systemic lupus erythematosus (SLE). Pregnancy can predispose untreated lupus nephritis to acute renal failure. Collapsing glomerulopathy (CG) type of renal failure is not a new clinicopathological entity. There have been documented cases prior to 1979. It is thought that detection bias coupled with the predilection for HIV has caused this form of glomerulopathy to be incorrectly named or diagnosed as 'malignant focal segmental glomerulosclerosis (FSGS)'. This is a case of CG described in lupus nephritis. We present a case of untreated lupus in a female in whom pregnancy triggered the exacerbation of lupus nephritis that presented as collapsing glomerulopathy.



Want to read more?

Create a free account to continue reading this article.

Already a member? Login.



Pooja Sethi

Department of Cardiology, Quillen College of Medicine, East Tennessee State University

Jennifer Treece

Internal Medicine, Quillen College of Medicine, East Tennessee State University

Chidinma Onweni

Internal Medicine, Quillen College of Medicine, East Tennessee State University

For correspondence:
onweni@etsu.edu

Pooja Sethi

Department of Cardiology, Quillen College of Medicine, East Tennessee State University

Jennifer Treece

Internal Medicine, Quillen College of Medicine, East Tennessee State University

Chidinma Onweni

Internal Medicine, Quillen College of Medicine, East Tennessee State University

For correspondence:
onweni@etsu.edu