Abstract

Cellular functions, in particular cell growth and movement, are controlled in part through the activation of the dual specificity phosphatase (DSP) called Slingshot-2 (SSH-2). SSH-2 is known to contribute to the progression of cancer and Alzheimer’s disease. Finding a specific inhibitor for SSH-2 may have a profound impact in clinical treatments for different diseases. In contrast to the traditional wet-bench method of directly determining binding affinities of different chemical compounds, we have employed a computational approach to screen for potential inhibitors for SSH-2 using grid computing technologies.