Abstract

Background: Hypersensitivity or Leukocytoclastic vasculitis following the Pfizer and Moderna Covid-19 vaccine have been reported rarely after the covid 19 vaccines in patients having underlying comorbid autoimmune conditions.

Case Presentation: A 58-year-old male came within one week after the first dose of Pfizer mRNA vaccine complaining of a rash and itching on both his hands and feet with no past medical history of any chronic disorder. He had no associated systemic symptoms. Initially, there was no response to prednisone 20mg so a comprehensive blood test was performed which showed decreased complement C3 (54 mg/dL, normal: 90-207), elevated ESR (30 mm/hr, normal: 10-20), elevated CRP 9.29 mg/L. There was no associated hemorrhage, oral mucosal lesion, or increased IgA ruling out other forms of vasculitis. On the basis of the history of the covid-19 vaccine in the previous week, he was suspected of having post-covid19 vaccine vasculitis and the steroid dose was increased. The rash began resolving after a few doses of steroids and continued for a month.

Conclusion:1. This case highlights the occurrence of vasculitis in patients with no comorbid conditions and without associated systemic symptoms.

2.Allergic or leukocytoclastic vasculitis reactions to covid vaccine components can occur weeks after the vaccine administration.