Abstract
Background and Introduction:
To date, there has been limited characterization of treatment approaches for patients with coinfection with more than one genotype of hepatitis C virus (HCV). Additionally, there is limited research on the prevalence of these poly-genotypic infections in the United States.
Objective
In this case report, an individual with a prior history of intravenous drug use (IVDU) was found to be chronically infected with HCV genotypes 1a and 3 for nearly 20 years. There was no prior HCV treatment in the past.
Methods:
Laboratory studies before treatment revealed a high viral load (35 million viral copies), with liver fibrosis testing revealing mild stages of fibrosis (F0 and A2), elevated gamma-glutamyl transferase (GGT 71 U/L), and elevated alanine aminotransferase (ALT) 126 U/L. Treatment with sofosbuvir/velpatasvir combination therapy for 12 weeks, as recommended per HCV guidelines for single-genotype infection, was completed.
Results:
The patient achieved sustained virologic response at 12 weeks post-therapy.
Conclusion:
This case report describes the efficacy of treating coinfection with more than one HCV genotype. Still, it highlights the need for further research, not only on the prevalence of these cases in our area but also on the treatment constraints that it may carry.
