Abstract

Purpose: To analyze female liver transplant recipients reported to the National Transplantation Pregnancy Registry (NTPR) who became pregnant ≥5 years post-transplant. Methods: Data were collected via questionnaires, phone interviews and medical records. Results: There were 49 recipients with 49 pregnancies and 50 outcomes (twins). Mean age at first transplant was 18.3 ± 6.1 yrs and mean transplant-to-conception interval was 8.95 ± 3.7 yrs. There were 39 livebirths, 8 spontaneous abortions, 1 therapeutic abortion, 2 stillbirths. Comorbid conditions during pregnancy included: 22% hypertension, 8% diabetes, 19% infection, 25% preeclampsia, 6% rejection. Mean gestational age was 37.2 ± 2.5 wks and mean birthweight was 2715 ± 656 g. At last follow-up 39 children were reported healthy and developing well. At last follow-up maternal graft function was reported adequate in 39, reduced/poor in 2, 5 had died, and 3 were lost to follow-up. Conclusions: Successful pregnancy outcomes have been reported in female liver recipients with a transplant-to-conception interval ≥5 years. Long-term graft survival should be discussed during the preconception counseling.