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Case report
peer-reviewed

Dramatic Response of an Aggressive Chest Wall Recurrence to Hyperthermia, Radiation, and Chemotherapy



Abstract

Hyperthermia has been demonstrated to be an effective adjuvant oncological treatment modality in combination with chemotherapy and/or radiation. Published data have demonstrated that the addition of hyperthermia can improve local control for breast cancer chest wall recurrences. We present a patient with a very aggressive estrogen receptor-negative, progesterone receptor-negative, HER2/neu receptor-negative chest wall recurrence status-post a right modified radical mastectomy. Despite having metastatic disease, in an attempt to achieve local control and provide palliation, she was treated with hyperthermia, radiation, and chemotherapy. A near complete resolution of her chest wall recurrence in a very short time period was seen with a significant improvement in her symptoms. While she unfortunately succumbed to her disease shortly thereafter, the local control that our treatment offered her allowed her quality of life to improve significantly near the end of her life.



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Case report
peer-reviewed

Dramatic Response of an Aggressive Chest Wall Recurrence to Hyperthermia, Radiation, and Chemotherapy


Author Information

Justin Cohen Corresponding Author

Department of Radiation Oncology, University of Maryland Medical Center

Stephanie Rice

Department of Radiation Oncology, University of Maryland Medical Center

Tejan Diwanji

Department of Radiation Oncology, University of Maryland Medical Center

Steven J. Feigenberg

Department of Radiation Oncology, University of Maryland School of Medicine

Zeljko Vujaskovic

Department of Radiation Oncology, University of Maryland Medical Center


Ethics Statement and Conflict of Interest Disclosures

Human subjects: Consent was obtained by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.


Case report
peer-reviewed

Dramatic Response of an Aggressive Chest Wall Recurrence to Hyperthermia, Radiation, and Chemotherapy


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Case report
peer-reviewed

Dramatic Response of an Aggressive Chest Wall Recurrence to Hyperthermia, Radiation, and Chemotherapy

Justin Cohen">Justin Cohen , Stephanie Rice">Stephanie Rice, Tejan Diwanji">Tejan Diwanji, Steven J. Feigenberg">Steven J. Feigenberg, Zeljko Vujaskovic">Zeljko Vujaskovic

  • Author Information
    Justin Cohen Corresponding Author

    Department of Radiation Oncology, University of Maryland Medical Center

    Stephanie Rice

    Department of Radiation Oncology, University of Maryland Medical Center

    Tejan Diwanji

    Department of Radiation Oncology, University of Maryland Medical Center

    Steven J. Feigenberg

    Department of Radiation Oncology, University of Maryland School of Medicine

    Zeljko Vujaskovic

    Department of Radiation Oncology, University of Maryland Medical Center


    Ethics Statement and Conflict of Interest Disclosures

    Human subjects: Consent was obtained by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

    Acknowledgements


    Article Information

    Published: July 16, 2017

    DOI

    10.7759/cureus.1479

    Cite this article as:

    Cohen J, Rice S, Diwanji T, et al. (July 16, 2017) Dramatic Response of an Aggressive Chest Wall Recurrence to Hyperthermia, Radiation, and Chemotherapy. Cureus 9(7): e1479. doi:10.7759/cureus.1479

    Publication history

    Received by Cureus: May 24, 2017
    Peer review began: May 31, 2017
    Peer review concluded: July 11, 2017
    Published: July 16, 2017

    Copyright

    © Copyright 2017
    Cohen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 3.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

    License

    This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Hyperthermia has been demonstrated to be an effective adjuvant oncological treatment modality in combination with chemotherapy and/or radiation. Published data have demonstrated that the addition of hyperthermia can improve local control for breast cancer chest wall recurrences. We present a patient with a very aggressive estrogen receptor-negative, progesterone receptor-negative, HER2/neu receptor-negative chest wall recurrence status-post a right modified radical mastectomy. Despite having metastatic disease, in an attempt to achieve local control and provide palliation, she was treated with hyperthermia, radiation, and chemotherapy. A near complete resolution of her chest wall recurrence in a very short time period was seen with a significant improvement in her symptoms. While she unfortunately succumbed to her disease shortly thereafter, the local control that our treatment offered her allowed her quality of life to improve significantly near the end of her life.



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Justin Cohen

Department of Radiation Oncology, University of Maryland Medical Center

For correspondence:
justin.cohen@som.umaryland.edu

Stephanie Rice

Department of Radiation Oncology, University of Maryland Medical Center

Tejan Diwanji

Department of Radiation Oncology, University of Maryland Medical Center

Steven J. Feigenberg

Department of Radiation Oncology, University of Maryland School of Medicine

Zeljko Vujaskovic

Department of Radiation Oncology, University of Maryland Medical Center

Justin Cohen

Department of Radiation Oncology, University of Maryland Medical Center

For correspondence:
justin.cohen@som.umaryland.edu

Stephanie Rice

Department of Radiation Oncology, University of Maryland Medical Center

Tejan Diwanji

Department of Radiation Oncology, University of Maryland Medical Center

Steven J. Feigenberg

Department of Radiation Oncology, University of Maryland School of Medicine

Zeljko Vujaskovic

Department of Radiation Oncology, University of Maryland Medical Center