Abstract
Background:
Rheumatoid arthritis (RA) is a chronic autoimmune disease associated with significant morbidity, disability, and healthcare burden. Increasing attention has been directed toward early identification of risk factors and preventive strategies, particularly during the preclinical phase of disease.
Objective:
To evaluate research trends, collaboration networks, and thematic focus areas in the literature on prevention and risk factors in rheumatoid arthritis.
Methods:
A bibliometric analysis was conducted using the PubMed database, including English-language human studies published between 1970 and 2026. Search terms included “rheumatoid arthritis,” “risk factors,” “prevention,” and related concepts. Publication trends, co-authorship networks, and keyword co-occurrence were analyzed using VOSviewer to identify patterns in research output and thematic clustering.
Results:
Publication output increased substantially over time, with rapid growth after 2010. Co-authorship analysis revealed highly clustered research networks, suggesting concentrated expertise with limited cross-collaboration. Keyword analysis demonstrated a strong emphasis on immune-mediated mechanisms, established risk factors, and human-focused studies. Distinct clustering between basic science and clinical research indicated a persistent translational gap. Emerging themes included the integration of genetics, biomarkers, and environmental exposures.
Conclusions:
Research on prevention and risk factors in rheumatoid arthritis has expanded significantly, with growing emphasis on early detection and precision medicine approaches. However, gaps remain in interdisciplinary collaboration and translation of findings into clinical practice. Strengthening these areas may enhance prevention strategies and improve long-term patient outcomes.
