Abstract

This case underscores the rarity of intussusception in adult varicella infections. Viral infections, including VZV, are known to cause lymphoid hyperplasia and enteric nervous system dysfunction, serving as potential lead points for intussusception. This phenomenon is more commonly described in the pediatric population; however, cases in adults highlight the need for prompt recognition and intervention. Varicella primarily manifests as a self-limiting rash but can present with systemic complications, including transaminitis, pneumonia, and gastrointestinal involvement, especially in immunocompromised or adult patients. Diagnosis relies on clinical presentation and laboratory confirmation through PCR or serological testing. Management includes supportive care for gastrointestinal complications and antiviral therapy for varicella infection. Acyclovir remains the cornerstone of treatment for severe varicella, with favorable outcomes when initiated promptly. In conclusion, this case highlights the importance of maintaining a broad differential diagnosis when evaluating adult patients with abdominal pain and rash. Understanding the potential gastrointestinal and systemic complications of the varicella-zoster virus is crucial for timely diagnosis and management, particularly in atypical presentations such as intussusception.