Abstract
The canonical Wnt signaling pathway has been implicated in a large majority of colon cancers. It’s prevalence in this disease makes it an ideal target for directed therapy. Using zebrafish as a screening tool, we have identified a molecule, Windorphin, that selectively blocks the Wnt pathway. This molecule was found to have significant tumor killing ability in Wnt mutated cell lines, including both prostate and colon cancer , while sparing cell lines without Wnt mutations.
