Abstract
A disease previously associated with implantable devices and rheumatic heart disease, the last several decades have seen a rise in right-sided endocarditis secondary to IV drug use. Clinical presentation can be highly variable, prompting high suspicion for endocarditis in any patient with a history of drug use who presents with unexplained sepsis or fever of unknown origin. While most instances are effectively treated with intravenous antibiotics, more severe or refractory cases may require mechanical debulking using the AngioVAC approach
