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Original article
peer-reviewed

Evaluation of Prostatic Lesions by Transrectal Ultrasound, Color Doppler, and the Histopathological Correlation



Abstract

Objective

To evaluate the role of a transrectal ultrasound (TRUS) guided biopsy and a color Doppler test in the detection of prostate cancer in patients with increased serum prostate-specific antigen (PSA) levels and/or an abnormal digital rectal examination (DRE).

Method

A total of 40 cases, ranging in age from 50 to 80 years and showing increased serum PSA levels (4-10 ng/ml) and/or abnormal DRE, were enrolled and underwent TRUS evaluation followed by color Doppler flowmetric studies. A TRUS-guided biopsy was performed in all the cases. The findings were confirmed histopathologically. Data were analyzed using the chi-square test.

Results

Histopathologically, a total of 13 cases (32.5%) were malignant. On TRUS, irregular shape, heterogeneous echotexture loss of differentiation between the peripheral and internal zones, less mean weight of the prostate, and capsular invasion were significantly associated with malignancy. On flowmetry, moderate vascularity and focal asymmetry were significantly associated with malignancy. The combined use of TRUS and color Doppler flowmetry was found to be 100% sensitive and 92.6% specific and had a positive predictive value (PPV) and a negative predictive value (NPV) of 86.7% and 100%, respectively.

Conclusion

TRUS with color Doppler flowmetry was highly sensitive and specific in the detection of prostate malignancy.



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Original article
peer-reviewed

Evaluation of Prostatic Lesions by Transrectal Ultrasound, Color Doppler, and the Histopathological Correlation


Author Information

Sachin Khanduri

Radiodiagnosis, Era's Lucknow Medical College and Hospital

Gaurav Katyal Corresponding Author

Radiodiagnosis, Era's Lucknow Medical College and Hospital

Aakshit Goyal

Radiodiagnosis, Era's Lucknow Medical College and Hospital

Saurav Bhagat

Radiodiagnosis, Era's Lucknow Medical College and Hospital

Santosh Yadav

Radiodiagnosis, Era's Lucknow Medical College and Hospital

Tarim Usmani

Radiodiagosis, Era's Lucknow Medical College and Hospital

Nikita Singh

Department of Radiology, Era's Lucknow Medical College and Hospital

Mriganki Chaudhary

Radiodiagnosis, Era's Lucknow Medical College and Hospital

Shobha Khanduri

Pathology, Era's Lucknow Medical College and Hospital


Ethics Statement and Conflict of Interest Disclosures

Human subjects: Consent was obtained by all participants in this study. Animal subjects: This study did not involve animal subjects or tissue. Conflicts of interest: The authors have declared that no conflicts of interest exist.


Original article
peer-reviewed

Evaluation of Prostatic Lesions by Transrectal Ultrasound, Color Doppler, and the Histopathological Correlation


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Original article
peer-reviewed

Evaluation of Prostatic Lesions by Transrectal Ultrasound, Color Doppler, and the Histopathological Correlation

  • Author Information
    Sachin Khanduri

    Radiodiagnosis, Era's Lucknow Medical College and Hospital

    Gaurav Katyal Corresponding Author

    Radiodiagnosis, Era's Lucknow Medical College and Hospital

    Aakshit Goyal

    Radiodiagnosis, Era's Lucknow Medical College and Hospital

    Saurav Bhagat

    Radiodiagnosis, Era's Lucknow Medical College and Hospital

    Santosh Yadav

    Radiodiagnosis, Era's Lucknow Medical College and Hospital

    Tarim Usmani

    Radiodiagosis, Era's Lucknow Medical College and Hospital

    Nikita Singh

    Department of Radiology, Era's Lucknow Medical College and Hospital

    Mriganki Chaudhary

    Radiodiagnosis, Era's Lucknow Medical College and Hospital

    Shobha Khanduri

    Pathology, Era's Lucknow Medical College and Hospital


    Ethics Statement and Conflict of Interest Disclosures

    Human subjects: Consent was obtained by all participants in this study. Animal subjects: This study did not involve animal subjects or tissue. Conflicts of interest: The authors have declared that no conflicts of interest exist.

