Abstract

We present a case of gestational hypertension, eclampsia, and postpartum depression in a 39-year-old nulliparous pregnant patient following multiple prenatal severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) infections. After an initial mild first trimester case of coronavirus disease-19 (COVID-19), the patient received a 2-dose mRNA vaccine against SARS-CoV-2. Despite vaccination, she contracted two more SARS-CoV-2 infections during her third trimester of pregnancy. She subsequently developed gestational hypertension which necessitated a cesarean section at 38+4 weeks. The patient delivered a healthy neonate, however her postpartum course was complicated by eclampsia and postpartum depression. While research suggests COVID-19 in pregnancy is associated with poor maternal and fetal outcomes, the exact mechanisms remain unclear and approach to management of affected patients presents a distinct challenge to clinicians. This case bolsters current literature and emphasizes the necessity of continued research into the effects of COVID-19 in pregnant and postpartum women.