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Review article
peer-reviewed

Exploring Laser-Induced Breakdown Spectroscopy as a Potential Tool in Mohs Micrography: A Mini Review



Abstract

Mohs micrographic surgery is the technique of surgically removing skin tumors by gradually excising thin layers and visualizing under a microscope till a tumor-free zone is obtained. During the surgical procedure, visible tumors are surgically removed. During the second stage, if tumor margins are clear with the positive specimen at depth, only depth cavitations need to be done without altering the tumor diameter. Defining the depth during this procedure is a major challenge due to the nonexistence of proper guidelines. Using the laser-induced breakdown spectroscopy (LIBS) technique, depth profiling can be performed precisely, preventing excessive tissue removal and reducing time consumption during the microscopic examination.



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Review article
peer-reviewed

Exploring Laser-Induced Breakdown Spectroscopy as a Potential Tool in Mohs Micrography: A Mini Review


Author Information

Sandeep Singh

Neurology, Institute of Human Behavior and Allied Sciences (IHBAS), Delhi, India

Rupak Desai Corresponding Author

Research Coordinator, Atlanta Veterans Affairs Medical Center

Mitul Modi

PGY 1 Ap/cp, Department of Pathology, Pennsylvania Hospital of University of Pennsylvania, Philadelphia & Gujarat Cancer and Research Institute, Ahmedabad, India

Showket Hussain

Department of Molecular Oncology, National Institute of Cancer Prevention and Research


Ethics Statement and Conflict of Interest Disclosures

Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.


Review article
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Exploring Laser-Induced Breakdown Spectroscopy as a Potential Tool in Mohs Micrography: A Mini Review


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peer-reviewed

Exploring Laser-Induced Breakdown Spectroscopy as a Potential Tool in Mohs Micrography: A Mini Review

Sandeep Singh">Sandeep Singh, Rupak Desai">Rupak Desai , Mitul Modi">Mitul Modi, Showket Hussain">Showket Hussain

  • Author Information
    Sandeep Singh

    Neurology, Institute of Human Behavior and Allied Sciences (IHBAS), Delhi, India

    Rupak Desai Corresponding Author

    Research Coordinator, Atlanta Veterans Affairs Medical Center

    Mitul Modi

    PGY 1 Ap/cp, Department of Pathology, Pennsylvania Hospital of University of Pennsylvania, Philadelphia & Gujarat Cancer and Research Institute, Ahmedabad, India

    Showket Hussain

    Department of Molecular Oncology, National Institute of Cancer Prevention and Research


    Ethics Statement and Conflict of Interest Disclosures

    Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

    Acknowledgements


    Article Information

    Published: November 13, 2017

    DOI

    10.7759/cureus.1842

    Cite this article as:

    Singh S, Desai R, Modi M, et al. (November 13, 2017) Exploring Laser-Induced Breakdown Spectroscopy as a Potential Tool in Mohs Micrography: A Mini Review. Cureus 9(11): e1842. doi:10.7759/cureus.1842

    Publication history

    Received by Cureus: November 02, 2017
    Peer review began: November 07, 2017
    Peer review concluded: November 08, 2017
    Published: November 13, 2017

    Copyright

    © Copyright 2017
    Singh et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 3.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

    License

    This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Mohs micrographic surgery is the technique of surgically removing skin tumors by gradually excising thin layers and visualizing under a microscope till a tumor-free zone is obtained. During the surgical procedure, visible tumors are surgically removed. During the second stage, if tumor margins are clear with the positive specimen at depth, only depth cavitations need to be done without altering the tumor diameter. Defining the depth during this procedure is a major challenge due to the nonexistence of proper guidelines. Using the laser-induced breakdown spectroscopy (LIBS) technique, depth profiling can be performed precisely, preventing excessive tissue removal and reducing time consumption during the microscopic examination.



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Create a free account to continue reading this article.

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Sandeep Singh

Neurology, Institute of Human Behavior and Allied Sciences (IHBAS), Delhi, India

Rupak Desai

Research Coordinator, Atlanta Veterans Affairs Medical Center

For correspondence:
drrupakdesai@gmail.com

Mitul Modi

PGY 1 Ap/cp, Department of Pathology, Pennsylvania Hospital of University of Pennsylvania, Philadelphia & Gujarat Cancer and Research Institute, Ahmedabad, India

Showket Hussain

Department of Molecular Oncology, National Institute of Cancer Prevention and Research

Sandeep Singh

Neurology, Institute of Human Behavior and Allied Sciences (IHBAS), Delhi, India

Rupak Desai

Research Coordinator, Atlanta Veterans Affairs Medical Center

For correspondence:
drrupakdesai@gmail.com

Mitul Modi

PGY 1 Ap/cp, Department of Pathology, Pennsylvania Hospital of University of Pennsylvania, Philadelphia & Gujarat Cancer and Research Institute, Ahmedabad, India

Showket Hussain

Department of Molecular Oncology, National Institute of Cancer Prevention and Research