    Acknowledgements


    Article Information

    Published: July 03, 2017

    DOI

    10.7759/cureus.1422

    Cite this article as:

    Khanduri S, Katyal G, Goyal A, et al. (July 03, 2017) Evaluation of Prostatic Lesions by Transrectal Ultrasound, Color Doppler, and the Histopathological Correlation. Cureus 9(7): e1422. doi:10.7759/cureus.1422

    Publication history

    Received by Cureus: June 08, 2017
    Peer review began: June 15, 2017
    Peer review concluded: June 29, 2017
    Published: July 03, 2017

    Copyright

    © Copyright 2017
    Khanduri et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 3.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

    License

    This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Objective

To evaluate the role of a transrectal ultrasound (TRUS) guided biopsy and a color Doppler test in the detection of prostate cancer in patients with increased serum prostate-specific antigen (PSA) levels and/or an abnormal digital rectal examination (DRE).

Method

A total of 40 cases, ranging in age from 50 to 80 years and showing increased serum PSA levels (4-10 ng/ml) and/or abnormal DRE, were enrolled and underwent TRUS evaluation followed by color Doppler flowmetric studies. A TRUS-guided biopsy was performed in all the cases. The findings were confirmed histopathologically. Data were analyzed using the chi-square test.

Results

Histopathologically, a total of 13 cases (32.5%) were malignant. On TRUS, irregular shape, heterogeneous echotexture loss of differentiation between the peripheral and internal zones, less mean weight of the prostate, and capsular invasion were significantly associated with malignancy. On flowmetry, moderate vascularity and focal asymmetry were significantly associated with malignancy. The combined use of TRUS and color Doppler flowmetry was found to be 100% sensitive and 92.6% specific and had a positive predictive value (PPV) and a negative predictive value (NPV) of 86.7% and 100%, respectively.

Conclusion

TRUS with color Doppler flowmetry was highly sensitive and specific in the detection of prostate malignancy.



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Create a free account to continue reading this article.

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Sachin Khanduri

Radiodiagnosis, Era's Lucknow Medical College and Hospital

Gaurav Katyal, M.D., Fellow Physician

Radiodiagnosis, Era's Lucknow Medical College and Hospital

For correspondence:
garvdel@gmail.com

Aakshit Goyal

Radiodiagnosis, Era's Lucknow Medical College and Hospital

Saurav Bhagat

Radiodiagnosis, Era's Lucknow Medical College and Hospital

Santosh Yadav

Radiodiagnosis, Era's Lucknow Medical College and Hospital

Tarim Usmani, M.D.

Radiodiagosis, Era's Lucknow Medical College and Hospital

Nikita Singh

Department of Radiology, Era's Lucknow Medical College and Hospital

Mriganki Chaudhary

Radiodiagnosis, Era's Lucknow Medical College and Hospital

Shobha Khanduri

Pathology, Era's Lucknow Medical College and Hospital

Sachin Khanduri

Radiodiagnosis, Era's Lucknow Medical College and Hospital

Gaurav Katyal, M.D., Fellow Physician

Radiodiagnosis, Era's Lucknow Medical College and Hospital

For correspondence:
garvdel@gmail.com

Aakshit Goyal

Radiodiagnosis, Era's Lucknow Medical College and Hospital

Saurav Bhagat

Radiodiagnosis, Era's Lucknow Medical College and Hospital

Santosh Yadav

Radiodiagnosis, Era's Lucknow Medical College and Hospital

Tarim Usmani, M.D.

Radiodiagosis, Era's Lucknow Medical College and Hospital

Nikita Singh

Department of Radiology, Era's Lucknow Medical College and Hospital

Mriganki Chaudhary

Radiodiagnosis, Era's Lucknow Medical College and Hospital

Shobha Khanduri

Pathology, Era's Lucknow Medical College and Hospital