In this investigation, 98 clinical isolates of 10 different bacterial pathogens were tested for antibiotics susceptibility. The sources of these isolates were urine, blood, sputum and wound swaps collected from patients from Al-Rass General Hospital, Saudi Arabia. Bacterial isolates were identified and tested for susceptibility with disk diffusion method as recommended by Clinical and Laboratory Standards Institute (CLSI). The results have shown that, of the 98 bacterial isolates representing 9 different bacterial pathogens, 71(72.4 %) were Gram negatives and 27 (27.6 %) were Gram positives. 21 different antibiotic disks were used. The majority of these isolates were resistant to most antibiotics tested. Accordingly, almost all isolates were defined as multidrug resistant (MDR). Acinetobacter baumanii and Enterococcus faecalis are among the most resistant MDR which poses a serious concern. There is a need for continuous monitoring of the susceptibility of pathogens to antibiotics prescribed in hospitals.